Starch structure modulates metabolic activity and gut microbiota profile

Zhou, Zhongkai; Zhang, Yan; Zheng, Paiyun; Chen, Xiaoshan; Yang, Yan

doi:10.1016/j.anaerobe.2013.09.012

Cited by 39 publications

(22 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, the regulation of blood lipids composition is even more complex than we have recognized. For example, the remarkable suppression of the elevated total cholesterol levels caused by RS consumption might also be associated with increased levels of the bacterial populations in the gut as well [6,21], because our previous studies suggested that the RS administration greatly increased the short-chain fatty acids via gut microbiota fermentation, in particular, propionate and butyrate [22,23], and these metabolites exhibited the inhibition of cholesterols synthesis in the livers [24].…”

Section: Discussionmentioning

confidence: 97%

Resistant starch manipulated hyperglycemia/hyperlipidemia and related genes expression in diabetic rats

Zhou

Wang

Ren

et al. 2015

International Journal of Biological Macromolecules

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 97%

Resistant starch manipulated hyperglycemia/hyperlipidemia and related genes expression in diabetic rats

Zhou

Wang

Ren

et al. 2015

International Journal of Biological Macromolecules

Self Cite

View full text Add to dashboard Cite

“…Dietary studies have found that, in healthy subjects, Faecalibacterium increased secondary to prebiotic supplementation, including, inulin (48), raffinose (49), polydextrose (50), soluble corn fiber (50) high amylose maize starch (51), resistant maltodextrin (52), and the pro-biotic, Bacillus coagulans (53). However, bipolar subjects have a high incidence of comorbid gastrointestinal disorders, which are sensitive to the many of the above supplementations so other dietary approaches should be investigated for this population.…”

Section: Discussionmentioning

confidence: 99%

The gut microbiome composition associates with bipolar disorder and illness severity

Evans

Bassis

Hein

et al. 2017

Journal of Psychiatric Research

251

181

View full text Add to dashboard Cite

The gut microbiome is emerging as an important factor in regulating mental health yet it remains unclear what the target should be for psychiatric treatment. We aimed to elucidate the complement of the gut-microbiome community for individuals with bipolar disorder relative to controls; and test for relationships with burden of disease measures. We compared the stool microbiome from individuals with bipolar disorder (n=115) and control subjects (n=64) using 16S ribosomal RNA (rRNA) gene sequence analysis. Analysis of molecular variance (AMOVA) revealed global community case-control differences (AMOVA p=0.047). Operational Taxonomical Unit (OTU) level analysis revealed significantly decreased fractional representation (p<0.001) of Faecalibacterium after adjustment for age, sex, BMI and false discovery rate (FDR) correction at the p<0.05 level. Within individuals with bipolar disorder, the fractional representation of Faecalibacterium associated with better self-reported health outcomes based on the Short Form Health Survey (SF12); the Patient Health Questionnaire (PHQ9); the Pittsburg Sleep Quality Index (PSQI); the Generalized Anxiety Disorder scale (GAD7); and the Altman Mania Rating Scale (ASRM), independent of covariates. This study provides the first detailed analysis of the gut microbiome relationships with multiple psychiatric domains from a bipolar population. The data support the hypothesis that targeting the microbiome may be an effective treatment paradigm for bipolar disorder.

show abstract

“…However, as our knowledge of gut microbiota improves, it seems that other microorganisms could benefit from prebiotic administration, such as Clostridium coccoides or the Eubacterium rectale cluster, which includes bacteria-producing butyric acid, a beneficial metabolite for gut functionality that is potentially protective against bowel cancer [10,23]. Interestingly, some degradation products of prebiotics are able to promote beneficial effects [151,152] and to have protective effects on colonic epithelial cells during the progression of colorectal cancer, inhibiting the nuclear factor kappa B activation and the histone deacetylation [153]. Butyrate seems to have a protective effect in the prevention of colonic cancer cell proliferation by provoking apoptosis through the induction of autophagy and by blocking the endoplasmic reticulum stress response [154].…”

Section: Prebiotics and Gastrointestinal Disordersmentioning

confidence: 99%

Mechanisms of Action of Prebiotics and Their Effects on Gastro-Intestinal Disorders in Adults

et al. 2020

View full text Add to dashboard Cite

In recent years, research has focused on the use of dietary fibers and prebiotics, since many of these polysaccharides can be metabolized by intestinal microbiota, leading to the production of short-chain fatty acids. The metabolites of prebiotic fermentation also show anti-inflammatory and immunomodulatory capabilities, suggesting an interesting role in the treatment of several pathological conditions. Galacto-oligosaccharide and short-and long-chain fructans (Fructo-oligosaccharides and inulin) are the most studied prebiotics, even if other dietary compounds seem to show the same features. There is an increasing interest in dietary strategies to modulate microbiota. The aim of this review is to explore the mechanisms of action of prebiotics and their effects on the principal gastro-intestinal disorders in adults, with a special focus on Galacto-oligosaccharides, Fructo-oligosaccharides, lactulose and new emerging substances which currently have evidence of prebiotics effects, such as xilooligosaccharides, soybean oligosaccharides, isomaltooligosaccharides, lactobionic acid, resistant starch and polyphenols.

show abstract

Starch structure modulates metabolic activity and gut microbiota profile

Cited by 39 publications

References 26 publications

Resistant starch manipulated hyperglycemia/hyperlipidemia and related genes expression in diabetic rats

Resistant starch manipulated hyperglycemia/hyperlipidemia and related genes expression in diabetic rats

The gut microbiome composition associates with bipolar disorder and illness severity

Mechanisms of Action of Prebiotics and Their Effects on Gastro-Intestinal Disorders in Adults

Contact Info

Product

Resources

About