State of aggregation and toxicity of aqueous fullerene solutions

Kyzyma, O. A.; Авдеев, М. В.; Bolshakova, O. I.; Melentev, Pavel; Саранцева, С. В.; Ivankov, Oleksandr I.; Korobov, M.V.; Mikheev, Ivan V.; Тропин, Т. В.; Kubovčíková, Martina; Kopčanský, P.; Korolovych, Volodymyr F.; Аксенов, В. Л.; Bulavin, L. A.

doi:10.1016/j.apsusc.2019.03.167

Cited by 32 publications

(20 citation statements)

References 41 publications

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“…Furthermore, at a certain cluster size, lipid bilayer loses its ability to dissolve fullerene [48]. However, Kyzyma et al [67] did viability tests using living cell cultures and found that the fullerene aggregate size in water appears not to be a key factor for toxicity.…”

Section: Discussionmentioning

confidence: 99%

Formation of aggregates, icosahedral structures and percolation clusters of fullerenes in lipids bilayers: The key role of lipid saturation

Nisoh¹,

Jarerattanachat²,

Karttunen³

et al. 2020

Biochimica et Biophysica Acta (BBA) - Biomembranes

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Carbon nanoparticles (CNPs) are attractive materials for a great number of applications but there are serious concerns regarding their influence on health and environment. Here, our focus is on the behavior of fullerenes in lipid bilayers with varying lipid saturations, chain lengths and fullerene concentrations using coarse-grained molecular dynamics (CG-MD) simulations. Our findings show that the lipid saturation level is a key factor in determining how fullerenes behave and where the fullerenes are located inside a lipid bilayer. In saturated and monounsaturated bilayers fullerenes aggregated and formed clusters with some of them showing icosahedral structures . In polyunsaturated lipid bilayers, no such structures were observed: In polyunsaturated lipid bilayers at high fullerene concentrations, connected percolation-like networks of fullerenes spanning the whole lateral area emerged at the bilayer center. In other systems only separate isolated aggregates were observed. The effects of fullerenes on lipid bilayers depend strongly on fullerene aggregation. When fullerenes aggregate, their interactions with the lipid tails change..

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Section: Discussionmentioning

confidence: 99%

Formation of aggregates, icosahedral structures and percolation clusters of fullerenes in lipids bilayers: The key role of lipid saturation

Nisoh¹,

Jarerattanachat²,

Karttunen³

et al. 2020

Biochimica et Biophysica Acta (BBA) - Biomembranes

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show abstract

“…Similar structural and important biophysical investigations take place [59][60][61]. The connection with other fullerene solutions is emphasized, for example, in [53,62], due to the applicability of C 60 /C 70 solutions in NMP for the transition to aqueous fullerene dispersions.…”

Section: Resultsmentioning

confidence: 71%

Investigations of the Kinetics of Cluster Growth in Fullerene C60 Solutions

et al. 2020

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Fullerenes tend to form clusters in different solutions. In this work, a brief survey and some results in the field of investigations of the structure and kinetics of clusters growing in C60 solutions are presented. The general character of this phenomenon for fullerenes is emphasized, and the considerations of mechanisms responsible for the formation and growth of clusters are discussed. We distinguish different types of fullerene solvents by the aggregation mechanism. The kinetics of cluster growth measured via the dynamic light scattering is presented. The complicated structure of clusters in different solutions is briefly discussed.

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“…The optimum fullerene concentrations, ratio of the aqueous and organic phase with dissolved fullerene, and the time of ultrasonic treatment have already been determined for C 60 , C 70 [43] , [44] and Y@C 82 [45] . In this work, we projected our previously obtained data on the ultrasound-bath-assisted solvent-exchange process [43] , [44] , [45] , [46] onto an immersed ultrasound probe. On the other hand, an ultrasound probe was previously used for the preparation of fullerene derivatives only [25] , [47] .…”

Section: Resultsmentioning

confidence: 99%