“…Addressing this challenge, the Research Domain Criteria (RDoC) project was launched where systems based on cognitive, behavioral and neuronal mechanisms are the focus of investigation rather than a DSM classified psychiatric disorder (Cuthbert, 2015). Relatedly, several suicide studies from our laboratory and others have examined specific symptoms that reflect corresponding disturbances in functional domains, such as anhedonia (Bradley et al, 2015; Fawcett et al, 1990; Gabbay et al, 2015; Kollias et al, 2008; Nock and Kazdin, 2002; Spijker et al, 2010; Winer et al, 2014), anxiety/entrapment (Goldston et al, 1996; Goldston et al, 2006; Hendin et al, 2010; O’Connor et al, 2013; Ohring et al, 1996; Panagioti et al, 2012; Sareen et al, 2005a; Sareen et al, 2005b; Yaseen et al, 2012; Yaseen et al, 2014), and attachment disturbances (Adam et al, 1996; Grunebaum et al, 2010; Lessard and Moretti, 1998; Lizardi et al, 2011; Palitsky et al, 2013). In particular, anhedonia reflects disturbance in reward processing including reward motivation (Auerbach et al, 2015; Gold et al, 2013), attainment (Liu et al, 2016), and learning (Pizzagalli et al, 2008; Pizzagalli et al, 2005); entrapment reflects response to acute threat in the context of frustrative nonreward (Gilbert and Allan, 1998); state and trait anxiety reflect acute sensitivity to and chronic vigilance for threat, respectively (Bishop, 2009; Jusyte et al, 2015); finally, fearful attachment represents disturbance in the social systems involved in affiliation (Safran, 1990; Yaseen et al, 2016).…”