Standardizing the use of whole slide images in digital pathology

Daniel, Christel; Rojo, Marcial García; Klossa, Jacques; Mea, Vincenzo Della; Booker, David L.; Beckwith, Bruce A.; Schräder, Thomas

doi:10.1016/j.compmedimag.2010.12.004

Cited by 48 publications

(32 citation statements)

References 20 publications

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“…The main research was conducted in the following. IHE Anatomic Pathology has proposed an Anatomic Pathology Structured Report (APSR), based in HL7 Clinical Document Architecture (CDA) [1,2]. In this document, anatomic pathology observations (e.g., breast-specimen collection procedure) and the possible values (e.g., breast excision without wire-guided localization) have been coded using the PathLex coding system.…”

Section: Informatics Standards In Pathologymentioning

confidence: 99%

Standardization Efforts of Digital Pathology in Europe

Rojo

Daniel

Schräder

2012

Analytical Cellular Pathology

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Abstract.Background: EURO-TELEPATH is a European COST Action IC0604. It started in 2007 and will end in November 2011. Its main objectives are evaluating and validating the common technological framework and communication standards required to access, transmit, and manage digital medical records by pathologists and other medical specialties in a networked environment.Business modelling: Working Group 1, "Business Modelling in Pathology," has designed main pathology processes -Frozen Study, Formalin Fixed Specimen Study, Telepathology, Cytology, and Autopsy -using Business Process Modelling Notation (BPMN).Informatics standards in pathology: Working Group 2 has been dedicated to promoting the application of informatics standards in pathology, collaborating with Integrating Healthcare Enterprise (IHE), Digital Imaging and Communications in Medicine (DICOM), Health Level Seven (HL7), and other standardization bodies.Conclusions: Health terminology standardization research has become a topic of great interest. Future research work should focus on standardizing automatic image analysis and tissue microarrays imaging. Digital pathologyThe concept of digital pathology includes the use of multiple digital images (gross studies, microscopic, and, molecular pathology images), including whole slide microscopic digital images that are integrated with pathology information systems, enterprise image repositories, and electronic health records. The main challenges in digital pathology include educational, technological, and complexity of health information systems. 2210-7177/12/$27.50

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Section: Informatics Standards In Pathologymentioning

confidence: 99%

Standardization Efforts of Digital Pathology in Europe

Rojo

Daniel

Schräder

2012

Analytical Cellular Pathology

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“…26 Wider adoption of WSI in pathology practice is anticipated to occur following further technical advancements, better workflow, integration of these systems with the laboratory information system, promotion of reimbursement for technical services, lowered costs, standardization for use in clinical practice, clarification of regulations, and pathologist acclimatization. 2,9,27 Also impacting the clinical use of WSI, the US Food and Drug Administration has indicated that it considers WSI systems class III (highest risk) medical devices and has advised that they should be regulated as such. [28][29][30] Validation, in the context of new technology or instrumentation, refers to a process that aims to demonstrate that the new method performs as expected for its intended use and environment prior to its application for patient care.…”

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confidence: 99%

“…2013;137:1710-1722; doi: 10.5858/arpa.2013-0093-CP) I n the last decade, digital imaging in pathology has been significantly impacted by the development and application of whole slide imaging (WSI) technology. [1][2][3][4][5][6][7] The automated WSI scanner is a robotic microscope capable of digitizing an entire glass slide, using software to merge or stitch individually captured images into a composite digital image. The critical components of an automated WSI device (system) include the hardware (scanner composed of an optical microscope and digital camera connected to a computer), software (responsible for image creation and management, viewing of images, and image analysis where applicable), and network connectivity.…”

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confidence: 99%

Validating Whole Slide Imaging for Diagnostic Purposes in Pathology: Guideline from the College of American Pathologists Pathology and Laboratory Quality Center

Pantanowitz

Sinard

Henricks

et al. 2013

Archives of Pathology & Laboratory Medicine

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Context.-There is increasing interest in using whole slide imaging (WSI) for diagnostic purposes (primary and/ or consultation). An important consideration is whether WSI can safely replace conventional light microscopy as the method by which pathologists review histologic sections, cytology slides, and/or hematology slides to render diagnoses. Validation of WSI is crucial to ensure that diagnostic performance based on digitized slides is at least equivalent to that of glass slides and light microscopy. Currently, there are no standard guidelines regarding validation of WSI for diagnostic use.Objective.-To recommend validation requirements for WSI systems to be used for diagnostic purposes.Design.-The College of American Pathologists Pathology and Laboratory Quality Center convened a nonvendor panel from North America with expertise in digital pathology to develop these validation recommendations. A literature review was performed in which 767 international publications that met search term requirements were identified. Studies outside the scope of this effort and those related solely to technical elements, education, and image analysis were excluded. A total of 27 publications were graded and underwent data extraction for evidence evaluation. Recommendations were derived from the strength of evidence determined from 23 of these published studies, open comment feedback, and expert panel consensus.Results.-Twelve guideline statements were established to help pathology laboratories validate their own WSI systems intended for clinical use. Validation of the entire WSI system, involving pathologists trained to use the system, should be performed in a manner that emulates the laboratory's actual clinical environment. It is recommended that such a validation study include at least 60 routine cases per application, comparing intraobserver diagnostic concordance between digitized and glass slides viewed at least 2 weeks apart. It is important that the validation process confirm that all material present on a glass slide to be scanned is included in the digital image.Conclusions.-Validation should demonstrate that the WSI system under review produces acceptable digital slides for diagnostic interpretation. The intention of validating WSI systems is to permit the clinical use of this technology in a manner that does not compromise patient care.

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“…Ce format permet notamment d'établir des liens entre les comptes rendus et les images, qu'il s'agisse d'images illustratives de petite taille ou de LV [22,25,26].…”

Section: Référencesunclassified