Stat3-positive tumor cells contribute to vessels neoformation in primary central nervous system lymphoma

Ruggieri, Simona; Tamma, Roberto; Resta, Nicoletta; Albano, Francesco; Coccaro, Nicoletta; Loconte, Daria Carmela; Annese, Tiziana; Errede, Mariella; Specchia, Giorgina; Senetta, Rebecca; Cassoni, Paola; Ribatti, Doménico

doi:10.18632/oncotarget.16115

Cited by 15 publications

(8 citation statements)

References 76 publications

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“…These data confirm also our previously published data showing that, in primary central nervous system lymphoma, tumor vessels appeared lined by endothelial cells expressing both FVIII and STAT3 signals, while in the control brain tissue, only FVIII-positive vessels were detectable [18]. Endothelial cells lining these vessels are heterogeneous, expressing FVIII and STAT3, and presumably, originally they are vascular progenitor cells.…”

Section: Discussionsupporting

confidence: 91%

STAT-3 RNAscope Determination in Human Diffuse Large B-Cell Lymphoma

Tamma

Ingravallo

Albano

et al. 2019

Translational Oncology

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BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin's lymphoma. Signal transducer and activator of transcription 3 (STAT3) is a cytoplasmic transcription with many important functions, including regulation of cell proliferation, differentiation, survival, angiogenesis, and immune response. MATERIALS AND METHODS: In this study, we have compared by means of RNAscope technology STAT3 RNA expression in human DLBCL in a selected group of activated B-cell–like DLBCL (ABC-DLBCL) patients with another group of germinal center B-cell–like DLBCL (GBC-DLBCL) patients. RESULTS: The results have shown that ABC DLBCL tissue samples contained a significantly higher number of STAT3-positive cells as compared with GCB tissue samples. Moreover, by means of confocal immunofluorescence analysis, we have observed that tumor vessels in ABC samples appeared lined by endothelial cells expressing both FVIII and STAT3 signals, while in GCB samples, only few vessels coexpressed FVIII and STAT3. CONCLUSIONS: These data confirm other reports showing that STAT3 is highly expressed and activated in ABC-DLBCL and our previously published data demonstrating that, in primary central nervous system lymphoma, tumor vessels appeared lined by endothelial cells expressing both FVIII and STAT3.

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Section: Discussionsupporting

confidence: 91%

STAT-3 RNAscope Determination in Human Diffuse Large B-Cell Lymphoma

Tamma

Ingravallo

Albano

et al. 2019

Translational Oncology

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“… 53 – 55 One study showed that even Nestin, a specific marker of neural stem cells, can be used to identify CSCs. 56 These markers can be utilized not only to identify and isolate CSCs but also to predict treatment efficacy in the clinic, shedding light on how CSCs contribute to poor survival and tumor progression. 55 The markers shared between CSCs and normal stem cells imply that there are some similar biological characteristics between them, such as self-renewal and endless proliferation, under the suitable conditions.…”

Section: Tumor Inflammatory Microenvironmentmentioning

confidence: 99%

Tumor-associated macrophage-derived cytokines enhance cancer stem-like characteristics through epithelial–mesenchymal transition

Chen¹,

Tan²,

Wang³

2018

OTT

101

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Cancer stem cells are a small population of cells with the potential for self-renewal and multi-directional differentiation and are an important source of cancer initiation, treatment resistance, and recurrence. Epithelial–mesenchymal transition (EMT) is a process in which epithelial cells lose their epithelial phenotype and convert to mesenchymal cells. Recent studies have shown that cancer cells undergoing EMT can become stem-like cells. Many kinds of tumors are associated with chronic inflammation, which plays a role in tumor progression. Among the various immune cells mediating chronic inflammation, macrophages account for ~30%–50% of the tumor mass. Macrophages are highly infiltrative in the tumor microenvironment and secrete a series of inflammatory factors and cytokines, such as transforming growth factor (TGF)-β, IL-6, IL-10, and tumor necrosis factor (TNF)-α, which promote EMT and enhance the stemness of cancer cells. This review summarizes and discusses recent research findings on some specific mechanisms of tumor-associated macrophage-derived cytokines in EMT and cancer stemness transition, which are emerging targets of cancer treatment.

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“…Studies have reported an association between angiogenesis and prognosis in PCNSL [ 16 , 17 ]. However, the effects of baseline characteristics, genomic profiles, and treatment modalities on overall survival and outcomes of PCNSL have not been studied.…”

Section: Introductionmentioning

confidence: 99%

[Retracted] Effect of Tumor Microenvironment and Angiogenesis on Clinical Outcomes of Primary Central Nervous System Lymphoma

Wang

Hsiao

et al. 2021

BioMed Research International

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Primary central nervous system lymphoma (PCNSL) is a rare lymphoma, and the disease course is often aggressive with poor prognosis outcomes. PCNSL undergoes germinal center reactions and impairs B-cell maturation. However, angiogenesis is also involved in the tumorigenesis and progression of PCNSL. This study investigated the effects of the tumor microenvironment and angiogenesis-associated genomic alterations on the outcomes of PCNSL. The analysis also evaluated the influence of treatment modality and timing on PCNSL survival using partial least squares variance-based path modeling (PLS-PM). PLS-PM can be used to evaluate the complex relationship between prognostic variables and disease outcomes with a small sample of measurements and structural models. A total of 19 immunocompetent PCNSL samples were analyzed by exome sequencing. Our results suggest that the timing of radiotherapy and mutations of ROBO1 and KAT2B are potential indicators of PCNSL outcomes and may be affected by baseline characteristics such as age and sex. Our results also showed that patients with no mutations of ROBO1 and KAT2B, SubRT subgroup showed favorable survival outcomes compared with no SubRT subgroup in short-term follow-up. All SubRT patients have received high-dose methotrexate induction chemotherapy in the initial treatment. Therefore, initial induction chemotherapy combined with subsequent radiotherapy might improve survival outcomes in PCNSL patients who have no ROBO1 and KAT2B somatic mutations in short-term follow-up. The overall findings suggest that the tumor microenvironment and angiogenesis-associated genomic alterations and treatment modalities are potential indicators of overall survival and may be affected by the baseline characteristics of PCNSL patients.

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Stat3-positive tumor cells contribute to vessels neoformation in primary central nervous system lymphoma

Cited by 15 publications

References 76 publications

STAT-3 RNAscope Determination in Human Diffuse Large B-Cell Lymphoma

STAT-3 RNAscope Determination in Human Diffuse Large B-Cell Lymphoma

Tumor-associated macrophage-derived cytokines enhance cancer stem-like characteristics through epithelial–mesenchymal transition

[Retracted] Effect of Tumor Microenvironment and Angiogenesis on Clinical Outcomes of Primary Central Nervous System Lymphoma

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Stat3-positive tumor cells contribute to vessels neoformation in primary central nervous system lymphoma

Cited by 15 publications

References 76 publications

STAT-3 RNAscope Determination in Human Diffuse Large B-Cell Lymphoma

STAT-3 RNAscope Determination in Human Diffuse Large B-Cell Lymphoma

Tumor-associated macrophage-derived cytokines enhance cancer stem-like characteristics through epithelial&ndash;mesenchymal transition

[Retracted] Effect of Tumor Microenvironment and Angiogenesis on Clinical Outcomes of Primary Central Nervous System Lymphoma

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Tumor-associated macrophage-derived cytokines enhance cancer stem-like characteristics through epithelial–mesenchymal transition