Background: Musculoskeletal abnormalities are estimated to be 21.1% of all birth defects, if left untreated such defects represent high morbidity in patients. Advances in biomedical technologies such as prosthetics and 3D printing can further improve treatment in orthopedics and enhance patient’s quality of life. The aim of this paper is to review the literature in search of the state of the art in 3D printing related to orthopedics and musculoskeletal birth defects.Methods: A comprehensive literature search was performed in indexed databases. Keywords included: orthopedics,”, “3d printing”, “congenital”, “malformations”, “defects” and “treatment”. A total of 29 articles were suitable for the subject matter and included for this review.Results and Discussion: 3D printing allows a better surgical planning in the orthopedic field as it can be used as a surgical guide or for creating custom 3D-printed tools, devices, patient-specific prostheses, and implants. Also, complex limb malformations can be modeled, and further 3D printed to accurately understand, study, and plan a surgical approach. Scaffold and bio-ink for 3D bioprinters can also be capable of developing bone and cartilage suitable for complex orthopedic and pediatric remodeling. Conclusion: 3D printing in orthopedics and musculoskeletal birth defects is an important and innovative subject, as it allows to make better surgical approaches and supply the structural function of the original malformed tissue.