The popularity of wireless communication accelerates research on new technologies that are required to satisfy users' needs. Wireless mesh networks (WMNs), which are additional access technologies instead of being a renewed one, have an important place among next-generation wireless networks. In particular, the capability of working without any infrastructure is the most outstanding advantage of WMNs. There are many studies aimed at WMNs, particularly channel assignment and routing methods for multichannel multiradio structures that provide higher data capacity. Interference, which has a direct effect on the quality of communication, is still a challenge to be addressed. In this study, multichannel multiradio WMNs and various channel assignment schemes are analyzed. Directional mesh (DMesh) architecture, which uses directional antennas to form a multichannel structure, is analyzed in terms of channel assignment procedure. A new interference-aware channel assignment scheme that aims to eliminate DMesh's disadvantages is proposed and performances of both schemes are compared. Several results of experimental analysis prove that the proposed channel assignment scheme improves the performance of DMesh.