Star-Shaped Poly(2-ethyl-2-oxazoline) and Poly(2-isopropyl-2-oxazoline) with Central Thiacalix[4]Arene Fragments: Reduction and Stabilization of Silver Nanoparticles

Лезов, А. А.; Gubarev, A. S.; Mikhailova, M. E.; Лезова, А. А.; Mikusheva, N. G.; Калганов, В. Д.; Dudkina, M. M.; Теньковцев, А. В.; Nekrasova, T. N.; Андреева, Л. Н.; Saprykina, Natalia; Smyslov, R. Yu.; Gorshkova, Yu. E.; Романов, Д. А.; Höppener, Stephanie; Perevyazko, Igor; Цветков, Н. В.

doi:10.3390/polym11122006

Cited by 6 publications

(3 citation statements)

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“…The variety of 2-oxazoline monomers that are readily available or can easily be synthesized allows access to different polymer architectures and tuning of polymer functionality and properties [ 24 , 25 , 26 ]. Even though the PAOx appear to be generally biocompatible, this biocompatibility has to be demonstrated for all new derivatives.…”

Section: Introductionmentioning

confidence: 99%

Conformational Parameters and Hydrodynamic Behavior of Poly(2-Methyl-2-Oxazoline) in a Broad Molar Mass Range

et al. 2023

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In this work, we report our results on the hydrodynamic behavior of poly(2-methyl-2-oxazoline) (PMeOx). PMeOx is gaining significant attention for use as hydrophilic polymer in pharmaceutical carriers as an alternative for the commonly used poly(ethylene glycol) (PEG), for which antibodies are found in a significant fraction of the human population. The main focus of the current study is to determine the hydrodynamic characteristics of PMeOx under physiological conditions, which serves as basis for better understanding of the use of PMeOx in pharmaceutical applications. This goal was achieved by studying PMeOx solutions in phosphate-buffered saline (PBS) as a solvent at 37 °C. This study was performed based on two series of PMeOx samples; one series is synthesized by conventional living cationic ring-opening polymerization, which is limited by the maximum chain length that can be achieved, and a second series is obtained by an alternative synthesis strategy based on acetylation of well-defined linear poly(ethylene imine) (PEI) prepared by controlled side-chain hydrolysis of a defined high molar mass of poly(2-ethyl-2-oxazoline). The combination of these two series of PMeOx allowed the determination of the Kuhn–Mark–Houwink–Sakurada equations in a broad molar mass range. For intrinsic viscosity, sedimentation and diffusion coefficients, the following expressions were obtained: η=0.015M0.77, s0=0.019M0.42 and D0=2600M−0.58, respectively. As a result, it can be concluded that the phosphate-buffered saline buffer at 37 °C represents a thermodynamically good solvent for PMeOx, based on the scaling indices of the equations. The conformational parameters for PMeOx chains were also determined, revealing an equilibrium rigidity or Kuhn segment length, (A) of 1.7 nm and a polymer chain diameter (d) of 0.4 nm. The obtained value for the equilibrium rigidity is very similar to the reported values for other hydrophilic polymers, such as PEG, poly(vinylpyrrolidone) and poly(2-ethyl-2-oxazoline), making PMeOx a relevant alternative to PEG.

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Section: Introductionmentioning

confidence: 99%

Conformational Parameters and Hydrodynamic Behavior of Poly(2-Methyl-2-Oxazoline) in a Broad Molar Mass Range

et al. 2023

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“…This behavior was explained by the increased entropic penalty for biomolecule adsorption on the cyclic chains. Other PAOXA topologies have been investigated, including star-shaped PAOXA coatings (Figure 2c) [40]. The star-shaped polymers stabilized Ag NPs as potential hydrophobic drug carriers.…”

Section: Recent Advances In Polymer Coating Of Inorganic Nanoparticlesmentioning

confidence: 99%

Polymer functionalization of inorganic nanoparticles for biomedical applications

Komsthöft

Bovone

Bernhard

et al. 2022

Current Opinion in Chemical Engineering

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“…This makes PiPrOx a good candidate for the design of thermoresponsive polyoxazoline-based polymer that can undergo a phase transition in pure water, i.e. , from a dispersible state at low temperature to a collapse state at different conditions. − This work focuses on the design, synthesis, and characterization of a new macromolecule that has been developed to perform a pre-determined action in aqueous solution. In particular, we compare theoretical predictions to experimental realizations and characterizations with the aim of highlighting the main features that render a spherical core–shell polymeric nanoparticle an efficient adsorbing system.…”

Section: Introductionmentioning

confidence: 99%

Theoretical and Experimental Design of Heavy Metal-Mopping Magnetic Nanoparticles

Roma

Corsi

Willinger

et al. 2021

ACS Appl. Mater. Interfaces

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Herein, we show a comprehensive experimental, theoretical, and computational study aimed at designing macromolecules able to adsorb a cargo at the nanoscale. Specifically, we focus on the adsorption properties of star diblock copolymers, i.e. , macromolecules made by a number f of H-T diblock copolymer arms tethered on a central core; the H monomeric heads, which are closer to the tethering point, are attractive toward a specific target, while the T monomeric tails are neutral to the cargo. Experimentally, we exploited the adaptability of poly(2-oxazoline)s (POxs) to realize block copolymer-coated nanoparticles with a proper functionalization able to interact with heavy metals and show or exhibit a thermoresponsive behavior in aqueous solution. We here present the synthesis and analysis of the properties of a high molecular mass block copolymer featured by (i) a polar side chain, capable of exploiting electrostatic and hydrophilic interaction with a predetermined cargo, and (ii) a thermoresponsive scaffold, able to change the interaction with the media by tuning the temperature. Afterward, the obtained polymers were grafted onto iron oxide nanoparticles and the thermoresponsive properties were investigated. Through isothermal titration calorimetry, we then analyzed the adsorption properties of the synthesized superparamagnetic nanoparticles for heavy metal ions in aqueous solution. Additionally, we use a combination of scaling theories and simulations to link equilibrium properties of the system to a prediction of the loading properties as a function of size ratio and effective interactions between the considered species. The comparison between experimental results on adsorption and theoretical prediction validates the whole design process.

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Star-Shaped Poly(2-ethyl-2-oxazoline) and Poly(2-isopropyl-2-oxazoline) with Central Thiacalix[4]Arene Fragments: Reduction and Stabilization of Silver Nanoparticles

Cited by 6 publications

References 52 publications

Conformational Parameters and Hydrodynamic Behavior of Poly(2-Methyl-2-Oxazoline) in a Broad Molar Mass Range

Conformational Parameters and Hydrodynamic Behavior of Poly(2-Methyl-2-Oxazoline) in a Broad Molar Mass Range

Polymer functionalization of inorganic nanoparticles for biomedical applications

Theoretical and Experimental Design of Heavy Metal-Mopping Magnetic Nanoparticles

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