“…CCL5 ( RANTES ), CCR5, CD4 , STAT4 , IL10 , and LYZ were significantly upregulated in LDNs, whereas CXCL8 ( IL8 ), STAT1 , IFNAR1 , NFKB1 , TICAM1 , and TNF were significantly downregulated ( Figure 2 ) ( La Manna et al., 2019 ). CCL5 , STAT4 , CD4 , LYZ upregulation in neutrophils have been associated with inflammation and neutrophil antimicrobial activity ( Flanagan and Lionetti, 1955 ; Pan et al., 2000 ; Hartl et al., 2008 ; Keeter et al., 2020 ; Mehrpouya-Bahrami et al., 2021 ). IL-10 and IFNAR1 signaling have been associated with susceptibility to TB and poor outcomes of disease ( Verbon et al., 1999 ; Bonecini-Almeida et al., 2004 ; Jamil et al., 2007 ; Dorhoi et al., 2014 ; Huynh et al., 2018 ; Zhang et al., 2018 ; Moreira-Teixeira et al., 2020 ).…”