2012
DOI: 10.1002/dta.1367
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Standardless 1H NMR determination of pharmacologically active substances in dietary supplements and medicines that have been illegally traded over the Internet

Abstract: Dietary supplements and medicines are widely marketed over the Internet. Such products may be counterfeited and lack some or all of the labelled ingredients, or, in the case of lifestyle supplements, illegally contain pharmacologically active substances, such as anorectic or androgenic compounds. The market control - especially in the case of customs seizures - is complex, as reference substances necessary for identification and calibration in traditional high performance liquid chromatography (HPLC) or gas ch… Show more

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Cited by 34 publications
(47 citation statements)
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“…NMR spectra of aqueous solutions were acquired using an optimized water suppression 1D noesygppr1d pulse sequence [2], where delay D7 (delay for inversion recovery) can be varied to achieve full relaxation of the targeted protons. During preliminary experiments, D7 was optimized via successive prolongation of the D7 time from 10 to 60 s until the integrated signal area remains constant and this optimum value was chosen for further experiments.…”
Section: Nmr Methodsmentioning
confidence: 99%
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“…NMR spectra of aqueous solutions were acquired using an optimized water suppression 1D noesygppr1d pulse sequence [2], where delay D7 (delay for inversion recovery) can be varied to achieve full relaxation of the targeted protons. During preliminary experiments, D7 was optimized via successive prolongation of the D7 time from 10 to 60 s until the integrated signal area remains constant and this optimum value was chosen for further experiments.…”
Section: Nmr Methodsmentioning
confidence: 99%
“…For quantification with an internal standard, the well-known equation was used, which includes molar weight, integral, number of protons of reference compound and analyte as well as purity and concentration of the reference [2,7,23]:…”
Section: Qnmr Based On Internal Standardmentioning
confidence: 99%
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“…We wondered if "walk-in" 1 H NMR analysis combined with contemporary spectral-analysis software might allow even inexperienced investigators to verify the composition of grey-market research chemicals with a reasonable degree of confidence. The attraction of 1 H NMR over MS is threefold: (1) the cost is significantly lower; less than 25 percent, (2) it provides sufficient information to potentially identify an unknown in the absence of a reference spectrum, [25] and (3) aryl regioisomers are more readily differentiated.…”
Section: Introductionmentioning
confidence: 99%
“…Spectral imaging technology in accordance with di®erent spectroscopy can be divided into UVvisible spectral imaging,°uorescence spectral imaging, near infrared spectral imaging, mid-infrared spectral imaging, Raman spectral imaging and NMR imaging. 13,14 Traditional infrared spectroscopy obtained the average spectrum of a single point or small area, which is the average composition of the sample or the characteristics, ideally suited for the analysis of homogeneous material. Macro-infrared spectral imaging technology is complementary to traditional IR techniques, which can achieve the spatial and concentration distribution of di®erent components in the nonuniformly mixed sample.…”
Section: Introductionmentioning
confidence: 99%