Staphylococcal Infection Resistant to Chloramphenicol, Erythromycin, and Novobiocin

Abstract

To the Nuffield Foundation we are particularly indebted; they, by financial ,ssistancc, not only ensured the development of the apparatus but also ils clinical success by their support to the project as a whole.

Treatment of Staphylococcemia

“…This finding has also been reported by F in l a n d (29,30). The lack o f resistance when the erythromycin novobiocin regimen was used was in keeping with the results o f B a r b e r et al (26).…”

“…Results in children also appear to have been better, perhaps because o f the age or the nature o f the underlying health o f the patient (23). In several studies, however, the problem o f erythromycin resistance was underscored and confirmed our experience that resistant strains implanted readily and in addition, resistance could develop in a given phage type o f organism while the drug was being given (24)(25)(26). Data on the use o f chloramphenicol as the sole agent in staphylococcal disease are not extensive (27) but A bboud and W a is b r e n 's data, as well as those from the Mayo Clinic (14) were similar to ours.…”

“…Data on the use o f chloramphenicol as the sole agent in staphylococcal disease are not extensive (27) but A bboud and W a is b r e n 's data, as well as those from the Mayo Clinic (14) were similar to ours. In spite o f the evidence F ish e r has collected (28), concerning the relative lack o f resistance to chloramphenicol.it was a problem for us and has been for others even when the drug was used in combination (26,29,30).…”

“…In spite o f these potential drawbacks, there have been other favo rable reports on the use o f the chloramphenicol and erythromycin (3,26) and the latter with novobiocin (26) as a combination therapy. However, as has been repeatedly emphasized, it was not possible to make a direct comparison o f these results with the more toxic regi mens o f vancomycin, ristocetin or kanamycin or some other combina tion therapies.…”

Antibiotic Resistance in <i>Pseudomonas aeruginosa</i> from Infections of the Ear, Nose and Throat

“…Degrees of cross-resistance between chloramphenicol and the chemically-unrelated chlortetracycline have been described in respect of Staphylococcus pyogenes and E. coli by P ansy et al [1950], while Barber et al [1958] have reported a moderate increase in resistance to chloramphenicol in staphylococci made resistant to the unrelated erythromycin. From tables III and IV it is possible to demonstrate a strongly unilateral cross-resistance involving chloramphenicol and oxytetracycline.…”