Staphylococcal Endophthalmitis Following Cataract Extraction in a Patient with Darierʼs Disease

Bacteriological aspects of Darier’s disease

“…These findings shed new light on the clinical assessment and treatment of severe exacerbations of DD. One immediate benefit is increased attention to the pre‐operative preparation of DD patients to prevent a post‐operative surgery site infection as previously reported in these patients 11,12 . Additional research is needed to further define the nature, magnitude and significance of S. aureus lesional skin and nares colonization in DD.…”

“…DD locus has been mapped to chromosome 12q23‐24.1, and mutations in the ATP2A2 gene have been shown to be responsible for DD 3 . Several studies have found a significant prevalence of cutaneous infections, either bacterial or viral 2,4–12 . In a detailed clinical study on DD, 37 of 141 patients (26%) recalled bacterial skin infections that had been treated with oral antibiotics 2 .…”

“…Cutaneous bacterial infections reported in DD were usually localized and well controlled, 2 although there were reports of widespread and life‐threatening bacterial infections including sepsis, 8–10 some with a fatal outcome 9,10 . In addition, endophthalmitis after cataract surgery was reported 11,12 . Infections are one of the stress factors noted in DD exacerbations 2,13 …”

Buphthalmos development in adult: case report

“…In addition, the patient presen ted a 3 mm epithelial defect in his left eye (OS) and subcapsular cata ract OU. The average intraocular pressure (IOP) was 46 mmHg in the right eye (5) and 30 mmHg in OS, with advanced disc cup in both eyes despite maximum topical antiglaucoma therapy. A trabeculectomy was performed in OD, with severe wound healing problems during the followup ( Figure 1A).…”

In Vivo Confocal Microscopy of the Cornea in Darier-White Disease

“…1 Ocular involvement in Darier-White disease has been observed, with eyelid and corneal abnormalities being reported. [2][3][4][5] To date, however, examination of corneal abnormalities in Darier-White disease has been limited to slitlamp observation [2][3][4][5] and microscopic examination of superficial peripheral biopsy samples in cases with confirmed corneal abnormalities. 2,3 In this article we use in vivo confocal microscopy to describe the general corneal morphological features present in 5 members (4 affected and 1 unaffected) of a 5-generation, 32member, Swedish family with Darier-White disease, 15 of whom are affected.…”