The article outlines a methodological concept of political sensibility, building upon the political difference theory. Merging the ideas of the associative and dissociative theoretical branches of political difference literature, first, an integrated framework of the political condition is presented. From this, analytical dimensions are derived, namely, the associative/dissociative, the political/apolitical/discontentious, the static/processual, and the vertical/horizontal dimensions of the political. Second, the interpretive and ontological turns in social science are conceptualized, according to this framework, as a politicization of science. Taking this motion further, third, ideas to enact a politically sensible science are developed along the methodologically turned dimensions (merging the second and the third to an acknowledging/acting dimension). A political sensibility could deliver analytical categories to look upon political phenomena beyond structurally limited conceptions of “politics.” Methodologically, it could ease designing situated social science research, that is, research that consciously conceives of itself as part of the social realities it studies.