State estimation and error diagnosis in industrial fed‐batch yeast fermentation

On-line evolutionary optimization of an industrial fed-batch yeast fermentation process

“…The fermentor with a 25 m 3 volume, is equipped with external half coils for cooling. The airflow rate is measured by a vortex flowmeter (EMCO, V-Bar 700) and molasses and ammonia flow rates are measured by electromagnetic flow meters (Krohne, IFM 090) [33]. Biomass concentration is not measured on-line, therefore it is determined by analyses in laboratory.…”

Nonlinear control of large-scale fed-batch yeast fermentation: control of the specific growth rate

“…The details of estimation of biomass concentration and specific growth rates can be found in the work of Hocalar et al [28]. The estimated biomass concentrations were then applied to the control model in order to produce an appropriate controller law.…”

“…The derivation of balanced/reconciliated conversion rates is performed in every programming cycle (15 min). Finally, more accurate biomass concentration values are obtained by using the reconciliated/balanced conversion rates [28]. The specific growth rate is calculated from the moving average of successive biomass estimations.…”

Comparison of different estimation techniques for biomass concentration in large scale yeast fermentation

“…These methods are used in different model based state estimation and control studies individually in our group at different times [17,[33][34][35][36]. The proposed methods are: (1) estimation based on kinetic model of overflow metabolism; (2) metabolic black-box model based estimation; (3) asymptotic observer based estimation; (4) artificial neural network based estimation and (5) differential evolution based estimation.…”