Standardized Nigella sativa seed oil ameliorates hepatic steatosis, aminotransferase and lipid levels in non-alcoholic fatty liver disease: A randomized, double-blind and placebo-controlled clinical trial

Khonche, Ahmad; Huseini, H Fallah; Gholamian, Mahdi; Mohtashami, Reza; Nabati, Farzaneh; Kianbakht, S

doi:10.1016/j.jep.2019.01.009

Cited by 55 publications

(64 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

Section: Discussionmentioning

confidence: 94%

“…In another study, intake of 2 g N. sativa powder per day during 8 weeks significantly improved triglyceride, total cholesterol, LDL and HDL in patients with Hashimoto's thyroiditis (Farhangi et al, 2018). Khonche et al (2019) showed that consumption of 2.5 mL N. sativa Seed Oil, 1.25 mL honey and 1.25 mL water as mixture after 3 months altered triglyceride, LDL) and HDL in patients with nonalcoholic fatty liver disease. Darand, Darabi, Yari, Hedayati, et al (2019) showed in patients with nonalcoholic fatty liver disease, consumption of 500 mg/day milled edible N. sativa after 12 weeks, did not alter TG, HDL‐C, total cholesterol, and LDL‐C concentrations.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta‐analysis of randomized controlled clinical trials

Hallajzadeh

Milajerdi

Mobini

et al. 2020

Phytotherapy Research

View full text Add to dashboard Cite

The aim of this systematic review and meta-analysis was to evaluate the effects of Nigella sativa (N. sativa) on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress. Two independent authors systematically examined online databases consisting of, EMBASE, Scopus, PubMed, Cochrane Library, and Web of Science from inception until October 30, 2019. Cochrane Collaboration risk of bias tool was applied to assess the methodological quality of the studied trials. The heterogeneity among the included studies were assessed using the Cochrane's Q test and I-square (I 2) statistic. Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size. A total of 50 trials were included in this meta-analysis. We found a significant reduction in

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta‐analysis of randomized controlled clinical trials

Hallajzadeh

Milajerdi

Mobini

et al. 2020

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…However, high dose of TQ could contribute to oxidative the stress-induced liver injury with LD 50 at 90.3 mg/mg [88]. A study by A. Khonche et al [49] on 120 nonalcoholic fatty liver disease (NAFLD) patients showed that the treatment with the mixture (2.5 mL sativa seed oil, 1.25 mL honey, and 1.25 mL water/ day.) for 3 months could improve liver steatosis and injury and blood levels of TG, LDL, and HDL in the NAFLD patients.…”

Section: Cardiovascular Activity and Vessel Protectionmentioning

confidence: 99%

Recent Progress on Chemical Constituents and Pharmacological Effects of the Genus Nigella

Niu

Zhou

Meng

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Seeds of the genus Nigella plants as folk medicine are often used to prevent and treat asthma, diarrhea, dyslipidemia, and other diseases around the world. Pharmacological researches showed that seed extract and seed oil have antibacterial, antioxidant, hypoglycemic, and hepatoprotective effects which attributed to their bioactive constituents such as alkaloids, saponins, flavones, and phenols. This paper has covered recent progresses on chemical and pharmacological researches on these plants, including their compounds and pharmacological effects. It was found that the chemical component researches were focused on the seed oil. Therefore, more attention should be paid to the profile of the whole constituents in the seeds.

show abstract

“…Масло чёрного тмина обладает широким спектром фармакологической активности и поэтому широко применяется в народной медицине стран Востока. Сегодня существует большое количество научных работ, посвящённых изучению фармакологической активности данного растительного сырья [6][7][8][9][10][11].…”

Section: Introductionunclassified

Results of a comparative study of <i>Nigella Sativa</i> L. Seeds oils composition

Goriainov

Хромов

Бакуреза

et al. 2020

Farm. farmakol. (Pâtigorsk)

View full text Add to dashboard Cite

This article presents results of the chemical composition study of the seeds oils lipid complex of Nigella Sativa L. grown under various geographic conditions. The task of the comprehensive study of the chemical composition of the plant and its individual parts remains relevant due to the wide spectrum of its pharmacological activity.The aim of this work is a comparative study of the fatty acid composition, a non-saponifiable fraction and the composition of essential oils of Nigella Sativa L. seeds grown in different regions of the world.Materials and methods. The combination of chromatography-mass spectrometry and 1H-NMR spectroscopy methods made it possible to study the qualitative and quantitative composition of Nigella Sativa L. lipid complex seeds. All the experiments were carried out in accordance with the requirements of the State Pharmacopoeia, 14th Ed, given in the corresponding general pharmacopeial monographs.Results. Profiles have been established and the content of fatty acids, sterines, triterpene alcohols, essential oils and thymoquinone found out in the lipid complex, has been estimated. The saponifiable portion of the complex is represented by triglycerides (81.7–95.3%), di(3.9–15.2%) and monoglycerides (0.7–4.1%). They mainly contain linoleic (55.8–60.6%), oleic (21.8–24.6%), palmitic (10.0–12.8%), stearic (2.4–3.2 %) and cis-11.14-eicosadiene (2.3–2.6%) acids. In the lipid complex, the contents of sterines and triterpene alcohols were 0.4–0.7%; up to 70% of the fraction was represented by β-sitosterol (22.5–29.2%), cycloartenol (20.1–36.6%) and 24 methylenecycloartanol (9.5–19.9%). In the trace amounts (up to 1.0%), cholesterol has been detected in all the samples. In the lipid complexes, the content of thymoquinone ranged from 0.7 to 2.6%.Conclusion. A comparative study of the seeds lipid complex of Nigella Sativa L. grown under various geographic conditions, has been carried out. The marker compounds as well as their content standards for determining the authenticity of raw materials (thymoquinone, para-cimen, cis-11.14-eicosadienic acid), have been identified.

show abstract

Standardized Nigella sativa seed oil ameliorates hepatic steatosis, aminotransferase and lipid levels in non-alcoholic fatty liver disease: A randomized, double-blind and placebo-controlled clinical trial

Cited by 55 publications

References 25 publications

Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta‐analysis of randomized controlled clinical trials

Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta‐analysis of randomized controlled clinical trials

Recent Progress on Chemical Constituents and Pharmacological Effects of the Genus Nigella

Results of a comparative study of <i>Nigella Sativa</i> L. Seeds oils composition

Contact Info

Product

Resources

About