Staphylococcal scalded skin syndrome mimicking toxic epidermal necrolysis in a healthy adult

Abstract

Introduction: Staphylococcal scaled skin syndrome (SSSS) presents generalized form bullous impetigo caused by Staphylococcus aureus (S. aureus) infection, typically seen in infants and children. SSSS may occur also in adults; however, the majority of adult cases are those with immunosuppression. Atypical clinical features of impetigo in adults sometimes make it difficult to diagnose correctly. Case Report: A 74-year-old healthy woman was hospitalized, complaining of extensive desquamative erythema and a number of erosions. She was administered oral antiviral drugs under suspicion of herpes zoster prior to 10 days. Initial diagnosis on the admission was toxic epidermal necrolysis (TEN) due to antiviral tablets; however, steroid pulse therapy resulted in no effect. Bacterial culture yielded coagulasepositive methicillin-resistent S. aureus, producing exfoliative toxin B. A biopsy specimen showed subcorneal splitting of the epidermis. The diffuse erosions gradually improved over 10 days by the treatment with intravenous antibiotics. Conclusions:The differentiation between streptococcal scaled skin syndrome (SSSS) and TEN is sometimes difficult. It is important to remind SSSS when we suspect TEN, even in healthy adults.

TEN mimics: Classification and practical approach to toxic epidermal necrolysis-like dermatoses

“…Once a diagnosis of SSSS is established, anti-staphylococcal antibiotic therapy should be given immediately. 11 Toxic shock syndrome (TSS) Toxic shock syndrome (TSS) presents with a high fever of more than 38.9C, hypotension, the involvement of at least three organ systems as well as diffuse erythroderma and desquamation. 12 Menstrual TSS accounts for most reported cases, but non-menstrual TSS cases have increased.…”