2010
DOI: 10.1016/j.jss.2009.03.049
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Stasis Predisposes Ileal Pouch Inflammation in a Rat Model of Ileal Pouch-Anal Anastomosis

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Cited by 11 publications
(13 citation statements)
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“…The strictured ileo-anal anastomosis was performed intraoperatively. The stricture is one of the causes of pouchitis both in clinical and experimental models [16][17][18]. After one day of fasting (exclusive supply of 8% glucose solution), the animals received a semi-synthetic diet without fiber (AIN-93) in increasing doses for ten days (respectively 5, 8, 10 and 12 g/d in the following days, up to 25 g/d) [19].…”
Section: Methodsmentioning
confidence: 99%
“…The strictured ileo-anal anastomosis was performed intraoperatively. The stricture is one of the causes of pouchitis both in clinical and experimental models [16][17][18]. After one day of fasting (exclusive supply of 8% glucose solution), the animals received a semi-synthetic diet without fiber (AIN-93) in increasing doses for ten days (respectively 5, 8, 10 and 12 g/d in the following days, up to 25 g/d) [19].…”
Section: Methodsmentioning
confidence: 99%
“…Colonic metaplasia occurs to some degree in all functioning ileal pouches, although it is rarely evident in pouch mucosa, either prior to ileostomy closure [35,36] or in the terminal ileum, of patients with a unobstructed ileostomy, suggesting that stasis may predispose these morphologic changes. In the Stucchi's study [34], there is biochemical evidence of neutrophil recruitment and elevated MPO levels to the ileal pouch of IPAA animals as early as 30 days postoperatively.…”
Section: Pathophysiologymentioning
confidence: 98%
“…Both of these mechanisms can compromise epithelial integrity and barrier function, thus predisposing the ileal pouch mucosa to a low-grade inflammatory response. Both anaerobic and aerobic bacteria overgrow the ileal pouch at 30 days postoperatively [33,34].…”
Section: Pathophysiologymentioning
confidence: 99%
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“…Stucchi and colleagues [8,9] and others [10] have made an important contribution to the IBD literature by developing an animal model with a J pouch after colectomy. This is of particular importance because the authors' model reproduces some features of early pouchitis.…”
mentioning
confidence: 99%