Star volume of marrow space and trabeculae in iliac crest: Sampling procedure and correlation to star volume of first lumbar vertebra

Vesterby, A.

doi:10.1016/8756-3282(90)90208-g

Cited by 102 publications

(34 citation statements)

References 36 publications

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“…In the biomedical setting, image analysis has been used extensively by investigators to examine trabecular bone microstructure from samples that are processed as thin sections (Amling et al, 1996;Compston et al, 1987;Croucher et al, 1996;Garrahan et al, 1986;Lundon et al, 1997;Thomsen et al, 2000;Vesterby, 1990), photographs of thick sections (Bergot et al, 1988;Twomey et al, 1983), computed tomography (CT) images (Gordon et al, 1998), and X-rays images (Geraets et al, 1990(Geraets et al, , 1993Grynpas et al, 1992Grynpas et al, , 1994. Although the different methods of obtaining images are not directly comparable, the different images provide similar information on trabecular structure, and each offers different advantages.…”

Section: Assessment Of Methodologymentioning

confidence: 99%

Medieval trabecular bone architecture: The influence of age, sex, and lifestyle

Agarwal

Dumitriu

Tomlinson

et al. 2003

American J Phys Anthropol

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Osteoporosis has become a growing health concern in developed countries and an extensive area of research in skeletal biology. Despite numerous paleopathological studies of bone mass, few studies have measured bone quality in past populations. In order to examine age- and sex-related changes in one aspect of bone quality in the past, a study was made of trabecular bone architecture in a British medieval skeletal sample. X-ray images of 5-mm-thick coronal lumbar vertebral bone sections were taken from a total of 54 adult individuals divided into three age categories (18-29, 30-49, and 50+ years), and examined using image analysis to evaluate parameters related to trabecular bone structure and connectivity. Significant age-related changes in trabecular bone structure (trabecular bone volume (BV/TV), trabecular number (Tb.N), trabecular separation (Tb.Sp), and anisotropic ratio (Tb.An)) were observed to occur primarily by middle age with significant differences between the youngest and two older age groups. Neither sex showed continuing change in trabecular structure between the middle and old age groups. Age-related changes in bone connectivity (number of nodes (N.Nd) and node-to-node strut length (Nd.Nd)) similarly indicated a change in bone connectivity only between the youngest and two older age groups. However, females showed no statistical differences among the age groups in bone connectivity. These patterns of trabecular bone loss and fragility contrast with those generally found in modern populations that typically report continuing loss of bone structure and connectivity between middle and old age, and suggest greater loss in females. The patterns of bone loss in the archaeological samples must be interpreted cautiously. We speculate that while nutritional factors may have initiated some bone loss in both sexes, physical activity could have conserved bone architecture in old age in both sexes, and reproductive factors such as high parity and extended periods of lactation could have played a key role in female bone maintenance in this historic population. The study of qualitative elements (such as trabecular architecture) is vital if we are to understand bone maintenance and fragility in the past.

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Section: Assessment Of Methodologymentioning

confidence: 99%

Medieval trabecular bone architecture: The influence of age, sex, and lifestyle

Agarwal

Dumitriu

Tomlinson

et al. 2003

American J Phys Anthropol

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“…Static histomorphometry was performed by custom-made software, which has previously been described in details [18]. The following parameters were measured: 2D trabecular bone volume BV/TV 2D ; marrow and bone space star volume V * m.space and V * b.space [19]; trabecular thickness Tb.Th, trabecular number Tb.N, and trabecular separation Tb.Sp [20]; node-terminus ratio Nd/Tm [21]; trabecular bone pattern factor TBPf [22]; and connectivity density CD [23]. For every analyzed section, a 2D region of interest (ROI) was selected to match its corresponding 3D VOI, which is chosen as described in Section 3.1.…”

Section: Histomorphometrymentioning

confidence: 99%

“…We used standardized volumes of interest (VOI) in order to compare the structure of different biopsies, performed quantitative assessments, and made comparisons of the bone architecture as well as of the amount of bone material from different tibia biopsies. In order to justify the approach, the measures of complexity of the bone architecture were compared with the results of traditional 2D bone histomorphometry [17][18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Quantification of spatial structure of human proximal tibial bone biopsies using 3D measures of complexity

et al. 2005

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Changes in trabecular bone composition during development of osteoporosis are used as a model for bone loss in microgravity conditions during a space flight. Symbolic dynamics and measures of complexity are proposed and applied to assess quantitatively the structural composition of bone tissue from 3D data sets of human tibia bone biopsies acquired by a micro-CT scanner. In order to justify the newly proposed approach, the measures of complexity of the bone architecture were compared with the results of traditional 2D bone histomorphometry. The proposed technique is able to quantify the structural loss of the bone tissue and may help to diagnose and to monitor changes in bone structure of patients on Earth as well as space-flying personnel.

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“…According to the literature, various measuring techniques are described to determine the amount of new bone formation and bone metabolism in general [Eriksen 1986;Charles et al, 1987;Parfitt et al, 1987;Vesterby, 1990]. Digital CT and X-ray images or histological sections are frequently used to quantify the amount of bone formation [Mohr et al, 2003;Shinkai et al, 2004;Rawlinson et al, 2005] Image Solutions IMSOL, Standish, Wigan (UK), Image Science Software, Berlin (Germany) and Imagic Bildverarbeitung, Glattbrugg (Switzerland)].…”

Section: Discussionmentioning

confidence: 99%

Digital Measurements: A Different Approach to Evaluate Bone Formation

Gordjestani¹,

Dermaut²,

Ridder

et al. 2006

Cells Tissues Organs

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In this study a digital measurement technique has been proposed to quantify bone formation on histological images. Two standard parietal defects were created in 30 adult rabbits. The animals were divided into six groups. Four animals of each group were randomly chosen as experimental group in which osteopontin-coated hydroxyapatite (OPN-HA) and hydroxyapatite (HA) were inserted alternatively in created defects. To observe the spontaneous healing process of defects, one animal of each group was used as control animal and these created defects did not receive any implants. The animals were sacrificed after 1, 2, 6, 12, 18 and 30 weeks. The histological sections were magnified (×100) and scanned digitally. The newly formed bone surfaces within the healing area were indicated and quantified by means of Adobe Photoshop® 7 software. This measuring technique was found to be reliable and reproducible. The results of this study show no significant differences in bone formation between the OPN-HA and non-coated HA defects, although a significant difference in bone formation was measured at the margins of the defects treated with OPN-HA.

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Star volume of marrow space and trabeculae in iliac crest: Sampling procedure and correlation to star volume of first lumbar vertebra

Cited by 102 publications

References 36 publications

Medieval trabecular bone architecture: The influence of age, sex, and lifestyle

Medieval trabecular bone architecture: The influence of age, sex, and lifestyle

Quantification of spatial structure of human proximal tibial bone biopsies using 3D measures of complexity

Digital Measurements: A Different Approach to Evaluate Bone Formation

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