State of the art in nonthermal plasma processing for biomedical applications: Can it help fight viral pandemics like COVID‐19?

Misra, Nilanjal; Bhatt, Sudhir; Arefi‐Khonsari, Farzaneh; Kumar, Virendra

doi:10.1002/ppap.202000215

Cited by 21 publications

(21 citation statements)

References 185 publications

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“…[7] Plasma technology is being investigated as a novel method to fabricate wound healing materials such as plant secondary metabolites (PSMs), which have been reported to have antibacterial properties. [8][9][10][11][12][13][14] The antibacterial properties of PSMs are believed to result from incorporated monoterpenes inhibiting ATP generation, blocking ion transport, and disrupting cytoplasmic membranes of bacteria. [15][16][17][18] One approach to coating PSMs on wound dressings is the use of radiofrequency plasma-enhanced chemical vapor deposition (RF-PECVD).…”

Section: Introductionmentioning

confidence: 99%

Plasma polymers from oregano secondary metabolites: Antibacterial and biocompatible plant‐based polymers

Romo-Rico

Krishna

Golledge

et al. 2022

Plasma Processes & Polymers

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Bacterial infection of chronic wounds is a major healthcare problem that affects the quality of life of millions of patients worldwide and leads to a substantial healthcare cost burden. This project focused on the manufacture of a potential wound healing agent. Plasma polymers from oregano secondary metabolites (PP-OSMs) were fabricated by radiofrequency plasma-enhanced chemical vapor deposition (RF-PECVD) in continuous and pulse plasma modes at room temperature. The surface, biocompatibility, and antibacterial properties of the PP-OSMs were investigated. Polymers fabricated by RF-PECVD retained the functional groups of OSMs, promoted human dermal fibroblast adhesion, inhibited Staphylococcus aureus attachment, and eliminated Pseudomonas aeruginosa. The PP-OSM coatings are potential candidates for use in medical applications where cell biocompatibility and antibacterial properties are required.

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Section: Introductionmentioning

confidence: 99%

Plasma polymers from oregano secondary metabolites: Antibacterial and biocompatible plant‐based polymers

Romo-Rico

Krishna

Golledge

et al. 2022

Plasma Processes & Polymers

View full text Add to dashboard Cite

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“…Magnetic nanoparticles and quantum dots are the nanoparticles that are commonly employed to detect coronavirus. The protein corona sensor array technology, which would aid in identifying protein/biomolecule sequences at an early stage, is at the forefront of catastrophic COVID-19 (Misra et al 2021 ). The design and implementation of nanotechnology facilitate the production of new nanovaccines with a higher efficacy.…”

Section: Introductionmentioning

confidence: 99%

Superior possibilities and upcoming horizons for nanoscience in COVID-19: noteworthy approach for effective diagnostics and management of SARS-CoV-2 outbreak

Bhattacharjee¹,

Ikbal

Farooqui

et al. 2023

Chem. Pap.

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The outbreak of COVID-19 has caused great havoc and affected many parts of the world. It has imposed a great challenge to the medical and health fraternity with its ability to continue mutating and increasing the transmission rate. Some challenges include the availability of current knowledge of active drugs against the virus, mode of delivery of the medicaments, its diagnosis, which are relatively limited and do not suffice for further prognosis. One recently developed drug delivery system called nanoparticles is currently being utilized in combating COVID-19. This article highlights the existing methods for diagnosis of COVID-19 such as computed tomography scan, reverse transcription-polymerase chain reaction, nucleic acid sequencing, immunoassay, point-of-care test, detection from breath, nanotechnology-based bio-sensors, viral antigen detection, microfluidic device, magnetic nanosensor, magnetic resonance platform and internet-of-things biosensors. The latest detection strategy based on nanotechnology, biosensor, is said to produce satisfactory results in recognizing SARS-CoV-2 virus. It also highlights the successes in the research and development of COVID-19 treatments and vaccines that are already in use. In addition, there are a number of nanovaccines and nanomedicines currently in clinical trials that have the potential to target COVID-19.

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“…Indeed, at present, a large volume of polypropylene facemasks (that should be considered a biohazard) are disposed of every day, while they are not capable of stopping the spreading of the virus. At the same time, the scientific community has already started looking for materials for facemasks with a high degree of protection, as summarized in several works [3,18,[27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Nanohybrid Materials as Candidates for Self-Sanitizing Filters Aimed at Protection from SARS-CoV-2 in Public Areas

et al. 2022

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The COVID-19 pandemic has raised the problem of efficient, low-cost materials enabling the effective protection of people from viruses transmitted through the air or via surfaces. Nanofibers can be a great candidate for efficient air filtration due to their structure, although they cannot protect from viruses. In this work, we prepared a wide range of nanofibrous biodegradable samples containing Ag (up to 0.6 at.%) and Cu (up to 20.4 at.%) exhibiting various wettability. By adjusting the magnetron current (0.3 A) and implanter voltage (5 kV), the deposition of TiO2 and Ag+ implantation into PCL/PEO nanofibers was optimized in order to achieve implantation of Ag+ without damaging the nanofibrous structure of the PCL/PEO. The optimal conditions to implant silver were achieved for the PCL-Ti0.3-Ag-5kV sample. The coating of PCL nanofibers by a Cu layer was successfully realized by magnetron sputtering. The antiviral activity evaluated by widely used methodology involving the cultivation of VeroE6 cells was the highest for PCL-Cu and PCL-COOH, where the VeroE6 viability was 73.1 and 68.1%, respectively, which is significantly higher compared to SARS-CoV-2 samples without self-sanitizing (42.8%). Interestingly, the samples with implanted silver and TiO2 exhibited no antiviral effect. This difference between Cu and Ag containing nanofibers might be related to the different concentrations of ions released from the samples: 80 μg/L/day for Cu2+ versus 15 µg/L/day for Ag+. The high antiviral activity of PCL-Cu opens up an exciting opportunity to prepare low-cost self-sanitizing surfaces for anti-SARS-CoV-2 protection and can be essential for air filtration application and facemasks. The rough cost estimation for the production of a biodegradable nanohybrid PCL-Cu facemask revealed ~$0.28/piece, and the business case for the production of these facemasks would be highly positive, with an Internal Rate of Return of 34%.

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State of the art in nonthermal plasma processing for biomedical applications: Can it help fight viral pandemics like COVID‐19?

Cited by 21 publications

References 185 publications

Plasma polymers from oregano secondary metabolites: Antibacterial and biocompatible plant‐based polymers

Plasma polymers from oregano secondary metabolites: Antibacterial and biocompatible plant‐based polymers

Superior possibilities and upcoming horizons for nanoscience in COVID-19: noteworthy approach for effective diagnostics and management of SARS-CoV-2 outbreak

Biodegradable Nanohybrid Materials as Candidates for Self-Sanitizing Filters Aimed at Protection from SARS-CoV-2 in Public Areas

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