Standardized qualitative evaluation of scar tissue properties in an animal wound healing model

Hollander, Dirk A.; Erli, H. J.; Theisen, A.; Falk, Stephan; Kreck, Thomas; Müller, Stefan

doi:10.1046/j.1524-475x.2003.11212.x

Cited by 32 publications

(26 citation statements)

References 16 publications

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“…In the present study, we also found that a 230 mT static magnetic treatment of the wound increased the wound breaking strength compared with sham magnet group. It implied that SMF could help to improve the quality of wound healing; similar results had also been reported in previous studies [7, 15]. …”

Section: Discussionsupporting

confidence: 87%

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Therapeutic Effects of Static Magnetic Field on Wound Healing in Diabetic Rats

Zhao

Deng

et al. 2017

Journal of Diabetes Research

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Objective. To investigate the effects of static magnetic field (SMF) on cutaneous wound healing of Streptozotocin- (STZ-) induced diabetic rats. Methods. 20 STZ-induced diabetic rats were randomly divided into two groups (10 in each group): diabetic rats with SMF exposure group which were exposed to SMF by gluing one magnetic disk of 230 mT intensity and diabetic rats with sham SMF exposure group (sham group). 10 normal Wistar rats were used as the control group. One open circular wound with 2 cm diameter in the dorsum was generated on both normal and diabetic rats and then covered with sterile gauzes. Wound healing was evaluated by wound area reduction rate, mean time to wound closure, and wound tensile strength. Results. The wound area reduction rate in diabetic rats in comparison with the control group was significantly decreased (P < 0.01). Compared with sham magnet group, diabetic rats under 230 mT SMF exposure demonstrated significantly accelerated wound area reduction rate on postoperative days 7, 14, and 21 and decreased gross time to wound closure (P < 0.05), as well as dramatically higher wound tissue strength (P < 0.05) on 21st day. Conclusion. 230 mT SMF promoted the healing of skin wound in diabetic rats and may provide a non-invasive therapeutic tool for impaired wound healing of diabetic patients.

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Section: Discussionsupporting

confidence: 87%

“…This parameter of the skin also exhibits a progressive increase in continual tissue repair during the wound healing process [15]. In the present study, we also found that a 230 mT static magnetic treatment of the wound increased the wound breaking strength compared with sham magnet group.…”

Section: Discussionsupporting

confidence: 80%

Therapeutic Effects of Static Magnetic Field on Wound Healing in Diabetic Rats

Zhao

Deng

et al. 2017

Journal of Diabetes Research

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“…These properties are similar to the differences in human beings between skin sites with a high density of arterioles and venules and sites with predominantly nutritive capillary perfusion. Although pig skin is more physiologically similar to the human skin (Hollander et al 2003), the high cost and our inexperience with porcine husbandry make it prohibitive to use a porcine model. Previous studies in rat models produced valuable results (Herrman et al 1999, Li et al 2006, Kwan et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Local cooling reduces skin ischemia under surface pressure in rats: an assessment by wavelet analysis of laser Doppler blood flow oscillations

Jan¹,

Lee²,

Liao³

et al. 2012

Physiol. Meas.

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The objectives of this study were to investigate the effects of local cooling on skin blood flow response to prolonged surface pressure and to identify associated physiological controls mediating these responses using wavelet analysis of blood flow oscillations in rats. Twelve Sprague Dawley rats were randomly assigned into three protocols, including pressure with local cooling (Δt= −10°C), pressure with local heating (Δt= 10°C), and pressure without temperature changes. Pressure of 700 mmHg was applied to the right trochanter area of rats for 3 hours. Skin blood flow was measured using laser Doppler flowmetry. The 3-hour loading period was divided into non-overlapping 30 min epochs for analysis of the changes of skin blood flow oscillations using wavelet spectral analysis. The wavelet amplitudes and powers of three frequencies (metabolic, neurogenic and myogenic) of skin blood flow oscillations were calculated. The results showed that after an initial loading period of 30 min, skin blood flow continually decreased in the conditions of pressure with heating and of pressure without temperature changes, but maintained stable in the condition of pressure with cooling. Wavelet analysis revealed that stable skin blood flow under pressure with cooling was attributed to changes in the metabolic and myogenic frequencies. This study demonstrates that local cooling may be useful for reducing ischemia of weight-bearing soft tissues that prevents pressure ulcers.

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“…Facial morphological changes, such as sagging, are also thought to be associated with an increase of body fat percentage (2). in its response to external stress and in its internal organization (4). The increase in the weight burden as a result of accumulated fat and increased numbers of adipose cells is speculated to weaken the supporting function of the dermis.…”

Section: Introductionmentioning

confidence: 99%

Increased subcutaneous adipose tissue impairs dermal function in diet‐induced obese mice

Ezure

Amano

2009

Experimental Dermatology

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Increment of subcutaneous adipose tissue is a risk factor for facial morphological changes, such as sagging, which may be at least partly because of the increased weight burden of accumulated fat. However, it is not clear how the increase of subcutaneous adipose tissue affects dermal structure and function. We examined this issue in HR-1 hairless mice given a high-fat diet (HFD). After having been fed with HFD for 12 weeks, the mice became obese and the subcutaneous adipose tissue layer was significantly thickened, while the dermal layer became significantly thinner than that of control mice fed normal diet. However, the thickness of the dermal layer was not changed in the ear pinna, which lacks a subcutaneous adipose layer, suggesting that increase of subcutaneous adipose tissue may induce dermal changes. The number of dermal fibroblasts in the dermis was significantly reduced in obese mice, although there was no change in gene expression levels of extracellular matrix components, including collagen, hyaluronic acid synthase, fibulin5, fibrillin-1, laminin β1, matrix metalloproteinases and tissue inhibitor of metalloproteinases. Dermal elasticity was significantly decreased in obese hairless mice. These results suggest that subcutaneous adipose cells in obese mice may reduce the proliferation of dermal fibroblasts and induce a decrease of dermal thickness and elasticity. Therefore, the increment of the subcutaneous adipose layer in obese subjects may induce impairment of dermal biomechanical characteristics and promote the appearance of sagging.

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Standardized qualitative evaluation of scar tissue properties in an animal wound healing model

Cited by 32 publications

References 16 publications

Therapeutic Effects of Static Magnetic Field on Wound Healing in Diabetic Rats

Therapeutic Effects of Static Magnetic Field on Wound Healing in Diabetic Rats

Local cooling reduces skin ischemia under surface pressure in rats: an assessment by wavelet analysis of laser Doppler blood flow oscillations

Increased subcutaneous adipose tissue impairs dermal function in diet‐induced obese mice

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