STAT3 inhibitor enhances chemotherapy drug efficacy by modulating mucin 1 expression in non-small cell lung carcinoma

Han, Yunguo; Lu, Xia; Guang-min, Wang

doi:10.4314/tjpr.v16i7.8

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…Research on cancer is often very interesting because of the high fatality rate of the disease is diagnosed later and or untreated. One of the methods used in the survival analysis in oncology and epidemiology studies is the Kaplan-Meier method (K-M) [ 15 ], [ 16 ], [ 17 ], [ 18 ], [ 19 ], [ 20 ], [ 21 ], [ 22 ], [ 23 ], [ 24 ]. K-M method is usually used in conjunction with Cox proportional hazard regression, immunohisto-chemistry, lognormal, hazard ratio, Chi-squared test, log-rank test and so on.…”

Section: Methodsmentioning

confidence: 99%

Survival Analysis of Cancer Patients in North Eastern Nigeria from 2004 – 2017 – A Kaplan - Meier Method

Adamu

Opoola

Bishop

2019

Open Access Maced J Med Sci

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BACKGROUND: Cancer is a deadly malignant disease and is prevalent in Sub Saharan Africa. The North East part of Nigeria in particular and the country, in general, are struggling to cope with the increasing burden of cancer and other communicable and non-communicable diseases. The situation is worsened by the ongoing insurgency and terrorist activities in the area. AIM: The aim of this paper is to present the research findings from a cohort study aimed at the analysis of the estimation of the survivorship time of the real data of cancer patients in the North-eastern part of Nigeria and to establish if the insurgency in the region has contributed negatively to the life expectancy of its inhabitants. MATERIAL AND METHODS: The record of 1,090 patients from medical records departments of the University of Maiduguri Teaching Hospital (UMTH), located in Maiduguri, the capital city of Borno State in northeast Nigeria was obtained. The record showed patients that were diagnosed and died of one type of cancer or the other from 2004 to 2017. All the cancer cases included in the present study were grouped into sex, age, marital status, occupation, date admitted and date of death/discharge. Descriptive statistics and Kaplan-Meier method were used to analyse the data using SPSS version 23 while Microsoft EXCEL and Minitab 16.0 were used for data cleansing and organisation. RESULTS: Of the 1,090 patients analysed, 920 (84.40%) experienced the event, i.e. death, while 170 (15.60%) patients were censored. The data were analysed based on the ages and sex of the patients. 50.20% of the patients were of ages 21-50 years. The proportions of patients in this age bracket surviving past 7 days are 75%, while those between ages 80 years and above is 12 days. Others are of survival time of 5 days (ages 0-20 years) and 7 days (51-79 years). Using sex, 75% of the patients’ survival time is 7 days in the case of male and 6 days for females. It is safe to say that the survival time for cancer patients of the university the Maiduguri is 6 days and the result reflects the Northeastern part of Nigeria. This is because the hospital is one of few tertiary healthcare facilities in that area and consequently, cancer cases are often referred there. CONCLUSION: Cancer incidence is high, and the probability of survival reduces as the survival time increases. This is a dire situation in need of urgent intervention from the government, groups and individuals to tackle the scourge of cancer, thereby improving on the life expectancy battered by the ongoing Boko Haram insurgency in that region.

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Section: Methodsmentioning

confidence: 99%

Survival Analysis of Cancer Patients in North Eastern Nigeria from 2004 – 2017 – A Kaplan - Meier Method

Adamu

Opoola

Bishop

2019

Open Access Maced J Med Sci

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“…In other studies, siRNA-mediated STAT3 inhibition enhanced the sensitivity of A549 and SPC-A1 NSCLC cells to cisplatin by enhancing apoptosis in a caspase-3-dependent manner [ 33 ], while the small molecule STAT3 inhibitor BBI-608 re-sensitized chemo-resistant NSCLC cells to cisplatin and inhibited cell proliferation [ 70 ]. Pharmacologic inhibition of STAT3 via administration of C188-9 also improved the response of NSCLC xenografts to cisplatin and vinblastine, and significantly reduced tumor growth in the combination-treated group compared to mice treated with single agent chemotherapies [ 273 ]. Meanwhile, treatment of EGFR-mutant NSCLC cells with the STAT3 inhibitor TPCA-1 enhanced the anti-proliferative effects of afatinib chemotherapy [ 274 ].…”

Section: Therapeutic Opportunitiesmentioning

confidence: 99%

Multicellular Effects of STAT3 in Non-small Cell Lung Cancer: Mechanistic Insights and Therapeutic Opportunities

Parakh

Ernst

Poh

2021

Cancers

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Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and accounts for 85% of lung cancer cases. Aberrant activation of the Signal Transducer and Activator of Transcription 3 (STAT3) is frequently observed in NSCLC and is associated with a poor prognosis. Pre-clinical studies have revealed an unequivocal role for tumor cell-intrinsic and extrinsic STAT3 signaling in NSCLC by promoting angiogenesis, cell survival, cancer cell stemness, drug resistance, and evasion of anti-tumor immunity. Several STAT3-targeting strategies have also been investigated in pre-clinical models, and include preventing upstream receptor/ligand interactions, promoting the degradation of STAT3 mRNA, and interfering with STAT3 DNA binding. In this review, we discuss the molecular and immunological mechanisms by which persistent STAT3 activation promotes NSCLC development, and the utility of STAT3 as a prognostic and predictive biomarker in NSCLC. We also provide a comprehensive update of STAT3-targeting therapies that are currently undergoing clinical evaluation, and discuss the challenges associated with these treatment modalities in human patients.

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Nanovaccines: An effective therapeutic approach for cancer therapy

Gurunathan,

Thangaraj,

Wang

et al. 2024

Biomedicine & Pharmacotherapy

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STAT3 inhibitor enhances chemotherapy drug efficacy by modulating mucin 1 expression in non-small cell lung carcinoma

Abstract: Purpose: To evaluate the role of signal transducer and activator of transcription 3 (STAT3) and mucin 1(MUC1) in non-

Cited by 3 publications

References 23 publications

Survival Analysis of Cancer Patients in North Eastern Nigeria from 2004 – 2017 – A Kaplan - Meier Method

Survival Analysis of Cancer Patients in North Eastern Nigeria from 2004 – 2017 – A Kaplan - Meier Method

Multicellular Effects of STAT3 in Non-small Cell Lung Cancer: Mechanistic Insights and Therapeutic Opportunities

Nanovaccines: An effective therapeutic approach for cancer therapy

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