Power plant projects, like ARIES, present an essential element of the US fusion developmental process in order to provide a perspective on potential fusion concepts and understand future trends. The nuclear assessment has been a fundamental element of the ARIES project since its inception in the early 1990s. Over the years, we performed state-of-the-art assessments to understand the rational basis for the damaging/enhancing changes to the tritium breeding of several design elements. Equally important, we developed a new scheme to control the tritium breeding online, novel approaches to deliver well-optimized shields for various fusion concepts, and a new strategy to handle the continuous stream of radioactive materials and minimize the radwaste burden for future generations. The collective impact of such innovations has done much to shape the design development of the various ARIES concepts over the past 20 years.