In this paper, a personalist ethical perspective on end-of-life care of severely ill newborns is presented, by posing two questions. (1) Is it ethically justified to decide not to start or to withdraw life-sustaining treatment in severely ill newborns? And (2), is it ethically justified, in exceptional cases, to actively terminate the life of severely ill newborns?Based on five valuesrespect for life and for the dignity of the human person, quality of life, respect for the process of dying, relational autonomy, and justicean ethical assessment is conducted that brings us to an answer to the two ethical questions. (1) Noninitiation or withdrawal of life-sustaining medical treatment in severely ill newborns is ethically acceptable, and might even be a moral duty, when initiation or continuing of medical treatment can be considered as futile or even harmful. (2) However, according to the personalist approach, it is not ethically acceptable to actively terminate the life of a severely ill newborn.