Staphylocoagulase *

Tager, Morris; Drummond, Margaret C.

doi:10.1111/j.1749-6632.1965.tb11632.x

Cited by 30 publications

(6 citation statements)

References 56 publications

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“…These globular domains are connected by long triple-helical structures. Coa·prothrombin complexes, which convert human fibrinogen to the self-polymerizing fibrin, are not targeted by circulating thrombin inhibitors [19], allowing coagulase to bypass the physiological regulatory steps of blood coagulation pathways [21].…”

Section: Introductionmentioning

confidence: 99%

Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity

et al. 2010

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The bacterial pathogen Staphylococcus aureus seeds abscesses in host tissues to replicate at the center of these lesions, protected from host immune cells via a pseudocapsule. Using histochemical staining, we identified prothrombin and fibrin within abscesses and pseudocapsules. S. aureus secretes two clotting factors, coagulase (Coa) and von Willebrand factor binding protein (vWbp). We report here that Coa and vWbp together are required for the formation of abscesses. Coa and vWbp promote the non-proteolytic activation of prothrombin and cleavage of fibrinogen, reactions that are inhibited with specific antibody against each of these molecules. Coa and vWbp specific antibodies confer protection against abscess formation and S. aureus lethal bacteremia, suggesting that coagulases function as protective antigens for a staphylococcal vaccine.

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Section: Introductionmentioning

confidence: 99%

Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity

et al. 2010

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“…Presumptive MRSA were further screened for coagulase and thermonuclease production. A part of colony was emulsified in normal saline then mixed with rabbit plasma; clumping indicated positive result [ 17 ]. Colonies grown on BHI agar were further incubated for 2 h at 60°C and overlaid with thermonuclease agar and further incubated at 37°C till the development of pink zone around the positive control [ 18 ].…”

Section: Methodsmentioning

confidence: 99%

Prevalence of Methicillin Resistant Staphylococcal Bioaerosols in and around Residential Houses in an Urban Area in Central India

Kumar

Goel

2016

Journal of Pathogens

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Methicillin resistant staphylococci (MRS) commonly found in clinical samples or associated environment pose a major health challenge globally. The carriage rate of MRS in human population is high, especially in India but research on airborne distribution of MRS is scanty. The present study aimed to evaluate the prevalence of MRS in indoor and outdoor environment of residential houses. Air samples were collected using impactor air sampler. The total counts of viable bacteria, staphylococci, and MRS along with the particles of various sizes were determined from indoor and outdoor environment of 14 residential houses. MRS bacteria were identified as methicillin resistant S. aureus (MRSA) or coagulase negative staphylococci (CNS) employing biochemical and PCR assays. The average concentration of MRS inside and outside of the houses was 5.9% and 4.6% of the total bacteria, respectively. The maximum correlation of total indoor and outdoor bacteria with particulate matter was 10 μm (r = 0.74) and 5 μm (r = 0.84), respectively. Statistically, significant positive correlation of staphylococci and MRS was found with particles of 10–25 μm inside the houses. Molecular surveillance, antibiotic stewardship programme, and infection control policies can help to manage increasing MRS burden in developing countries.

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“…SC nonproteolytically activates the blood coagulation zymogen, prothrombin (ProT) through interactions localized to the N-terminal 324 residues, and the SC-(1-325)⅐(pro)thrombin catalytic complex recognizes and cleaves fibrinogen (Fbg) as a specific substrate (2)(3)(4). The C-terminal region of SC contains five to eight 27-residue repeat sequences that mediate distinctly different Fbg binding interactions (5).…”

Section: Staphylocoagulase (Sc)mentioning

confidence: 99%

Novel Fluorescent Prothrombin Analogs as Probes of Staphylocoagulase-Prothrombin Interactions

Panizzi

Friedrich

Fuentes‐Prior

et al. 2006

Journal of Biological Chemistry

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Staphylocoagulase *

Cited by 30 publications

References 56 publications

Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity

Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity

Prevalence of Methicillin Resistant Staphylococcal Bioaerosols in and around Residential Houses in an Urban Area in Central India

Novel Fluorescent Prothrombin Analogs as Probes of Staphylocoagulase-Prothrombin Interactions

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