State-Dependent Respiratory and Cardiac Relationships with Neuronal Discharge in the Bed Nucleus of the Stria Terminalis

Terreberry, R. R.; Oguri, Mitsugu; Harper, Ronald M.

doi:10.1093/sleep/18.3.139

Cited by 13 publications

(9 citation statements)

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“…The BNST sends fibers to respiratory phaseswitching areas of the medial parabrachial area and to the solitary tract, dorsal vagus, and ambiguus nuclei (Holstege et al, 1985), and receives projections from those sites. BNST neurons also show sleep state-specific respi- ratory and cardiac-related discharge (Terreberry et al, 1995). The BNST injury may contribute to the loss of negative affect associated with respiratory stimuli in CCHS patients.…”

Section: Cingulate Cortex and Cingulum Bundlementioning

confidence: 96%

Neuroanatomic deficits in congenital central hypoventilation syndrome

Kumar

Macey

Woo

et al. 2005

J of Comparative Neurology

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100

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Congenital Central Hypoventilation Syndrome (CCHS) patients exhibit compromised autonomic regulation, reduced breathing drive during sleep, diminished ventilatory responses to chemoreceptor stimulation, and diminished air hunger perception. The syndrome provides an opportunity to partition neural processes regulating breathing and cardiovascular action. No obvious lesions appear with conventional magnetic resonance imaging; however, T2 relaxometry procedures can detect reduced cell or fiber density or diminished myelination not found with routine evaluation. High-resolution T1, proton density, and T2-weighted brain images were collected from 12 patients and 28 age- and gender-matched controls. Voxel-by-voxel T2 maps were generated from the proton density and T2-weighted images and evaluated by voxel-based-relaxometry procedures. Normalized and smoothed T2 maps were compared between groups using analysis of covariance at each voxel, with age and ventricle size included as covariates. Patients showed damaged or maldeveloped tissue, principally right-sided, including white matter from the level of the anterior cingulate cortex caudally to the level of the posterior cingulate and laterally to the posterior superior temporal cortex. Portions of the posterior, mid, and anterior cingulate, as well as the internal capsule, putamen, and globus pallidus and basal forebrain extending to the anterior and medial thalamus were affected. Deficits in the cingulum bundle and mid-hippocampus and ventral prefrontal cortex appeared, as well as the right cerebellar cortex and deep nuclei. Neuroanatomic deficiencies in limbic structures suggest a structural basis for reduced air hunger perception, thermoregulatory and autonomic deficiencies in the syndrome, while cerebellar deficits may also contribute to breathing and cardiovascular dysregulation.

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Section: Cingulate Cortex and Cingulum Bundlementioning

confidence: 96%

Neuroanatomic deficits in congenital central hypoventilation syndrome

Kumar

Macey

Woo

et al. 2005

J of Comparative Neurology

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100

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“…17,20,21 Consistent with these projections, the lateral BNST is importantly involved in such autonomic processes as cardiovascular and respiratory function. 22‐25 Withdrawal from opiate drugs is associated with profound changes in neuroendocrine, autonomic, aversive and stress‐related systems; therefore it seems quite possible that alterations in BNST activity contribute to opiate‐withdrawal behaviors. Moreover, the BNST receives one of the densest NE fiber inputs in the brain.…”

Section: Introductionmentioning

confidence: 99%

The Bed Nucleus of the Stria Terminalis: A Target Site for Noradrenergic Actions in Opiate Withdrawal

Aston‐Jones

Delfs

Druhan

et al. 1999

Annals of the New York Academy of Sciences

227

196

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Hyperactivity of brain norepinephrine (NE) systems has long been implicated in mechanisms of opiate withdrawal (OW). However, little is known about where elevated NE may act to promote OW. Here we report that the bed nucleus of the stria terminalis (BNST), the densest NE target in the brain, is critical for NE actions in OW. (1) Many BNST neurons become Fos+ after OW. Pretreatment with the beta antagonist, propranolol, markedly reduces OW symptoms and the number of Fos+ cells in the BNST. (2) Numerous neurons in the nucleus tractus solitarius (A2 neurons) and the A1 cell group are triple labeled for tyrosine hydroxylase, a retrograde tracer from the BNST, and Fos after OW, revealing numerous NE neurons that project to the BNST from the medulla that are stimulated by OW. Fewer such triple-labeled neurons were found in the locus caeruleus. (3) Behavioral studies reveal that local microinjections of selective beta-adrenergic antagonists into the BNST attenuate OW symptoms. In particular, withdrawal-induced place aversion is abolished by bilateral microinjection of a cocktail of selective beta 1 (betaxolol) plus the beta 2 (ICI 181,555) antagonists (1.0 nmol each/0.5 microL per side) into the BNST. Similar results were obtained with neurochemically selective lesions of the ventral ascending NE bundle, the pathway for A1 and A2 projections to the BNST. Similar lesions of the dorsal NE bundle of projections from the locus caeruleus had no effect on either aversive or somatic withdrawal symptoms. Together, these results indicate that beta-receptor activation in the BNST is critical for aversive withdrawal symptoms, and that A1 and A2 neurons in the medulla are the source of this critical NE.

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“…To test whether this manipulation modulated physiological manifestations of anxiety, we stimulated BNST somata while monitoring respiratory rate; hyperventilation is linked to increased anxiety in humans 15,16 and rodents (Supplementary Fig. 7), and the BNST is known to project to respiratory centres 17,18 . Indeed, increased respiratory rate was observed (Supplementary Fig.…”

mentioning

confidence: 99%

Diverging neural pathways assemble a behavioural state from separable features in anxiety

Kim

Adhikari

Lee

et al. 2013

Nature

566

644

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Behavioural states in mammals, such as the anxious state, are characterized by several features that are coordinately regulated by diverse nervous system outputs, ranging from behavioural choice patterns to changes in physiology (in anxiety, exemplified respectively by risk-avoidance and respiratory rate alterations). Here we investigate if and how defined neural projections arising from a single coordinating brain region in mice could mediate diverse features of anxiety. Integrating behavioural assays, in vivo and in vitro electrophysiology, respiratory physiology and optogenetics, we identify a surprising new role for the bed nucleus of the stria terminalis (BNST) in the coordinated modulation of diverse anxiety features. First, two BNST subregions were unexpectedly found to exert opposite effects on the anxious state: oval BNST activity promoted several independent anxious state features, whereas anterodorsal BNST-associated activity exerted anxiolytic influence for the same features. Notably, we found that three distinct anterodorsal BNST efferent projections-to the lateral hypothalamus, parabrachial nucleus and ventral tegmental area-each implemented an independent feature of anxiolysis: reduced risk-avoidance, reduced respiratory rate, and increased positive valence, respectively. Furthermore, selective inhibition of corresponding circuit elements in freely moving mice showed opposing behavioural effects compared with excitation, and in vivo recordings during free behaviour showed native spiking patterns in anterodorsal BNST neurons that differentiated safe and anxiogenic environments. These results demonstrate that distinct BNST subregions exert opposite effects in modulating anxiety, establish separable anxiolytic roles for different anterodorsal BNST projections, and illustrate circuit mechanisms underlying selection of features for the assembly of the anxious state.

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State-Dependent Respiratory and Cardiac Relationships with Neuronal Discharge in the Bed Nucleus of the Stria Terminalis

Cited by 13 publications

References 0 publications

Neuroanatomic deficits in congenital central hypoventilation syndrome

Neuroanatomic deficits in congenital central hypoventilation syndrome

The Bed Nucleus of the Stria Terminalis: A Target Site for Noradrenergic Actions in Opiate Withdrawal

Diverging neural pathways assemble a behavioural state from separable features in anxiety

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