Staphylococcus Aureus Malignant External Otitis

Abstract

Malignant external otitis is a severe infection of the external auditoy canal, characterized by high gravity and mortality. It can arrive to skull base and originate intracranial complications. The most frequent pathogenic agent is Pseudomonas aeruginosa. Authors described two cases of external malignant otitis caused by Staphylococcus aureus, explaining clinical features, progression, diagnostic and therapeutic approach, prognosis of this disease. A comparison between Pseudomonas aeruginosa and Staphylococcus aureus malignant otitis was described, associated with a literature analysis.

CRISPR/Cas9 Genome Editing for Tissue‐Specific In Vivo Targeting: Nanomaterials and Translational Perspective

“…[ 12 ] Nonetheless, this technique has some drawbacks, including that plasmid delivery into the nucleus is typically difficult, and the large size of Cas9, in contrast to the complete plasmid, makes delivery problematic. [ 13 ] The most commonly used vector for the delivery of plasmids is adeno‐associated virus (AAV), which has limited payload capacity along with several limitations associated with toxicity. Additionally, the plasmid must be first transcribed into Cas9 mRNA, followed by translation to Cas9 protein inside the cells, which is a time‐consuming process.…”