State of the Art in Fertility Preservation for Female Patients Prior to Oncologic Therapies

Chibelean, C.; Petca, R.; Radu, Dan Cristian; Petca, Aida

doi:10.3390/medicina56020089

Cited by 5 publications

(3 citation statements)

References 82 publications

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“…In the context of onco-fertility, the provision of information should be combined with 'appropriate and effective fertility-related' psychological support (fertility counselling) [27]. Nevertheless, onco-fertility counselling is 'under-utilized' for female patients for various reasons [3,11,25,29,[33][34][35]. Indeed, 'only a small part of young cancer patients received fertility preservation services' [11].…”

Section: Discussionmentioning

confidence: 99%

Perceptions and experiences of fertility preservation in Greek female cancer patients

Taniskidou

Voultsos

Tarlatzis

et al. 2023

Preprint

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Background As advances in oncology have led to remarkable and steady improvements in the survival rates of cancer patients and anticancer treatment can cause premature ovarian failure in women, fertility preservation has become a global public health concern and an integral part of the care for women diagnosed with cancer during reproductive age. However, for various reasons, fertility preservation remains underutilized for cancer patients. There are substantial gaps in our knowledge about women’s experience and perceptions on the issue. This study aims to contribute to bridging that gap. Methods This prospective qualitative study was conducted from March 2018 to February 2023. A combination of purposive and snowball sampling was used. Data were collected by semi-structured interviews with nineteen reproductive-age women with a recent cancer diagnosis. Data were classified and analyzed by a thematic analysis approach. Results A variety of distinct themes and subthemes emerged from the analysis of the interview data. The cancer diagnosis emerged as a factor that considerably affects the women’s attitudes towards biological parenthood: It can further increase their (strong) previous desire or decrease their previous (weak) desire. Women with a recent cancer diagnosis did not receive adequate and multidisciplinary counselling, including clear and sufficient information. However, participants felt satisfied from the information they received because they either received the information they requested or remained in denial to get informed (i.e. because they felt overwhelmed after the cancer diagnosis). Embryo cryopreservation emerged as a less desirable fertility preservation option for women with cancer. Participants showed respect for human embryos, not always for religious reasons. Surrogacy emerged as the last resort for most participants. Religious, social or financial factors did play a secondary (if any) role in women’s decision making about fertility preservation. Finally, male partners’ opinions played a secondary role in most participants’ decision-making about fertility preservation. If embryo cryopreservation was the selected option, partners would have a say because they were involved with their genetic material. Conclusions The findings that emerged from data analysis were partly consistent with prior literature. However, we identified some interesting nuances that are of clinical importance. The results of this study may serve as a starting point for future research.

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Section: Discussionmentioning

confidence: 99%

Perceptions and experiences of fertility preservation in Greek female cancer patients

Taniskidou

Voultsos

Tarlatzis

et al. 2023

Preprint

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“…Breast cancer is considered to be the most prevalent cancer type in female patients, and the main risk factors are due to genetic, lifestyle or environmental influences (65). EDCs are considered to contribute to the increasing incidence of breast cancer, particularly in critical periods of breast development, when mammary gland cells are the most predisposed to atypical differentiation (66)(67)(68).…”

Section: Bpa: a Key Element In Female Cancersmentioning

confidence: 99%

Carcinogenic effects of bisphenol A in breast and ovarian cancers (Review)

et al. 2020

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Endocrine-disrupting chemicals (EDCs) are exogenous chemical compounds ubiquitously found in everyday life of the modern world. EDCs enter the human body where they act similarly to endogenous hormones, altering the functions of the endocrine system and causing adverse effects on human health. Bisphenol A (BPA), the principal representative of this class, is a carbon-based synthetic plastic, and a key element in manufacturing cans, reusable water bottles and medical equipment. BPA mimics the actions of estrogen on multiple levels by activating estrogen receptors α and β. BPA regulates various processes, such as cell proliferation, migration and apoptosis, leading to neoplastic changes. Considering genetic mechanisms, BPA exerts its functions via multiple oncogenic signaling pathways, including the STAT3, PI3K/AKT and MAPK pathways. Furthermore, BPA is associated with various modifications of the reproductive system in both males and females. These alterations include benign lesions, such as endometrial hyperplasia, the development of ovarian cysts, an increase in the ductal density of mammary gland cells and other preneoplastic lesions. These benign lesions may continue to develop to breast or ovarian cancer; the effects of BPA depend on various molecular and epigenetic mechanisms that dictate whether the endocrine or reproductive system is impacted, wherein preexisting benign lesions can become cancerous. The present review supports the need for continuous research on BPA, considering its widespread use and most available data suggesting a carcinogenic effect of BPA on the female reproductive system. Although most studies on BPA have been conducted in vitro with human cells or in vivo with animal models, it can be argued that more studies should be conducted in vivo with humans to further promote understanding of the impact of BPA. Contents 1. Introduction 2. BPA: Everyday exposure 3. Key roles of BPA in the pathogenesis of multiple disorders 4. BPA: A key element in female cancers 5. Conclusions

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“…Furthermore, as in other types of cancer, in individuals exposed to BPA, prostate cancer cells have been related to histone post-transitional modifications, chromatin remodeling, or tumor-suppressor genes with actions in multiple pathways including cell cycle control, invasion, hormonal response or DNA damage repair [36]. The presence of the androgen receptor characterizes more than 70% of all primary breast cancer tissues [37]. This is connected to a favorable prognosis for low pathological grading, small tumor volume, and prolonged patient survival time [38].…”

Section: Bisphenol-a Effects On Human Health 21 Bpa: Androgen and Estrogen Receptor Pathway Disruptormentioning

confidence: 99%

Ether-Based Polyurethane Foam for Vacuum-Assisted Closure (V.A.C.) of Complicated Postoperative Abdominal Wound Dehiscence

Petca¹,

Negoiță²,

Petca³

et al. 2019

Mater. Plast.

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Background. The macroporous polyurethane ether foam was introduced in the medical field, as early as the 90 ties, for the Vacuum-assisted closure (V.A.C.) of a wound. We describe our experience after treating abdominal wound dehiscence in a group of elderly gynecological patients with NPWT (Negative Pressure Wound Therapy), using ether foam coated with a silver layer. We reviewed elderly patients chart data that underwent abdominal surgery complicated with wound dehiscence treated with VAC for eighteen months. In all patients, the system used was the standard GranuFoam Silver dressing (different extents), which was usually replaced every 48/72 h. A total of 15 consecutive female patients were included. The median age was 67.3 (58-71) years. Duration of VAC treatment was median 14.2 (11-34) days, and we saw an improvement in wound repair but also clearance of S.S.I. on the third day after applying V.A.C. Ulta. Definitive secondary closure of the wound was obtained in all patients, as the infection�s site clearance. The abdominal VAC treatment with GranuFoam Silver dressing in patients with infected abdominal wound dehiscence is safe and has proper patient compliance. The latest evolution of the silver foam polyether dressing, in conjunction with NPWT therapy, offers a better antimicrobial effect and shorter healing stage.

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State of the Art in Fertility Preservation for Female Patients Prior to Oncologic Therapies

Cited by 5 publications

References 82 publications

Perceptions and experiences of fertility preservation in Greek female cancer patients

Perceptions and experiences of fertility preservation in Greek female cancer patients

Carcinogenic effects of bisphenol A in breast and ovarian cancers (Review)

Ether-Based Polyurethane Foam for Vacuum-Assisted Closure (V.A.C.) of Complicated Postoperative Abdominal Wound Dehiscence

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