Starch-based magnetic nanocomposite for targeted delivery of hydrophilic bioactives as anticancer strategy

Sousa, Alexandre C.C.; Romo, Adolfo I. B.; Almeida, Raimundo Rafael de; Silva, Aiêrta C.C.; Fechine, Lillian Maria Uchôa Dutra; Brito, Débora Hellen Almeida de; Freire, Rafael M.; Pinheiro, Daniel Pascoalino; Silva, Larissa Morais Ribeiro da; Pessoa, Otília Deusdênia Loiola; Denardin, Juliano C.; Pessoa, Cláudia; Ricardo, Nágila Maria Pontes Silva

doi:10.1016/j.carbpol.2021.118017

Cited by 19 publications

(7 citation statements)

References 34 publications

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“…Such carbon-encapsulated magnetite nanomaterials have the potential for diverse applications in various fields. They can be used as drug carriers in targeted drug delivery therapeutic systems [ 57 , 58 ], anodes materials in the construction of electrochemical lithium-ion batteries [ 59 ], microwave absorbing material for the treatment of microwave radiation pollution [ 60 , 61 , 62 , 63 ], and coolants for heat transfer applications in various systems (e.g., automobile radiators, refrigerators, electronic devices, solar energy heaters, etc.) [ 56 ].…”

Section: Resultsmentioning

confidence: 99%

Comparison of the Surface Properties of Hydrothermally Synthesised Fe3O4@C Nanocomposites at Variable Reaction Times

Sani

Adnan

et al. 2021

Nanomaterials

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The influence of variable reaction time (tr) on surface/textural properties (surface area, total pore volume, and pore diameter) of carbon-encapsulated magnetite (Fe3O4@C) nanocomposites fabricated by a hydrothermal process at 190 °C for 3, 4, and 5 h was studied. The properties were calculated using the Brunauer–Emmett–Teller (BET) isotherms data. The nanocomposites were characterised using Fourier transform infrared spectroscopy, X-ray diffraction analysis, thermogravimetry, and scanning and transmission electron microscopies. Analysis of variance shows tr has the largest effect on pore volume (F value = 1117.6, p value < 0.0001), followed by the surface area (F value = 54.8, p value < 0.0001) and pore diameter (F value = 10.4, p value < 0.001) with R2-adjusted values of 99.5%, 88.5% and 63.1%, respectively. Tukey and Fisher tests confirmed tr rise to have caused increased variations in mean particle sizes (11–91 nm), crystallite sizes (5–21 nm), pore diameters (9–16 nm), pore volume (0.017–0.089 cm3 g−1) and surface area (7.6–22.4 m2 g−1) of the nanocomposites with individual and simultaneous confidence limits of 97.9 and 84.4 (p-adj < 0.05). The nanocomposites’ retained Fe–O vibrations at octahedral (436 cm−1) and tetrahedral (570 cm−1) cubic ferrite sites, modest thermal stability (37–60% weight loss), and large volume-specific surface area with potential for catalytic application in advanced oxidation processes.

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Section: Resultsmentioning

confidence: 99%

Comparison of the Surface Properties of Hydrothermally Synthesised Fe3O4@C Nanocomposites at Variable Reaction Times

Sani

Adnan

et al. 2021

Nanomaterials

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“…Sousa et al 67 conducted a co-encapsulation synthesis to merge oncocalyxone A (onco A) and magnetite nanoparticles (Fe 3 O 4 @citrate) with modified surfaces, forming a unified nanostructure. The nanocapsules obtained displayed a core–shell structure and possessed an average diameter of 143 nm.…”

Section: Polysaccharide-based Nanogels For Drug Deliverymentioning

confidence: 99%

Smart stimuli-responsive polysaccharide nanohydrogels for drug delivery: a review

Damiri,

Fatimi,

Santos

et al. 2023

J. Mater. Chem. B

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“…Sousa et al. demonstrated that starch‐based magnetic nanocapsules having core‐shell morphology with an average diameter of 143 nm affected the cell membrane leading to cell lysis in human tumor cell lines (Sousa et al., 2021).…”

Section: Nano‐bio Interactions Of Bioactive Ndssmentioning

confidence: 99%

“…reported the α-glucanotransferase (α-GTase)-treated rice starch (GS) prepared by treating rice starch with 4α-GTase for 1 h (1 GS) and 96 h (96 GS) to improve the encapsulation efficiency and stability of curcumin. Accordingly, the flaky rod-like structures helped in increased curcumin solubility by 2241-and 2846-fold, respectively(Park et al, 2019).Sousa et al demonstrated that starch-based magnetic nanocapsules having coreshell morphology with an average diameter of 143 nm affected the cell membrane leading to cell lysis in human tumor cell lines(Sousa et al, 2021).…”

mentioning

confidence: 99%

Interactions of plant food bioactives‐loaded nano delivery systems at the nano‐bio interface and its pharmacokinetics: An overview

et al. 2022

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Plant food bioactives (PFBs) offer immense health benefits with a greater scope for treating various life‐threatening diseases and lifestyle disorders. Knowing their therapeutic potentials, a lot of research works are being carried out on formulating PFBs‐loaded nano delivery systems (NDSs) to enhance their bioefficacy. However, limited information are available on the interactions occurring at the nano‐bio interface. Therefore, studies on nano‐bio interactions are of immense importance towards designing/formulating effective NDSs for PFBs. Understanding the significance of nano‐bio interface of food bioactive‐loaded NDSs would help us to predict the formation of biocorona as well as the correlation between the nanoparticles and their surrounding environments that are influenced by the NDS's physicochemical properties. The physicochemical characteristics of NDSs like size, shape, and surface charge will decide their fate in the biological fluids and have been discussed in detail. As the bioactives‐loaded NDS enters the gastrointestinal tract, formation of biocorona including protein and enzyme corona at the nano‐bio interface will takes place. Subsequently, the fate of PFBs‐loaded NDSs influences the absorption, distribution, metabolism, and excretion (ADME) processes and thereby its bioavailability, bioefficacy, and biosafety. The current review focuses on understanding the journey of PBFs‐loaded NDSs, the nature of interactions happening at nano‐bio interface, and its pharmacokinetics properties. In addition, a specific case study approach on curcumin‐loaded NDSs, and its reported interactions at nano‐bio interface, including ADME mechanism are comprehensively presented.

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Starch-based magnetic nanocomposite for targeted delivery of hydrophilic bioactives as anticancer strategy

Cited by 19 publications

References 34 publications

Comparison of the Surface Properties of Hydrothermally Synthesised Fe3O4@C Nanocomposites at Variable Reaction Times

Comparison of the Surface Properties of Hydrothermally Synthesised Fe3O4@C Nanocomposites at Variable Reaction Times

Smart stimuli-responsive polysaccharide nanohydrogels for drug delivery: a review

Interactions of plant food bioactives‐loaded nano delivery systems at the nano‐bio interface and its pharmacokinetics: An overview

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