This review aimed to summarize determinants influencing clinician's antibiotic prescribing behaviors in Bangladesh. The 18 published articles and grey literature were selected from scientific databases of Web of Science, Global Health, Medline, Pub Med, the Lancet, Cochrane Library and websites of some health organizations and Bangladesh Ministry of Health. A conceptual framework COMB model was utilized to identify and analyze determinants influencing antibiotics prescribing behaviors. The findings of the review revealed that there is a considerable gap in individual-level knowledge, skills, and awareness to rational antibiotic prescribing among physicians. Lack of training, no provision of prescription auditing, and patient load are key barriers to standard antibiotic prescribing practices. The patient's ignorance and expectation of antibiotics, antibiotics promotion with misleading information and financial incentives by pharmaceutical companies potentially motivate prescribers' decision to prescribe even expensive and unnecessary antibiotics. Moreover, lack of adoption and implementation of regulatory policies intensify poor antibiotic prescribing attitude in Bangladesh. Determinants to APB are multiple, multileveled and multi-complexes. There is no alternative without developing pragmatic interventions (educational and regulatory) targeted to key barriers improving APB at healthcare level in Bangladesh. It is recommended to key stakeholders, academia, and key implementers; DGHS, DGDA, and MOHFW of the country in adopting a national action plan to control imprudent antibiotic prescribing behaviors by clinicians and implementing interventions from local to national level at healthcare institutions with an urgent policy action-key to tackle antibiotic resistance in future.