A simple bed-making routine results in considerable dissemination from both wool and cotton fabrics. Spread to other beds appears to occur both by direct contact and by the aerial route. The number of viable organisms recovered from the infected bedding fell by 90% after the first 72 hours. The significance of these results and those of other workers in relation to the problem of hospital crossinfection is discussed. We are indebted to Dr R. L. Willing, medical superintendent, Northfield Infectious Diseases Hospital, and to members of the nursing staff, whose interest and cooperation made this experiment possible. Our thanks are also due to Dr. Bermard Nicholson, medical superintendent, Royal Adelaide Hospital, for supplies of hospital bedding.