Staphylococcus aureus bacteremia in patients with SARS-CoV-2 infection

Falces‐Romero, Iker; Bloise, Iván; Cendejas-Bueno, Emilio; Montero-Vega, María Dolores; Romero, María Pilar; García‐Bujalance, Silvia; Toro-Rueda, Carlos; Ruiz‐Carrascoso, Guillermo; Quiles-Melero, Inmaculada; Lázaro-Perona, Fernando; Mingorance, Jesús; Gutiérrez-Arroyo, Almudena; Ruiz-Bastián, Mario; Ligero-López, Jorge; Grandioso-Vas, David; Guedez-López, Gladys Virginia; García-Clemente, Paloma; Hernández, María Gracia Liras; García-Sánchez, Consuelo; Sánchez-Castellano, Miguel; José-Villar, Sol San; Maldonado-Barrueco, Alfredo; Roces-Álvarez, Patricia; García-Navarro, Paula; García-Rodríguez, Julio; Rodríguez-Ayala, Montserrat; Almazán-Gárate, Esther Ruth; Sanz-González, Claudia

doi:10.1016/j.medcli.2023.01.012

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…Higher rates of Staphylococcus aureus and its mortality in COVID-19 patients were also previously reported. Nosocomial transmission may be due to known risk factors, such as intubation and central venous catheters [ 8 , 9 , 49 , 50 ]. Interestingly, although the frequency of Klebsiella pneumoniae bacteremia was notable, its occurrence did not increase along with the CS dose.…”

Section: Discussionmentioning

confidence: 99%

Corticosteroid Dosing Level, Incidence and Profile of Bacterial Blood Stream Infections in Hospitalized COVID-19 Patients

Papic,

Bistrovic,

Cikara

et al. 2024

Viruses

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COVID-19 patients with severe or critical symptoms are often treated with corticosteroids, per contemporary guidelines. Due to their immunosuppressive and immunomodulatory properties, corticosteroids are associated with the development of superinfections. We aimed to retrospectively assess patterns of corticosteroid use and the profiles of bacterial blood stream infections associated with exposure to different dosing levels, in a cohort of 1558 real-life adult COVID-19 patients. A total of 1391 (89.3%) patients were treated with corticosteroids, with 710 (45.6%) patients receiving low, 539 (34.6%) high and 142 (9.1%) very high corticosteroid doses. Bacteremia developed in a total of 178 (11.4%) patients. The risk of bacteremia was of similar magnitude between the no and low-dose corticosteroid treatments (p = 0.352), whereas it progressively increased with high (OR 6.18, 95% CI (2.66–14.38), p < 0.001) and very high corticosteroid doses (OR 8.12, 95% CI (3.29–20.05), p < 0.001), compared to no corticosteroid treatment. These associations persisted after multivariate adjustments and were present independently of sex, comorbidity burden, and mechanical ventilation. The profiles of individual bacterial pathogens differed depending on the used corticosteroid doses. High and very high corticosteroid doses are frequently used for real-life COVID-19 patients with severe and critical clinical presentations and are associated with a higher risk of bacteremia independently of sex, comorbidity burden, and mechanical ventilation use.

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Section: Discussionmentioning

confidence: 99%

Corticosteroid Dosing Level, Incidence and Profile of Bacterial Blood Stream Infections in Hospitalized COVID-19 Patients

Papic,

Bistrovic,

Cikara

et al. 2024

Viruses

View full text Add to dashboard Cite

show abstract

“…In general, the diseases caused by this bacterium can be classified as superficial, invasive, or toxic, or even present mixed characteristics of toxic and invasive [8,9]. Additionally, a retrospective study reported high rates of S. aureus bacteremia incidence in COVID-19 patients and higher methicillin resistance and 15-day mortality rates than in non-COVID-19 patients [11].…”

Section: Introductionmentioning

confidence: 99%

Manual Friction with Ethyl Alcohol at 70% (w/v) to Disinfect Three-Way Stopcocks

Souza

Monteiro

Bim

et al. 2023

Hygiene

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The disinfection procedures aim to reduce the microbial load, but there are doubts about the risks of contamination spreading into the lumens of devices, such as three-way stopcocks (3-WS). This study aimed at an in vitro evaluation of the antibacterial procedure of manual friction of 3-WS intentionally contaminated and to determine the solution dispersion into the lumens. Laboratory experiments were developed in two steps: evaluation of bacterial spread through intentional contamination with Staphylococcus aureus and Pseudomonas aeruginosa, and alcohol dispersion into the 3-WS lumens. After manual friction of the 3-WS with saline solution at 0.85% (w/v) [control group], S. aureus and P. aeruginosa were isolated in the lumens of 55.6% and 27.8% of the devices, respectively. However, after the disinfection of the 3-WS with ethyl alcohol at 70% (w/v), there was no bacterial contamination in the lumens of the 3-WS. On the other hand, the solution dispersion (dye) into the lumens was evidenced by two different techniques: Durham tubes (5.6%) and swabs (46.3%). The manual friction of the 3-WS with ethyl alcohol at 70% demonstrated antibacterial efficacy, but it refers to reflections on the risk of solution diffusion into the venous network and the inherent clinical practice situations and patient safety.

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Genomic analysis of Staphylococcus aureus isolates from bacteremia reveals genetic features associated with the COVID-19 pandemic

Sánchez-Osuna,

Pedrosa,

Bierge

et al. 2024

iScience

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Staphylococcus aureus bacteremia in patients with SARS-CoV-2 infection

Cited by 5 publications

References 10 publications

Corticosteroid Dosing Level, Incidence and Profile of Bacterial Blood Stream Infections in Hospitalized COVID-19 Patients

Corticosteroid Dosing Level, Incidence and Profile of Bacterial Blood Stream Infections in Hospitalized COVID-19 Patients

Manual Friction with Ethyl Alcohol at 70% (w/v) to Disinfect Three-Way Stopcocks

Genomic analysis of Staphylococcus aureus isolates from bacteremia reveals genetic features associated with the COVID-19 pandemic

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