Starch nanocrystals based hydrogel: Construction, characterizations and transdermal application

Bakrudeen, Haja Bava; Sudarvizhi, C.; Reddy, B. S. R.

doi:10.1016/j.msec.2016.07.018

Cited by 53 publications

(13 citation statements)

References 31 publications

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“…Zeta potential is a parameter that indicates the degree of repulsion between adjacent particles loaded in a similar way; therefore, zeta‐potential measurements are used to estimate the electrical stability of nanoparticle suspensions. Zhou et al .…”

Section: Resultsmentioning

confidence: 99%

“…From this perspective, nanotechnology has been an important ally for the development of these new materials . Nanoscale particles usually have a large surface area per unit mass, allowing a great interaction capacity, which makes them capable of acting as important mechanical reinforcement loads …”

Section: Introductionmentioning

confidence: 99%

“…From this perspective, nanotechnology has been an important ally for the development of these new materials. [5][6][7] Nanoscale particles usually have a large surface area per unit mass, allowing a great interaction capacity, which makes them capable of acting as important mechanical reinforcement loads. 8 In addition, nanomaterials have been extensively investigated, especially those derived from natural polymers such as cellulose 2,4,9 and starch.…”

Section: Introductionmentioning

confidence: 99%

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Morphological, barrier, and mechanical properties of cassava starch films reinforced with cellulose and starch nanoparticles

Santana

Costa

Rodrigues

et al. 2018

J of Applied Polymer Sci

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A comparative performance study of cellulose and starch nanoparticles on plasticized starch reinforcement has been presented. Starch nanoparticles were obtained by ultrasound and acid hydrolysis, and cellulose nanoparticles were extracted by acid hydrolysis from microcrystalline cellulose and sisal fibers. The nanoparticles were characterized according to the zeta potential, the particle‐size distribution, transmission electron microscopy, X‐ray diffraction, and thermogravimetric analysis. The influence of the addition of these nanoparticles to starch films on the morphology, water vapor permeability (WVP), and mechanical properties of the nanocomposites films were investigated. The cellulose nanoparticles exhibited higher electrical stability than those originating from starch. Acid hydrolysis produced starch nanoparticles with higher crystallinity than ultrasound. All the nanoparticles significantly reduced the WVP. The cellulose nanoparticles significantly increased the tensile strength of the starch films; however, they reduced the flexibility of the nanocomposites. The results of this work support the application of starch and cellulose nanostructures for the development of reinforced biodegradable materials. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47001.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Morphological, barrier, and mechanical properties of cassava starch films reinforced with cellulose and starch nanoparticles

Santana

Costa

Rodrigues

et al. 2018

J of Applied Polymer Sci

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“…Korsmeyer‐Peppas

M t / M_{normal∞} = k_{normalo} t^{normaln}

where C o , C , and k o are the initial concentration of drug, final concentration of drug, and release rate constant of drug release at time ( t ), respectively. Mt/ M ∞ is the fraction of drug released at time ( t ), and n is the release exponent that can be determined from the linear regression of log (Mt/ M ∞ ) versus log t …”

Section: Methodsmentioning

confidence: 99%

pH‐Responsive Starch‐Citrate Nanoparticles for Controlled Release of Paracetamol

et al. 2019

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Starch‐citrate samples with degrees of substitution (DS) ranging from 0.11 to 0.90 are synthesized by a green esterification reaction between citric acid and native sago starch (Metroxylon sagu) in an aqueous medium. Starch‐citrate nanoparticles with mean diameter of 105 nm are subsequently obtained by controlled precipitation through drop‐wise addition of dissolved starch‐citrate solution into excess absolute ethanol. These nanoparticles are observed to exhibit pH‐responsive release profiles within the physiological pH range of 1.2–8.6. The release profile of a model drug (paracetamol) is observed to obey the zero‐order kinetics, with the release mechanism based on the diffusion and swelling model. The cytotoxicity study in HaCaT cell lines (human skin cells) shows that starch‐citrate nanoparticles are non‐toxic and hence are suitable for biomedical applications as pH‐responsive drug carriers.

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“…They have put the focus on the penetration of ultra-small NPs into skin strata, the targeted delivery of the encapsulated APIs to hair follicle stem cells, and the combination of NPs and microneedle array technologies for special applications, such as vaccine delivery. Recent literature has demonstrated that NP-based DDSs for topical application can be very successful due to the chemical and physical protection of drug used, controlled release, and cell and tissue-specific targeting [11,[31][32][33]. These systems combine the advantages of both the nanosized drug carriers and the topical approach, and are promising for the treatment of various skin diseases providing a high patient compliance.…”

Section: State-of-the-art Topical and Transdermal Drug Delivery Nano-mentioning

confidence: 99%

Synthetic Polymer-Based Nanoparticles: Intelligent Drug Delivery Systems

Andonova¹

2017

Acrylic Polymers in Healthcare

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One of the most promising strategies to improve the bioavailability of active pharmaceutical ingredients is based on the association of the drug with colloidal carriers, for example, polymeric nanoparticles, which are stable in biological environment, protective for encapsulated substances and able to modulate physicochemical characteristics, drug release and biological behaviour. The synthetic polymers possess unique properties due to their chemical structure. Some of them are characterized with mucoadhesiveness; another can facilitate the penetration through mucous layers; or to be stimuli responsive, providing controlled drug release at the target organ, tissues or cells; and all of them are biocompatible and versatile. These are suitable vehicles of nucleic acids, oligonucleotides, DNA, peptides and proteins. This chapter aims to look at the 'hot spots' in the design of synthetic polymer nanoparticles as an intelligent drug delivery system in terms of biopharmaceutical challenges and in relation to the route of their administration: the non-invasive-oral, transdermal, transmucosal (nasal, buccal/sublingual, vaginal, rectal and ocular) and inhalation routes-and the invasive parenteral route.

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Starch nanocrystals based hydrogel: Construction, characterizations and transdermal application

Cited by 53 publications

References 31 publications

Morphological, barrier, and mechanical properties of cassava starch films reinforced with cellulose and starch nanoparticles

Morphological, barrier, and mechanical properties of cassava starch films reinforced with cellulose and starch nanoparticles

pH‐Responsive Starch‐Citrate Nanoparticles for Controlled Release of Paracetamol

Synthetic Polymer-Based Nanoparticles: Intelligent Drug Delivery Systems

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