Staphylococcal scalded skin syndrome in a neonate

Kadam, Sachin; Tagare, Amit; Deodhar, Jayant; Tawade, Yashwant; Pandit, Anand

doi:10.1007/s12098-009-0212-0

Cited by 12 publications

(9 citation statements)

References 6 publications

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“…A particular strain of Staphylococcus aureus is the cause, leading to blistering of the upper layer of the skin and releasing of a circulating exotoxin . In neonates, SSSS most likely is associated with poor immunity to staphylococcal toxins and renal immaturity, resulting in poor clearance of toxins . The incidence of SSSS is reported to be 0.09 to 0.13 cases per million people in Germany and 251.1 cases per million children younger than 1 year old in the Czech Republic .…”

mentioning

confidence: 99%

Staphylococcal Scalded Skin Syndrome in Neonates: An 8‐Year Retrospective Study in a Single Institution

Hua

Wei

et al. 2013

Pediatric Dermatology

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Staphylococcal scalded skin syndrome (SSSS) is a rare disorder in children. Complications may occur without timely treatment. Mortality in children with SSSS is approximately 4%. Other than a limited number of case reports, data on SSSS in neonates are limited. The objective of the current study was to investigate SSSS in neonates. A retrospective review of neonates with a diagnosis of SSSS from January 2004 to January 2012 was performed. Population distribution, historical features, physical examination findings including laboratory tests, antibiotic therapies, and outcomes were evaluated. Thirty-nine cases were included, 31 (79.5%) in the last 4 years. The mean patient age was 17.4 ± 7.7 days. Boys (25 cases) were more commonly affected, and occurrence during summer and autumn months was more frequent. The face was the most common body part affected and the area most commonly initially affected. Fever, high white blood cell count, and high C-reactive protein levels were uncommon. Pneumonia was the most frequent complication (74.4%). The positive rate of Staphylococcus aureus isolation was low (23.5%). Drug susceptibility tests showed that amoxicillin with clavulanic acid and cephalosporins were effective in practice. The median length of hospitalization was 9.0 days. All of the 39 neonates were cured without scarring. This study established basic epidemiologic characteristics of a group of neonates diagnosed with SSSS. In the presence of a clinical suspicion of SSSS, even with apparently normal laboratory tests, immediate treatment with cephalosporins, β-lactamase-resistant semisynthetic penicillin, or both is advocated.

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mentioning

confidence: 99%

Staphylococcal Scalded Skin Syndrome in Neonates: An 8‐Year Retrospective Study in a Single Institution

Hua

Wei

et al. 2013

Pediatric Dermatology

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“…Certain risk factors for SSSS are well established, such as insufficient infection control practices in nursing homes and hospitals, impaired renal clearance, 9 and poor immunity to staphylococcal toxins. 10 While most SSSS is attributed to methicillin-sensitive S. aureus, an increase in methicillin-resistant bacteria has also been observed. 11,12 One study found higher rates of SSSS in rural vs. urban areas, suggesting there may be sociodemographic and/or environmental risk factors for SSSS.…”

Section: What Does This Study Add?mentioning

confidence: 99%

Epidemiology of staphylococcal scalded skin syndrome in U.S. children

Staiman¹,

Hsu²,

Silverberg

2018

Br J Dermatol

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Summary Background Staphylococcal scalded skin syndrome (SSSS) is a blistering dermatosis caused by exfoliative toxins released from Staphylococcus aureus. Objectives To describe the incidence, costs, length of stay (LOS), comorbidities and mortality of SSSS in U.S. children. Methods The Nationwide Inpatient Sample 2008–2012 was analysed, including a 20% sample of U.S. hospitalizations and 589 cases of SSSS. Results The mean annual incidence of SSSS was 7·67 (range 1·83–11·88) per million U.S. children, with 45·1 cases per million U.S. infants age < 2 years. In multivariable logistic regression models, SSSS was significantly associated with the following (shown as adjusted odds ratio and 95% confidence interval): female sex (1·12, 1·00–1·25), age (2–5 years: 13·31, 11·82–14·99; 6–10 years: 2·93, 2·35–3·66; 11–17 years: 0·44, 0·31–0·63); race/ethnicity (black: 0·69, 0·58–0·84) and season (winter: 2·04, 1·66–2·50; summer: 3·47, 2·86–4·22; autumn: 3·04, 2·49–3·70), with increasing odds over time (2010–2011: 2·28, 2·07–2·51; 2012: 2·98, 2·69–3·30). The geometric mean (95% confidence interval) LOS and cost of hospitalization for patients with vs. without SSSS were 3·2 (3·0–3·4) vs. 2·4 (2·4–2·5) days and $4624·0 ($4250–$5030) vs. $1872 ($1782·7–$1965). Crude inpatient mortality rates (with 95% confidence intervals) were similar for children with vs. without SSSS (0·33%, 0·00–0·79% vs. 0·36%, 0·34–0·39%). SSSS was associated with other infections, including in the upper respiratory tract and skin. Conclusions The prevalence of SSSS appears to be increasing over time, and was associated with a number of sociodemographic factors and other infections. Further studies are needed to confirm these findings and reduce rising rates of SSSS.

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“…Differential diagnosis of SSSS may include sunburn, drug reaction, toxic epidermal necrolysis, Kawasaki disease, extensive bullous impetigo, viral exanthema, toxic shock syndrome and pemphigus foliaceus amongst others. SSSS usually follows a benign course when diagnosed and treated appropriately . Otherwise, severe infections such as sepsis, cellulitis and pneumonia may develop .…”

Section: Answermentioning

confidence: 99%

Neonate with peeling of skin and blistering

2019

J Paediatrics Child Health

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Staphylococcal scalded skin syndrome in a neonate

Cited by 12 publications

References 6 publications

Staphylococcal Scalded Skin Syndrome in Neonates: An 8‐Year Retrospective Study in a Single Institution

Staphylococcal Scalded Skin Syndrome in Neonates: An 8‐Year Retrospective Study in a Single Institution

Epidemiology of staphylococcal scalded skin syndrome in U.S. children

Neonate with peeling of skin and blistering

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