Standards of Practice in Transarterial Radioembolization

Mahnken, Andreas H.; Spreafico, Carlo; Maleux, Geert; Helmberger, Thomas; Jakobs, Tobias

doi:10.1007/s00270-013-0600-8

Cited by 43 publications

(19 citation statements)

References 55 publications

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“…35,36 Planning-angiography was done to evaluate vascular liver anatomy. After injection of Technetium-99m-macroaggregated-albumin (Tc99m-MAA) into the target arteries, SPECT/CT was performed to exclude extrahepatic Tc99m-MAA deposition, to quantify pulmonary shunting, and to evaluate tumor-to-nontumor uptake-ratio.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of a Simplified Intravoxel Incoherent Motion (IVIM) Analysis of Diffusion-Weighted Imaging for Prediction of Tumor Size Changes and Imaging Response in Breast Cancer Liver Metastases Undergoing Radioembolization

et al. 2016

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Section: Methodsmentioning

confidence: 99%

Evaluation of a Simplified Intravoxel Incoherent Motion (IVIM) Analysis of Diffusion-Weighted Imaging for Prediction of Tumor Size Changes and Imaging Response in Breast Cancer Liver Metastases Undergoing Radioembolization

et al. 2016

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“…Regarding the detailed technical approach, we refer to the just previously published standards of practice in transarterial radioembolization [18]. In our patient cohort, 1.0-2.5 GBq were applied in a single administration of microspheres.…”

Section: Methodsmentioning

confidence: 99%

Radioembolization with Yttrium-90 Microspheres (SIRT) in Pancreatic Cancer Patients with Liver Metastases: Efficacy, Safety and Prognostic Factors

Michl¹,

Haug²,

Jakobs

et al. 2013

Oncology

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Objective: To analyze the clinical efficacy of ⁹⁰Y radioembolization in liver metastases from pancreatic cancer, to describe treatment toxicities and to identify biomarkers as predictors of outcome. Methods: Data from 19 pancreatic cancer patients (9 females/10 males) who had received ⁹⁰Y radioembolization for metastatic liver disease between 06/2004 and 01/2011 were analyzed retrospectively. Results: The median age at ⁹⁰Y radioembolization was 63 years (range 43-77). In 16 patients, previous palliative gemcitabine-based chemotherapy was given for metastatic disease. Objective response in the liver after ⁹⁰Y radioembolization was 47%. Median local progression-free survival in the liver was 3.4 months (range 0.9-45.0). Median overall survival (OS) was 9.0 months (range 0.9-53.0) and 1-year survival was 24%. Cox regression models for baseline biomarkers at ⁹⁰Y radioembolization revealed correlations of increased carbohydrate antigen 19-9 (p = 0.02) and C-reactive protein (p = 0.03) with shorter OS. Short-term adverse events (nausea, vomiting, fatigue, fever and abdominal pain) did not exceed grade 3. As long-term adverse events, liver abscesses, gastroduodenal ulceration, cholestasis and cholangitis, ascites and spleen infarction were observed. Conclusion:⁹⁰Y radioembolization is able to induce an encouraging local response rate of liver metastases of pancreatic cancer patients. Most short-term toxicities are manageable; however, patients should be followed up carefully for severe long-term toxicities.

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“…Diese für die 90 Y-RE speziellen Komplikationen sind die Fehlembolisation und somit Fehlbestrahlung von Nichtzielorganen und die "radioembolisation-induced liver disease" (REILD; [35]). …”

Section: Komplikationenunclassified

Radioembolisation mit Yttrium-90-Mikrosphären

Teichgräber

Gebauer

2017

Onkologe

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Standards of Practice in Transarterial Radioembolization

Cited by 43 publications

References 55 publications

Evaluation of a Simplified Intravoxel Incoherent Motion (IVIM) Analysis of Diffusion-Weighted Imaging for Prediction of Tumor Size Changes and Imaging Response in Breast Cancer Liver Metastases Undergoing Radioembolization

Evaluation of a Simplified Intravoxel Incoherent Motion (IVIM) Analysis of Diffusion-Weighted Imaging for Prediction of Tumor Size Changes and Imaging Response in Breast Cancer Liver Metastases Undergoing Radioembolization

Radioembolization with Yttrium-90 Microspheres (SIRT) in Pancreatic Cancer Patients with Liver Metastases: Efficacy, Safety and Prognostic Factors

Radioembolisation mit Yttrium-90-Mikrosphären

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