STAT RAD: A Potential Real-Time Radiation Therapy Workflow

Wilson, Dan; Sheng, Ke; Yang, Wensha; Jones, Ryan; Read, Paul W.

doi:10.5772/34285

Cited by 4 publications

(7 citation statements)

References 50 publications

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“…The University of Virginia have implemented a rapid palliative radiotherapy technique using CT-based IGRT of TomoTherapy (Accuracy Inc, Madison, WI) with their “STAT RAD” program (2, 3). The STAT RAD workflow utilizes the on-board MVCT capabilities of TomoTherapy to simulate the patient in treatment position followed by rapid treatment plan generation, quality assurance of the plan with exit dosimetry through the on-board CT detector, and treatment delivery.…”

Section: Discussionmentioning

confidence: 99%

“…The American Cancer Society estimated that annually in 2019 there are 1.76 million new cases of cancer with 606,880 cancer deaths (1). Most cancer deaths are associated with a decreased quality of life and painful end-of-life, likely due to loco-regional or metastatic disease progression (2, 3). Palliative radiotherapy (RT) allows for the management of patients with advanced stage cancer.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…As the sensitivity and accuracy of cancer detection and subsequently cancer treatments progressively improve, the life expectancy for cancer patients is steadily rising even with metastatic disease (3). Thus, the continued management of these patients is of great importance (3). Due to multiple steps in standard radiation planning processes, palliative treatment may take 3–7 days post-consultation before the first treatment fraction is performed (3).…”

Section: Introductionmentioning

confidence: 99%

“…Thus, the continued management of these patients is of great importance (3). Due to multiple steps in standard radiation planning processes, palliative treatment may take 3–7 days post-consultation before the first treatment fraction is performed (3). Improving the palliative RT workflow by utilizing advanced technology to offer rapid, same day treatment can reduce the pre-treatment time period, allowing for near-immediate pain-relief and an improved quality of life for these patients.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

STAT-ART: The Promise and Practice of a Rapid Palliative Single Session of MR-Guided Online Adaptive Radiotherapy (ART)

et al. 2019

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This work describes a novel application of MR-guided online adaptive radiotherapy (MRgoART) in the management of patients whom urgent palliative care is indicated using statum-adaptive radiotherapy (STAT-ART). The implementation of STAT-ART, as performed at our institution, is presented including a discussion of the advantages and limitations compared to the standard of care for palliative radiotherapy on conventional c-arm linacs. MR-based treatment planning techniques of STAT-ART for density overrides and deformable image registration (DIR) of diagnostic CT to the treatment MR are also addressed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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STAT-ART: The Promise and Practice of a Rapid Palliative Single Session of MR-Guided Online Adaptive Radiotherapy (ART)

et al. 2019

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Introducing Computed Tomography Simulation–Free and Electronic Patient-Reported Outcomes–Monitored Palliative Radiation Therapy into Routine Care: Clinical Outcomes and Implementation Experience

Schuler

Back

Hruby

et al. 2021

Advances in Radiation Oncology

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Purpose Our purpose was to report outcomes of a novel palliative radiation therapy protocol that omits computed tomography simulation and prospectively collects electronic patient-reported outcomes (ePROs). Methods and Materials Patients receiving extracranial, nonstereotactic, linear accelerator-based palliative radiation therapy who met inclusion criteria (no mask-based immobilization and a diagnostic computed tomography within 4 weeks) were eligible. Global pain was scored with the 11-point numerical pain rating scale (NPRS). Patients were coded as having osseous or soft tissue metastases and no/mild versus severe baseline pain (NPRS ≥ 5). Pain response at 4 weeks was measured according to the international consensus (no analgesia adjustment). Transition to ePRO questionnaires was completed in 3 phases. Initially, pain assessments were collected on paper for 11 months, then pilot ePROs for 1 month and then, after adjustments, revised ePROs from 1 year onwards. ePRO feasibility criteria were established with reference to the paper-based process and published evidence. Results Between May 2018 and November 2019, 542 consecutive patients were screened, of whom 163 were eligible (30%), and 160 patients were successfully treated. The proportion of patients eligible for the study improved from approximately 20% to 50% by study end. Routine care pain monitoring via ePROs was feasible. One hundred twenty-seven patients had a baseline NPRS recording. Ninety-five patients had osseous (61% severe pain) and 32 had soft tissue (25% severe pain) metastases. Eighty-four patients (66%) were assessable for pain response at 4 weeks. In the 41 patients with severe osseous pain, overall and complete pain response was 78% and 22%, respectively. Conclusions By study completion, 50% of patients receiving palliative extracranial radiation therapy avoided simulation, streamlining the treatment process and maximizing patient convenience. Pain response for patients with severe pain from osseous lesions was equivalent to published evidence.

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STAT RAD: Prospective Dose Escalation Clinical Trial of Single Fraction Scan-Plan-QA-Treat Stereotactic Body Radiation Therapy for Painful Osseous Metastases

Muller

Wages

Wilson

et al. 2020

Practical Radiation Oncology

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STAT RAD: A Potential Real-Time Radiation Therapy Workflow

Cited by 4 publications

References 50 publications

STAT-ART: The Promise and Practice of a Rapid Palliative Single Session of MR-Guided Online Adaptive Radiotherapy (ART)

STAT-ART: The Promise and Practice of a Rapid Palliative Single Session of MR-Guided Online Adaptive Radiotherapy (ART)

Introducing Computed Tomography Simulation–Free and Electronic Patient-Reported Outcomes–Monitored Palliative Radiation Therapy into Routine Care: Clinical Outcomes and Implementation Experience

STAT RAD: Prospective Dose Escalation Clinical Trial of Single Fraction Scan-Plan-QA-Treat Stereotactic Body Radiation Therapy for Painful Osseous Metastases

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