Stasis Dermatitis: An Overview of Its Clinical Presentation, Pathogenesis, and Management

Yosipovitch, Gil; Nedorost, Susan; Silverberg, Jonathan I.; Friedman, Adam; Canosa, Juliana M; Cha, Amy

doi:10.1007/s40257-022-00753-5

Cited by 18 publications

(5 citation statements)

References 68 publications

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“…Additionally, another patient utilized a combination of high-potency steroids and tape due to insurance-related considerations. When stasis dermatitis is suspected, the use of compression and elevation is often beneficial [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Squamous Cell Carcinoma Mimickers: Beware the Pruritic Papule on the Leg of an Older Female

Kubicki¹,

Hansen²,

MacFarlane³

2023

Cureus

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Background Correctly identifying cutaneous squamous cell carcinoma (cSCC) mimickers can be both clinically and histopathologically challenging. We present a series of patients with biopsy-proven cSCCs for whom multiple surgeries were avoided by assessing the clinical situation, recognizing an alternative diagnosis that pathologically mimics cSCC, and prescribing appropriate therapy for the underlying condition. Methodology Seven female patients presented for treatment of biopsy-proven cSCC affecting the lower leg. After further investigation, we observed that these women shared similar characteristics, including age ranging from the 5th to the 9th decade, often experiencing stress, exhibiting associated pruritus with diverse causes, having few or no previous skin cancers, and generally showing minimal photodamage. Results In all cases, surgery was deferred and patients demonstrated complete clinical response to therapies directed toward an alternative diagnosis. Repeat biopsies of treated lesions revealed no evidence of cSCC. Conclusions Not all histologically diagnosed cases of cSCC should be treated with surgery, and each patient should be worked up thoroughly to evaluate for an alternative diagnosis. Possible clinical and histologic cSCC mimickers include allergic contact dermatitis (ACD), stasis dermatitis, hypertrophic lichen planus (LP), and drug eruption, among others. In the described population, pruritic papules on the lower leg should prompt further investigation to prevent the morbidity associated with unnecessary surgery.

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Section: Discussionmentioning

confidence: 99%

Cutaneous Squamous Cell Carcinoma Mimickers: Beware the Pruritic Papule on the Leg of an Older Female

Kubicki¹,

Hansen²,

MacFarlane³

2023

Cureus

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“…Hemoglobin from these erythrocytes subsequently decomposes into hemosiderin, an insoluble complex of iron which induces an influx of macrophages attracted via hemoglobin scavenger receptor CD163. The accumulating macrophages secrete proteolytic enzymes and proinflammatory cytokines that induce skin damage which manifests as spongiosis in the epidermis, in addition to the fibrosis and neogenesis of capillary vessels in the dermis [ 130 , 131 ]. A macrophage mediator pivotal to stasis dermatitis is interleukin-31 (IL-31), which can directly evoke pruritus via the interleukin-31 receptor A (IL-31RA) present on peripheral nerves.…”

Section: An Overview Of Diseases From the Spectrummentioning

confidence: 99%

Diseases from the Spectrum of Dermatitis and Eczema: Can “Omics” Sciences Help with Better Systematics and More Accurate Differential Diagnosis?

Śpiewak

2023

IJMS

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Researchers active in the field of inflammatory skin diseases from the spectrum of dermatitis and eczema are well aware of a considerable overlap in the clinical pictures and proposed sets of diagnostic criteria for these diseases, which can hardly be overcome through the clinical or epidemiological research. In effect, patients are included in studies based on vague and overlapping criteria, while heterogeneous study populations may, in turn, lead to non-representative outcomes and continued confusion. In this narrative review, a systematics of diseases from the spectrum of dermatitis and eczema is proposed based on the origins of causative factors and the pathomechanisms involved. Difficulties in differentiating between these diseases are discussed, and the extent to which advances in the “omics” sciences might help to overcome them is considered. Of all the “omics” research in this field, more than 90% of the published papers were devoted to atopic dermatitis, with a striking underrepresentation of other diseases from the spectrum of dermatitis and eczema, conditions which collectively exceed the rates of atopic dermatitis by far. A greater “omics” research effort is urgently needed to tackle other dermatitides, like allergic, irritant and protein contact dermatitis, as well as radiation, seborrheic, stasis or autoimmune dermatitis. Atopic dermatitis findings should be validated not only against healthy donors but also other dermatitides. A clinic-oriented approach is proposed for future “omics” studies in the field of dermatitis and eczema.

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“…Compression therapy, using bandages or stockings (high pressure 60mmHg or median pressure 30 mmHg), is an important part of therapy if the patient is able to tolerate the treatment while other non-pharmacological options include exercise, leg elevation and Unna boot (dressings). 30…”

Section: Eczema/dermatitismentioning

confidence: 99%

Dermatological Issues Among Individuals Receiving Palliative Care - A Review

Kwan,

Han,

Yong

et al. 2023

Am J Hosp Palliat Care

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Skin disorders among individuals receiving palliative care may be associated with the primary condition or underlying comorbidities and patients may experience pruritus, discomfort or pain. Common conditions include xerosis, pressure ulcers, intertrigo, superficial fungal infections, telogen effluvium, pruritus, herpes zoster, eczematous disorders and edema. During end-of-life care, there is reduced skin perfusion and metabolism hence leading to susceptibility to infection, pressure and injury. Other factors affecting the skin include limited mobility, nutritional deficits and immunosuppression. Although treatment strategies for each skin condition are usually aligned with standard protocols, considerations among these patients include limited life-expectancies, potential treatment burden, drug-drug interactions as well as comfort-directed rather than cure-directed therapy. For patients with xerosis cutis, the regular use of moisturisers is recommended. The management and prevention of pressure ulcers include the strategies of skin assessment and care, pressure redistribution, nutrition and hydration and ulcer care. Superficial fungal infections require treatment with appropriate topical and/or systemic antifungals while antivirals and adjunctive treatment can be prescribed for herpes zoster. Treatment and symptom control of skin disorders in this population can improve quality of life and patients’ comfort level.

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Stasis Dermatitis: An Overview of Its Clinical Presentation, Pathogenesis, and Management

Cited by 18 publications

References 68 publications

Cutaneous Squamous Cell Carcinoma Mimickers: Beware the Pruritic Papule on the Leg of an Older Female

Cutaneous Squamous Cell Carcinoma Mimickers: Beware the Pruritic Papule on the Leg of an Older Female

Diseases from the Spectrum of Dermatitis and Eczema: Can “Omics” Sciences Help with Better Systematics and More Accurate Differential Diagnosis?

Dermatological Issues Among Individuals Receiving Palliative Care - A Review

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