State-Dependent Gain Modulation of Spinal Motor Output

Guggenberger, Robert; Raco, Valerio; Gharabaghi, Alireza

doi:10.3389/fbioe.2020.523866

Cited by 3 publications

(1 citation statement)

References 69 publications

(106 reference statements)

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“…MI results in sensorimotor desynchronization of alpha and beta oscillations ( Fadiga et al, 1999 ; Pfurtscheller et al, 2006 ) and has a top-down influence on cortico-spinal excitability ( Oishi et al, 1994 ; Li et al, 2004 ; Aoyama and Kaneko, 2011 ). Using MI to modulate the sensorimotor brain state, state-dependency of transcranial magnetic stimulation (TMS) and PES has been demonstrated for the motor system ( Kraus et al, 2016a , b , 2018 ; Guggenberger et al, 2018 , 2020 ; Ziegler et al, 2019 ). Stimulation applied concurrently with MI enhanced the modulation of corticospinal excitability, as reflected by an increase of the amplitude of the motor-evoked potential (MEP) ( Saito et al, 2013 ; Kaneko et al, 2014 ; Kraus et al, 2016a , b ).…”

Section: Introductionmentioning

confidence: 99%

Peripheral Electrical Stimulation Modulates Cortical Beta-Band Activity

et al. 2021

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Low-frequency peripheral electrical stimulation using a matrix electrode (PEMS) modulates spinal nociceptive pathways. However, the effects of this intervention on cortical oscillatory activity have not been assessed yet. The aim of this study was to investigate the effects of low-frequency PEMS (4 Hz) on cortical oscillatory activity in different brain states in healthy pain-free participants. In experiment 1, PEMS was compared to sham stimulation. In experiment 2, motor imagery (MI) was used to modulate the sensorimotor brain state. PEMS was applied either during MI-induced oscillatory desynchronization (concurrent PEMS) or after MI (delayed PEMS) in a cross-over design. For both experiments, PEMS was applied on the left forearm and resting-state electroencephalography (EEG) was recording before and after each stimulation condition. Experiment 1 showed a significant decrease of global resting-state beta power after PEMS compared to sham (p = 0.016), with a median change from baseline of −16% for PEMS and −0.54% for sham. A cluster-based permutation test showed a significant difference in resting-state beta power comparing pre- and post-PEMS (p = 0.018) that was most pronounced over bilateral central and left frontal sensors. Experiment 2 did not identify a significant difference in the change from baseline of global EEG power for concurrent PEMS compared to delayed PEMS. Two cluster-based permutation tests suggested that frontal beta power may be increased following both concurrent and delayed PEMS. This study provides novel evidence for supraspinal effects of low-frequency PEMS and an initial indication that the presence of a cognitive task such as MI may influence the effects of PEMS on beta activity. Chronic pain has been associated with changes in beta activity, in particular an increase of beta power in frontal regions. Thus, brain state-dependent PEMS may offer a novel approach to the treatment of chronic pain. However, further studies are warranted to investigate optimal stimulation conditions to achieve a reduction of pain.

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Section: Introductionmentioning

confidence: 99%

Peripheral Electrical Stimulation Modulates Cortical Beta-Band Activity

et al. 2021

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Evidence That Brain-Controlled Functional Electrical Stimulation Could Elicit Targeted Corticospinal Facilitation of Hand Muscles in Healthy Young Adults

Suzuki

Jovanovic

Fadli

et al. 2023

Neuromodulation: Technology at the Neural Interface

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Using mechanistic knowledge to appraise contemporary approaches to the rehabilitation of upper limb function following stroke

Carson,

Hayward

2024

The Journal of Physiology

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It is a paradox of neurological rehabilitation that, in an era in which preclinical models have produced significant advances in our mechanistic understanding of neural plasticity, there is inadequate support for many therapies recommended for use in clinical practice. When the goal is to estimate the probability that a specific form of therapy will have a positive clinical effect, the integration of mechanistic knowledge (concerning ‘the structure or way of working of the parts in a natural system’) may improve the quality of inference. This is illustrated by analysis of three contemporary approaches to the rehabilitation of lateralized dysfunction affecting people living with stroke: constraint‐induced movement therapy; mental practice; and mirror therapy. Damage to ‘cross‐road’ regions of the structural (white matter) brain connectome generates deficits that span multiple domains (motor, language, attention and verbal/spatial memory). The structural integrity of these regions determines not only the initial functional status, but also the response to therapy. As structural disconnection constrains the recovery of functional capability, ‘disconnectome’ modelling provides a basis for personalized prognosis and precision rehabilitation. It is now feasible to refer a lesion delineated using a standard clinical scan to a (dis)connectivity atlas derived from the brains of other stroke survivors. As the individual disconnection pattern thus obtained suggests the functional domains most likely be compromised, a therapeutic regimen can be tailored accordingly. Stroke is a complex disorder that burdens individuals with distinct constellations of brain damage. Mechanistic knowledge is indispensable when seeking to ameliorate the behavioural impairments to which such damage gives rise. image

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State-Dependent Gain Modulation of Spinal Motor Output

Cited by 3 publications

References 69 publications

Peripheral Electrical Stimulation Modulates Cortical Beta-Band Activity

Peripheral Electrical Stimulation Modulates Cortical Beta-Band Activity

Evidence That Brain-Controlled Functional Electrical Stimulation Could Elicit Targeted Corticospinal Facilitation of Hand Muscles in Healthy Young Adults

Using mechanistic knowledge to appraise contemporary approaches to the rehabilitation of upper limb function following stroke

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