Staphylococcus lugdunensis Skin Infection: Report of 16 Cases

García‐Malinis, Ana Julia; Milagro, Ana; Sopena, Luis Torres; Gilaberte, Yolanda

doi:10.1016/j.adengl.2021.01.004

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…lugdunensis shares more than 70% of its genome with S. aureus [2]. S. lugdunensis has been represented as a "wolf in sheep's clothing" as it causes many serious diseases, such as skin and soft tissue infections (SSTI), subcutaneous tissue infections, bone and joint infections, prosthetic joint infections (PJI), vascular catheter-related infections, infective endocarditis (IE), bacteremia and abscesses [3][4][5][6][7][8][9][10]. Although S. lugdunensis is susceptible to most antibiotics [11][12][13][14] and lacks many of the virulence factors that S. aureus possesses, such as protein A, enterotoxins A, B or C, toxic shock syndrome toxin (TSST), hemagglutinin and toxin [1,15], this wolf in disguise appears to be equipped with other virulence factors and is capable of expressing pathological mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Searching for Virulence Factors among Staphylococcus lugdunensis Isolates from Orthopedic Infections: Correlation of β-hemolysin, hemolysin III, and slush Genes with Hemolytic Activity and Synergistic Hemolytic Activity

Ravaioli,

Campoccia,

Mirzaei

et al. 2023

IJMS

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Staphylococcus lugdunensis is an emerging high-virulent pathogen. Here, the presence and expression of virulence genes (icaA, fbl, vwbl, fbpA, slush A, B and C, and genes of the putative β-hemolysin and hemolysin III) and the ability to induce synergistic hemolytic activity and hemolysis after 24, 48 and 72 h were investigated in a collection of twenty-two S. lugdunensis clinical isolates. The collection of isolates, mainly from implant orthopedic infections, had previously been grouped by ribotyping/dendrogram analysis and studied for biofilm matrices, biomasses and antibiotic resistances. Two isolates, constituting a unique small ribogroup sharing the same cluster, exhibited an amplicon size of the slush operon (S. lugdunensis synergistic hemolysin) which was shorter than the expected 977 bp. This outcome can predict the genetic lineage of the S. lugdunensis strains. One isolate (cra1342) presented two deletions: one of 90 bp in slush A and the other of 91 bp in slush B. Another isolate (N860314) showed a single 193 bp deletion, which encompassed part of the slush B terminal sequence and most of slush C. The isolate N860314 was devoid of hemolytic activity after 24 h, and the first consideration was that the deleted region deals with the coding of the active enzymatic site of the slush hemolysin. On the other hand, cra1342 and N860314 isolates with different slush deletions and with hemolytic activity after 24 and 48 h, respectively, could have replaced the hemolytic phenotype through other processes.

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Section: Introductionmentioning

confidence: 99%

Searching for Virulence Factors among Staphylococcus lugdunensis Isolates from Orthopedic Infections: Correlation of β-hemolysin, hemolysin III, and slush Genes with Hemolytic Activity and Synergistic Hemolytic Activity

Ravaioli,

Campoccia,

Mirzaei

et al. 2023

IJMS

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“…However, S. pseudointermedius nevertheless is a common cause of skin and soft tissue infections in dogs, cats and humans [5,6,21]. In recent years, CoNS species, such as S. epidermidis [22][23][24], S. haemolyticus [25] and S. lugdunensis [26], have also been associated with opportunistic infections in humans [12,23,[27][28][29]. The recognition of some CoNS as pathogens in veterinary medicine has emerged with S. epidermidis and some subspecies of S. schleiferi causing skin and ear infections in dogs [30][31][32][33], as well as S. felis related to lower urinary tract disease, eye infections and otitis in cats [34,35].…”

Section: Introductionmentioning

confidence: 99%

Isolation and Identification of Staphylococcus Species Obtained from Healthy Companion Animals and Humans

Thomson

García

Miles

et al. 2022

Veterinary Sciences

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The close contact between people and their pets has generated the exchange of skin microbiota, accompanied by bacteria that present resistance to antibiotics. Staphylococcus spp., opportunistic pathogens present in the skin and mucosa of mammals, have had their importance recognized in human and veterinary medicine. The objectives of this study were to identify Staphylococcus spp. present in isolates from the nostrils of healthy humans, dogs and cats as well as to determine their phenotype of resistance to methicillin. Strain identification was performed by MALDI-TOF mass spectrometry and antimicrobial susceptibility was determined using a disk diffusion assay for 12 antibiotics. Sixty humans (veterinary and technicians), sixty dogs and sixty cats were sampled; of them, 61.6%, 56.6% and 46.6%, respectively, carried Staphylococcus spp. in their nostrils, and only two people carried two different species of Staphylococcus in the only anatomical site sampled. A methicillin-resistant phenotype was present in 48.7% of the humans, 26.5% of the dogs and 57.1% of the cats, and sampled. These results demonstrate the presence of Staphylococcus spp. strains resistant to methicillin in personnel who work in contact with animals, as well as in dogs and cats that entered the same hospital or veterinary clinic, which alerts us to the potential transfer of these strains to or between people, dogs and/or cats.

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“…Although most CoNS species are often considered common skin commensals causing less severe infections or as contaminants, S lugdunensis can cause a severe disease reminiscent of virulent infections frequently attributable to S aureus. 11 Indeed, multiple recent reports have implicated that S lugdunensis can cause a variety of infections, such as skin and soft tissue infection, 12 , 13 infective endocarditis (IE), 14 , 15 bone and prosthetic joint infections, 16 endophthalmitis, 17 and systemic infections. 18 , 19 Furthermore, S lugdunensis is added as a typical causative organism to the recently revised 2023 Duke-International Society for Cardiovascular Infectious Diseases (ISCVID) IE Criteria, given its virulence and high risk of IE in patients with S lugdunensis bacteremia.…”

mentioning

confidence: 99%

Staphylococcus lugdunensis Peritoneal Dialysis-Related Peritonitis: A Matched Comparative Analysis

Fung,

SZE,

Szeto

et al. 2024

Kidney Medicine

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Staphylococcus lugdunensis Skin Infection: Report of 16 Cases

Cited by 3 publications

References 18 publications

Searching for Virulence Factors among Staphylococcus lugdunensis Isolates from Orthopedic Infections: Correlation of β-hemolysin, hemolysin III, and slush Genes with Hemolytic Activity and Synergistic Hemolytic Activity

Searching for Virulence Factors among Staphylococcus lugdunensis Isolates from Orthopedic Infections: Correlation of β-hemolysin, hemolysin III, and slush Genes with Hemolytic Activity and Synergistic Hemolytic Activity

Isolation and Identification of Staphylococcus Species Obtained from Healthy Companion Animals and Humans

Staphylococcus lugdunensis Peritoneal Dialysis-Related Peritonitis: A Matched Comparative Analysis

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