Standardized uptake value and apparent diffusion coefficient of endometrial cancer evaluated with integrated whole‐body PET/MR: Correlation with pathological prognostic factors

Simultaneous positron emission tomography and MRI (PET/MRI) is a technology that combines the anatomic and quantitative strengths of MR imaging with physiologic information obtained from PET. PET and computed tomography (PET/ CT) performed in a single scanning session is an established technology already in widespread and accepted use worldwide. Given the higher cost and complexity of operating and interpreting the studies obtained on a PET/MRI system, there has been question as to which patients would benefit most from imaging with PET/MRI versus PET/CT. In this article, we compare PET/MRI with PET/CT, detail the applications for which PET/MRI has shown promise and discuss impediments to future adoption. It is our hope that future work will prove the benefit of PET/MRI to specific groups of patients, initially those in which PET/CT and MRI are already performed, leveraging simultaneity and allowing for greater degrees of multiparametric evaluation.

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“…). Similar results have been shown regarding other tumors of gynecologic origin, such as ovarian cancer and endometrial carcinoma …”

Section: Current Applications Of Pet/mrimentioning

confidence: 99%

PET/MRI: Where might it replace PET/CT?

Ehman

Johnson

Villanueva-Meyer

et al. 2017

Magnetic Resonance Imaging

210

137

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“…Although there was a significant and inverse correlation with ADC min and SUV max (r=-0.677, p<0.001), the SUV max of the primary tumor was associated with disease-free and overall survival rates while ADC min was not. The other study of interest relating to this issue in the literature was reported by Shih et al (28). Although the authors used the data obtained from an integrated PET/MRI system, they similarly found a significant inverse correlation between the SUV max and ADC min of the primary tumor in 36 patients with EC (r=-0.53, p=0.001).…”

Section: Discussionmentioning

confidence: 98%

Correlation of Minimum Apparent Diffusion Coefficient and Maximum Standardized Uptake Value of the Primary Tumor with Clinicopathologic Characteristics in Endometrial Cancer

Budak¹,

Toptaş²,

Aydın

et al. 2017

Mirt

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Objective:To explore the correlation of the primary tumor’s maximum standardized uptake value (SUVmax) and minimum apparent diffusion coefficient (ADCmin) with clinicopathologic features, and to determine their predictive power in endometrial cancer (EC).Methods:A total of 45 patients who had undergone staging surgery after a preoperative evaluation with 18F-fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) and diffusion-weighted magnetic resonance imaging (DW-MRI) were included in a prospective case-series study with planned data collection. Multiple linear regression analysis was used to determine the correlations between the study variables.Results:The mean ADCmin and SUVmax values were determined as 0.72±0.22 and 16.54±8.73, respectively. A univariate analysis identified age, myometrial invasion (MI) and lymphovascular space involvement (LVSI) as the potential factors associated with ADCmin while it identified age, stage, tumor size, MI, LVSI and number of metastatic lymph nodes as the potential variables correlated to SUVmax. In multivariate analysis, on the other hand, MI was the only significant variable that correlated with ADCmin (p=0.007) and SUVmax (p=0.024). Deep MI was best predicted by an ADCmin cutoff value of ≤0.77 [93.7% sensitivity, 48.2% specificity, and 93.0% negative predictive value (NPV)] and SUVmax cutoff value of >20.5 (62.5% sensitivity, 86.2% specificity, and 81.0% NPV); however, the two diagnostic tests were not significantly different (p=0.266).Conclusion:Among clinicopathologic features, only MI was independently correlated with SUVmax and ADCmin. However, the routine use of 18F-FDG PET/CT or DW-MRI cannot be recommended at the moment due to less than ideal predictive performances of both parameters.

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“…Hybrid PET/MRI enable to measure glucose metabolism and cellular density in tumor by simultaneous FDG, PET, and DWI acquisition. In malignant lesions, inverse correlation was found between SUV and ADC value [91,92]. Volumetric measurement of tumor is highly correlated when comparing the results from PET images and MRI images (both of T2 weighted images and DWI) [93].…”

Section: Complementary Role Of Pet/mr Imagingmentioning

confidence: 98%

FDG Whole-Body PET/MRI in Oncology: a Systematic Review

Kwon

Becker

Goo

et al. 2016

Nucl Med Mol Imaging

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The recent advance in hybrid imaging techniques enables offering simultaneous positron emission tomography (PET)/magnetic resonance imaging (MRI) in various clinical fields. 18F-fluorodeoxyglucose (FDG) PET has been widely used for diagnosis and evaluation of oncologic patients. The growing evidence from research and clinical experiences demonstrated that PET/MRI with FDG can provide comparable or superior diagnostic performance more than conventional radiological imaging such as computed tomography (CT), MRI or PET/CT in various cancers. Combined analysis using structural information and functional/molecular information of tumors can draw additional diagnostic information based on PET/MRI. Further studies including determination of the diagnostic efficacy, optimizing the examination protocol, and analysis of the hybrid imaging results is necessary for extending the FDG PET/MRI application in clinical oncology.

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Standardized uptake value and apparent diffusion coefficient of endometrial cancer evaluated with integrated whole‐body PET/MR: Correlation with pathological prognostic factors

Abstract: SUVmax and ADCmin of endometrial cancer derived from integrated PET/MR are inversely correlated and are associated with pathological prognostic factors.

Cited by 52 publications

References 32 publications

PET/MRI: Where might it replace PET/CT?

PET/MRI: Where might it replace PET/CT?

Correlation of Minimum Apparent Diffusion Coefficient and Maximum Standardized Uptake Value of the Primary Tumor with Clinicopathologic Characteristics in Endometrial Cancer

FDG Whole-Body PET/MRI in Oncology: a Systematic Review

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