2023
DOI: 10.3389/fncel.2023.1156802
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Stat1 is an inducible transcriptional repressor of neural stem cells self-renewal program during neuroinflammation

Jaime Imitola,
Ethan W. Hollingsworth,
Fumihiro Watanabe
et al.

Abstract: A central issue in regenerative medicine is understanding the mechanisms that regulate the self-renewal of endogenous stem cells in response to injury and disease. Interferons increase hematopoietic stem cells during infection by activating STAT1, but the mechanisms by which STAT1 regulates intrinsic programs in neural stem cells (NSCs) during neuroinflammation is less known. Here we explored the role of STAT1 on NSC self-renewal. We show that overexpressing Stat1 in NSCs derived from the subventricular zone (… Show more

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Cited by 7 publications
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