State of the Art Imaging of Osteoporosis

Chen, Michelle; Gerges, Maria; Raynor, William Y.; Park, Peter Sang Uk; Nguyen, Edward; Chan, David H.; Gholamrezanezhad, Ali

doi:10.1053/j.semnuclmed.2023.10.008

Cited by 7 publications

(2 citation statements)

References 117 publications

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“…Despite the WHO definition and therapeutic decision for osteoporosis still relying on the gold standard DXA results, the use of opportunistic CT as a screening tool identifying undiagnosed patients at high risk of fractures is without any doubt a tool that should be increasingly implemented in common practice, and may also replace the DXA in case the latter is 810 not feasible. [17][18][19] In this study, the average age of the patients was 59.02 years, and most of the patients used chest CT plain scans for COPD and lung cancer screening. Since the age of chest CT was close to the age of the high-risk patients of osteoporosis, and the parameters of chest CT were relatively fixed, the influence of voltage on attenuation value was avoided, making it likely to become the most economical and safe method for osteoporosis screening in the future.…”

Section: Discussionmentioning

confidence: 99%

The Suitable Population for Opportunistic Low Bone Mineral Density Screening Using Computed Tomography

Zhang,

Luo,

Zhou

et al. 2024

CIA

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Objective To explore the suitable population of CT value for predicting low bone mineral density (low-BMD). Methods A total of 1268 patients who underwent chest CT examination and DXA within one-month period retrospectively analyzed. The CT attenuation values of trabecular bone were measured in mid-sagittal plane from thoracic vertebra 7 (T7). Receiver operating characteristic (ROC) curves were used to evaluate the ability to diagnose low-BMD. Results The AUC for diagnosing low BMD was larger in women than in men (0.894 vs 0.744, p < 0.05). The AUC increased gradually with the increase of age but decreased gradually with the increase in height and weight (p < 0.05). In females, when specificity was adjusted to approximately 90%, a threshold of 140.25 HU has a sensitivity of 69.3%, which is higher than the sensitivity of 36.5% in males for distinguishing low-BMD from normal. At the age of 70 or more, when specificity was adjusted to approximately 90%, a threshold of 126.31 HU has a sensitivity of 76.1%, which was higher than that of other age groups. Conclusion For patients who had completed chest CTs, the CT values were more effective in predicting low-BMD in female, elderly, lower height, and lower weight patients.

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Section: Discussionmentioning

confidence: 99%

The Suitable Population for Opportunistic Low Bone Mineral Density Screening Using Computed Tomography

Zhang,

Luo,

Zhou

et al. 2024

CIA

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“…Health skeletal is a prominent component of the musculoskeletal system in humans and animals, and its function is to support the body and provide energy for muscle attachment and movement (Buckwalter et al 1996). Bone mineral density (BMD) is a signi cant biological indicator of the quality of bone health (Chen et al 2023). However, BMD values vary at different life stages (Medina et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Causal association between cathepsins and bone mineral density : univariate and multivariate Mendelian randomization analyses

zhang,

Yang,

et al. 2024

Preprint

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Background: Bone mineral density (BMD) is one of the criteria for assessing osteoporosis, and the mechanisms of its change are complex. However, cathepsins can intervene in the onset and progression of osteoporosis. Previous researchers have found an association between cathepsin K and BMD in middle-aged and older people. However, the association between the cathepsin family and other lifecycle BMD remains uncertain. Method: We first performed univariateMendelian randomisation (MR) analysis to explore potential the association between eight cathepsins and five lifecycle BMD. Next, reverse MR was used to analyze the causality between five lifecycle BMD and each cathepsin. Finally, we used multivariate MR to analyze potential associationbetween multiple cathepsins and five lifecycle BMD. Analysis method uses inverse variance weighting (IVW) to assess causal associations. The weighted median method (WME) and MR-Egger regression were taken as the supplementary note. In addition, sensitivity analyses were performed to assess the reliability of this result. Result: The results of IVW by univariate MR analysis showed that histone enzyme Z was a unfavourable protein for BMD in people aged 60 over years of age (IVW: OR=0.95, 95%Cl=0.92-0.99, P=0.03). In people aged 45-60 years, cathepsin H was a risk protein for BMD (IVW: OR =0.97, 95%Cl =0.94-0.99, P=0.04). The remaining cathepsins showed no associations associated with BMD at different life stages. The IVW results of multivariate MR analysis showed that after adjusting for other cathepsins, cathepsin Z was still negatively correlated with BMD in people aged 60 over years (IVW: OR=0.96, 95%Cl=0.92-1.00, P=0.01). Cathepsin H had no correlated with BMD in people aged 45-60 years (IVW: OR=0.97, 95%Cl=0.93-1.00, P=0.06). The results of IVW in the reverse MR analysis showed no association between cathepsins and BMD at different life stages. The results of the sensitivity analyses of the three analytical methods described above indicate the existence of a robust causal relationship. Conclusions: High content of histone enzyme Z may increase the risk of osteoporosis and fractures in people over the age of 60. This finding may not only improve the accuracy of BMD and cathepsin K in predicting and screening for osteoporosis, but may also provide a potential new avenue for effective treatment of osteoporosis.

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Multimodal positron emission tomography (PET) imaging in non-oncologic musculoskeletal radiology

Kogan,

Yoon,

Teeter

et al. 2024

Skeletal Radiol

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State of the Art Imaging of Osteoporosis

Cited by 7 publications

References 117 publications

The Suitable Population for Opportunistic Low Bone Mineral Density Screening Using Computed Tomography

The Suitable Population for Opportunistic Low Bone Mineral Density Screening Using Computed Tomography

Causal association between cathepsins and bone mineral density : univariate and multivariate Mendelian randomization analyses

Multimodal positron emission tomography (PET) imaging in non-oncologic musculoskeletal radiology

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