Staphylococcus lugdunensis, a serious pathogen in periprosthetic joint infections: comparison to Staphylococcus aureus and Staphylococcus epidermidis

Lourtet-Hascoët, Julie; Bicart‐See, A.; Félicé, M P; Giordano, G.; Bonnet, É.

doi:10.1016/j.ijid.2016.08.007

Cited by 45 publications

(38 citation statements)

References 25 publications

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“…Although retrospective data have to be carefully interpreted, they intrigue clinicians, because the results reported in the literature suggest that the mortality rate of S. aureus endocarditis is approximately 20%, whereas the global mortality rate of CoNS endocarditis is approximately 12% (18,19). The occurrence of bone and joint infections appeared recently in retrospective studies describing prosthetic joint infections, particularly knee joint infections (20). Argemi et al 3and Douiri et al (21) showed in two recently published studies that 40% of all clinical samples that tested positive for S. lugdunensis were obtained from patients with proven infections, particularly bone and joint infections.…”

Section: S Lugdunensis Virulence: Growing Evidences From Clinical Stmentioning

confidence: 99%

Is Staphylococcus lugdunensis Significant in Clinical Samples?

et al. 2017

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The implication of coagulase-negative staphylococci in human diseases is a major issue, particularly in hospital settings wherein these species often act as opportunistic pathogens. In addition, some coagulase-negative staphylococci such as have emerged as pathogenic bacteria, implicated in severe infections, particularly, osteoarticular infections, foreign-body-associated infections, bacteremia, and endocarditis. studies have shown the presence of several putative virulence factors such as adhesion factors, biofilm production, and proteolytic factors that might explain clinical manifestations. Taken together, the clinical and microbiological data might change the way clinicians and microbiologists look at in clinical samples.

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Section: S Lugdunensis Virulence: Growing Evidences From Clinical Stmentioning

confidence: 99%

Is Staphylococcus lugdunensis Significant in Clinical Samples?

et al. 2017

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“…Among the S lugdunensis PJI episodes (summarized in Table 1), we could identify the site of infection in 84, among which 58 (69%), 24 (28.6%), and 2 (2.4%) episodes were in knees, hips, and other sites, respectively. This observation was previously made by the authors of the largest 2 series of S lugdunensis PJI [2], [29]. Presentation of PJI due to S lugdunensis can vary widely between acute symptoms such as fever and local site inflammation to unexplained dull aching pain at the site of surgery.…”

Section: Discussionmentioning

confidence: 62%

“…Presentation of PJI due to S lugdunensis can vary widely between acute symptoms such as fever and local site inflammation to unexplained dull aching pain at the site of surgery. Delay between time of surgery and presentation can be as short as 3 weeks [29] or as long as 10 years [24].…”

Section: Discussionmentioning

confidence: 99%

“…[28]96 TKR, 3 THRLourtet-Hascoet et al. [29]28(58-78)13 M, 15 F4 CVD, 2 cancer, 1 DM, 1 rheumatoid disease3-56 wk16 TKR, 10 THR, 1 foot, 1 shoulderArgemi et al. [30]170F2 yTKR

CVD, cardiovascular disease; DM, diabetes mellitus; F, female; HBV, hepatitis B; M, male; MG, myasthenia gravis; No., number of patients; THR, total hip replacement; TKR, total knee replacement.

…”

Section: Discussionmentioning

confidence: 99%

“…However, comparison of the success rate of different strategies was not possible because of the lack of universal definition of a successful treatment and the scarcity of information regarding the success of treatment of each strategy. In the absence of clear recommendations for optimal surgical management of S lugdunensis PJI and bearing in mind its similar virulence, it should be treated as S aureus rather than CoNS [29].…”

Section: Discussionmentioning

confidence: 99%

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Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection

2018

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Prosthetic joint infection is usually caused by staphylococci. Among the coagulase-negative staphylococci, Staphylococcus lugdunensis is important because it behaves as a pathogen similar to S aureus. It also develops biofilms, and the biofilm phenotype can appear as small-colony variants. Although genetically indistinguishable, they differ in size and antibiotic susceptibility from the parent strain and are responsible for chronic persistent infection and failure of antibiotic treatment. They can also lead to misinterpretation of results. The patient reported here underwent total knee replacement and 2 years later presented with prosthetic joint infection. Tissue samples and prosthesis taken at revision grew S lugdunensis, the majority of which were small-colony variants. Recommendations are made for their detection and identification.

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Staphylococcus lugdunensis in children: A retrospective analysis

Bowman

Deshpande

Balfour

et al. 2022

Pediatric Investigation

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Importance: Staphylococcus lugdunensis (S. lugdunensis) is a coagulasenegative staphylococcus (CoNS), found commonly as skin flora in humans. While most species of CoNS are clinically benign, S. lugdunensis can exhibit a similar virulence to that of S. aureus. However, there is scant data concerning S. lugdunensis infection in the pediatric population. Objective: To ascertain local S. lugdunensis infection rates and sensitivity patterns in the pediatric population. Methods: A retrospective analysis was undertaken of all S. lugdunensis isolates across a 6-year period from 2015 to 2020. Data were collected from electronic patient notes and laboratory records. Matrix-assisted laser desorption ionization and time of flight mass spectrometry were used to identify isolates. Results: Ninety-six isolates of S. lugdunensis were identified from 86 patients. Of these, 34 isolates were treated as an infection. Twenty-three (67.6%) were found to have skin as the primary source of infection. While the observed number was small, central nervous system (CNS) sources of S. lugdunensis infection appear to be a significant source: all three isolates cultured from cerebrospinal fluid were clinically managed as infection. All three were associated with ventriculoperitoneal (VP) shunt infection. No cases of S. lugdunensis infective endocarditis were identified. About 18.6% of S. lugdunensis isolates were resistant to flucloxacillin. Interpretation: S. lugdunensis is an uncommon but significant cause of infection in the pediatric population and appears to be a rising cause of CNS infection, particularly when associated with VP shunts. Flucloxacillin is recommended locally as the first choice of antibiotic.

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Staphylococcus lugdunensis, a serious pathogen in periprosthetic joint infections: comparison to Staphylococcus aureus and Staphylococcus epidermidis

Abstract: S. lugdunensis is an emerging pathogen with a pathogenicity quite similar to that of S. aureus. This coagulase-negative Staphylococcus must be identified precisely in PJI, in order to select the appropriate surgical treatment and antibiotics .

Cited by 45 publications

References 25 publications

Is Staphylococcus lugdunensis Significant in Clinical Samples?

Is Staphylococcus lugdunensis Significant in Clinical Samples?

Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection

Staphylococcus lugdunensis in children: A retrospective analysis

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