Staphylococcidal Capability of Rabbit Peritoneal Macrophages in Relation to Infection and Elicitation: Delayed-Type Hypersensitivity Without Increased Resistance

Lenhart, Nancy A.; Mudd, Stuart

doi:10.1128/iai.5.5.757-762.1972

Cited by 12 publications

(6 citation statements)

References 23 publications

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“…Humoral immunity may contribute to the protection as bacteriolytic or opsonizing antibody (4). Recently, delayed hypersensitivity has been reported to occur in animals (5)(6)(7)(8)(9) and in human beings (10) infected with staphylococci. Bactericidal activity of macrophages may be enhanced in the presence of delayed hypersensitivity.…”

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confidence: 99%

Immunological Aspects of Staphylococcal Skin Infection

Tsuda

1977

The Journal of Dermatology

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Patients with staphylococcal infection of the skin were examined for immunological status. All cases examined in the present study had gamma-globulin levels within the normal range. The proliferative response of peripheral blood lymphocytes to staphylococcal antigen was significantly depressed in patients with furunculosis as compared with that in patients with common furuncle or in healthy controls. All patients with furunculosis showed higher titers of anti-Staphylococcus aureus antibody than did those with furuncle. The dissociation between cellular and humoral immunity in furunculosis seems to be explained in terms of immune deviation.

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confidence: 99%

Immunological Aspects of Staphylococcal Skin Infection

Tsuda

1977

The Journal of Dermatology

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“…MATERIALS AND METHODS Organism. S. aureus strain 18Z was used throughout as test organism and for infection of rabbits and was prepared and used as described in the previous report (7).…”

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“…Phage-lysed staphylococci. Staphylococcal phage lysate (SPL; Staphage lysate, Delmont Laboratories, Inc., Swarthmore, Pa.) was used for skin testing and for treatment of rabbits after infection with S. aureus (7).…”

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“…Testing of staphylococcidal capability. The modified Maaloe and tissue culture-chamber methods were used as described (7). RESULTS…”

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“…Analysis of the scatter plots provides other evidence. The macrophage populations found after infection and elicitation must have been evoked by a whole series of interactions and transformations (7).…”

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Staphylococcidal Capability of Rabbit Peritoneal Macrophages in Relation to Infection and Elicitation: Induction and Elicitation of Activated Macrophages

Lenhart

Mudd

1972

Infect Immun

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The capability of macrophages to inactivate ingested staphylococci can be augmented when repeated infection is followed by specific elicitation with staphylococcal lysate. The increase in staphylococcidal capability with specific elicitation after infection is not dramatic but is statistically significant. The percentage of change in staphylococcidal capability after infection and specific elicitation is systematically related to the staphylococcidal capability of the populations of macrophages in the same rabbits studied prior to infection. When the capability of the initial populations of macrophages has been high, the percentage of change after infection and elicitation may be slight or even negative. When the staphylococcidal capability of the initial population of macrophages in a given rabbit has been low, there is typically a significant increase in this capability after infection and elicitation. It is shown at the cellular level that it is possible to evoke a population of activated macrophages, by a procedure which is analogous to procedures reported as useful in human practice.

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