State of Brain Networks in Long COVID: Post Mild to Moderate Acute COVID-19 Disease

Kapoor, Akshay; Mahajan, Goldaa; Kapur, Aprajita

doi:10.2139/ssrn.4309672

Cited by 3 publications

(3 citation statements)

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“…7 There is research showing alterations in default mode network connectivity in patients with Long-COVID symptoms. 8 Other research has pointed to the effects of psychedelics on gene expression as a means of influencing synaptic plasticity and neural inflammation as well as decreasing acute phase reactants, which could underlie the sustained benefits seen in studies of depression and other chronic neuropathic conditions. 9…”

Section: Discussionmentioning

confidence: 99%

Long-COVID Symptoms Improved after MDMA and Psilocybin Therapy: a case report

Chopra,

Furnish,

Verduzco-Gutierrez

et al. 2024

Preprint

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Section: Discussionmentioning

confidence: 99%

Long-COVID Symptoms Improved after MDMA and Psilocybin Therapy: a case report

Chopra,

Furnish,

Verduzco-Gutierrez

et al. 2024

Preprint

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“…It has been hypothesized that the ability of psychedelics to alter DMN connectivity infers benefit in chronic neuropathic conditions by improving efficiency of these networks 7 . There is research showing alterations in default mode network connectivity in patients with Long‐COVID symptoms 8 . Other research has pointed to the effects of psychedelics on gene expression as a means of influencing synaptic plasticity and neural inflammation as well as decreasing acute phase reactants, which could underlie the sustained benefits seen in studies of depression and other chronic neuropathic conditions 9 …”

Section: Discussionmentioning

confidence: 99%

Long‐COVID symptoms improved after MDMA and psilocybin therapy: A case report

Chopra,

Furnish,

Verduzco‐Gutierrez

et al. 2024

Clinical Case Reports

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Key Clinical MessageLong‐COVID syndrome lacks effective holistic treatment options. We present a case of a 41‐year‐old fully vaccinated female with Long‐COVID syndrome who obtained significant symptomatic relief after self‐medicating with psilocybin and MDMA.AbstractLong‐COVID, a syndrome persisting after the acute phase of coronavirus disease 2019 (COVID‐19), lacks effective holistic treatment options. We present a case of a 41‐year‐old fully vaccinated female with Long‐COVID syndrome who obtained significant symptomatic relief by self‐prescribing psilocybin and MDMA. Future research is needed to assess safety and efficacy.

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“…Covid-19 pandemic has ended but there are 25-70% of recovered acute Covid-19 patients who continue to remain symptomatic mainly due to neurological manifestations of ongoing inflammation and from the persistent activation of stress mechanisms of the body. Studies have been done by Dayas, et al [3], Kloe, et al [4], Fenoglio, et al [5] and Herman, et al [6] using PET and have shown patterns of brain involvement in PACS patients along with functional studies Kapoor, et al [7] to elicit the dysfunctional connectivity of brain networks however no study has been done so far to show the neurobiology of stress in such patients. The author studied 50 patients with functional neurological manifestations at one year of recovered post covid-19 disease (PACS) at one year using rs-fMRI.…”

Section: Introductionmentioning

confidence: 99%

Imaging Phenotypes of Stress Based on Functional MRI

Kapoor¹

2023

J Clin Med Res.

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Background: Stress is an adaptive response to daily challenges faced by the body to maintain its internal homeostasis. The pathophysiology of stress has been described based on the role of the sympatho-adrenergic system and the hypothalamic-pituitary- adrenal axis. Few studies have been done describing the role of functional MRI and PET to study the patterns of brain involvement in symptomatic patients. Methods: The author studied 50 post-acute covid-19 syndrome patients one year after the acute episodes along with 10 healthy control patients. Based on the patterns of stress on imaging the patients were phenotyped on the severity of the changes of stress into a classification system. Results: The results of the study showed a distinct temporal pattern of changes based on the severity of chronic stress. Class II and III Group patients on imaging formed the largest number 32(64%) and also showed good correlation with PCS-10 scores which were moderate in this group. The supra optic nucleus followed by para ventricular nuclei were the commonest affected during stress. The study showed that involvement of DMN and SALIEN was seen as the severity of stress progressed to a burn out stage IV which resulted in hypoactivation of all major networks and hypothalamic nuclei. Hippocampal and amygdala volumetric changes alongwith altered asymmetry was seen in class II-IV groups. Conclusion: The author concluded that functional MRI could detect the pattern of changes of stress and the findings not only can be helpful in the diagnosis but also in planning management of these patients.

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State of Brain Networks in Long COVID: Post Mild to Moderate Acute COVID-19 Disease

Cited by 3 publications

References 0 publications

Long-COVID Symptoms Improved after MDMA and Psilocybin Therapy: a case report

Long-COVID Symptoms Improved after MDMA and Psilocybin Therapy: a case report

Long‐COVID symptoms improved after MDMA and psilocybin therapy: A case report

Imaging Phenotypes of Stress Based on Functional MRI

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