State-of-the-art: MXene structures in nano-oncology

Manisekaran, Ravichandran; Chettiar, Aruna-Devi Rasu; Kandasamy, Ganeshlenin; Garcia-Contreras, Rene; Acosta-Torres, Laura Susana

doi:10.1016/j.bioadv.2023.213354

Cited by 8 publications

(6 citation statements)

References 140 publications

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“…In another study by Franke et al, (33) administering Cis through nanoparticles resulted in a significant induction in DNA damage at low doses (0.015 mg/ml), which is in contrast to our findings that showed a cytotoxic effect at a concentration greater than 0.03 mg/ml, highlighting the importance of understanding the nuances of different nanoparticle-drug formulations in achieving the desired therapeutic outcomes. Manisekaran et al (34) conducted a comprehensive review of the literature on the use of MXene nanoparticles as antineoplastic agents in a 2D model. MXenes are a new class of 2D materials that have shown promise in various biomedical applications due to their unique physicochemical properties, including their high surface area, excellent biocompatibility, and tunable surface chemistry.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Antineoplastic Nanocarriers on 3D Oral Cancer Spheroids

MENDOZA-MARTINEZ,

CADENA-GALEANA,

VILLANUEVA-SANCHEZ

et al. 2023

In Vivo

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Background/Aim: Cancer is a leading cause of death worldwide. Conventional treatments as surgery, chemotherapy, radiotherapy, and combined therapies are commonly used. However, these therapies have several limitations and side effects. To address these issues, innovative research is being conducted on nanocarriers (NCs) functionalized with antineoplastic agents. These NCs aim to overcome limitations and improve patients' lives. However, before they can be used clinically, these NCs are primarily assessed on a lab scale to determine their efficacy. Materials and Methods: A primary cell culture was established from a lymphoblastic neoplasm in the maxilla. After characterization, the cells were cultured in 2D to evaluate the dose-effect of nanoparticles (NPs), such as Zinc oxide (ZnO) and Magnesium oxide (MgO), as well as those of free drugs of 5-fluorouracil (5-FU) and cisplatin (Cis). Based on the results, a 3D spheroid culture was used for further study. Finally, the spheroids were histologically processed for immuno-morphological observation. Results: To evaluate spheroid cell viability, we conducted an MTT assay. Treatment of cell spheroids with ZnONPs, 5-FU, and NPs conjugated with antitumor agents such as 5-FU-ZnO and Cis-ZnO decreased cell viability by >25%, >60% and >10% and <20% at a concentration of 0.06, 0.015 and 0.015 & 0.03 mg/ml, respectively. Conclusion: Nanoparticles conjugated with antitumor agents showed promising antineoplastic effects on both 2D and 3D cell cultures. However, the efficacy of the nanoparticles varied between the different models. This highlights the importance of selecting appropriate in vitro culture models for the evaluation of biomedical agents.Cancer remains a significant public health problem and is one of the leading causes of mortality and morbidity worldwide. In the United States, it is estimated that there will be an increase of 1,958,310 new cases and 609,820 cancer deaths by 2023 (1). Hematological neoplasms are the third most common type of cancer after lung and breast neoplasms. In Mexico, cancer is the ninth leading cause of death, with lymphomas, leukemias, and myelomas being the most frequent types, accounting for 10% of all cancer diagnoses (2-5).In recent years, cancer nanotechnology has become increasingly important for the diagnosis and treatment of cancer, with the goal of improving human well-being. The field has seen substantial development, with the approval of over 50 nano-based drugs by the US Food and Drug Administration (FDA). These drugs have shown promise in improving the effectiveness of cancer treatment while minimizing side effects (6-8). Malignant neoplasms of the head and neck are traditionally treated with a combination of surgery, radiation therapy, or both, depending on the size, type, and location (9-11). In recent years, nanoparticles (NPs) have received increasing attention due to their unique and promising characteristics. Among the different types of nanoparticles, nanocarriers (NCs) have shown potential in 1658

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Section: Discussionmentioning

confidence: 99%

Efficacy of Antineoplastic Nanocarriers on 3D Oral Cancer Spheroids

MENDOZA-MARTINEZ,

CADENA-GALEANA,

VILLANUEVA-SANCHEZ

et al. 2023

In Vivo

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“…100 Kalambate et al reviewed the progress of electrochemical (bio) sensors for the detection of biomarkers, pharmaceutical drugs, and environmental contaminants, including how the synthetic strategies and surface functionalization affect various properties of MXenes. 101 Many other excellent recent reviews of MXene-based sensors are also available, [102][103][104][105][106][107][108][109][110][111] and this work provides updates through 2023.…”

Section: The Applications Of Mxenes In Electrochemical (Bio)sensorsmentioning

confidence: 99%

Recent advances using MXenes in biomedical applications

Lee,

Li,

Thomas

et al. 2024

Mater. Horiz.

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“…[135] This treatment method can improve the success rate of treatment, reduce the toxic and side effects of drugs, and also cut down the treatment time. [136] Fu et al [137] constructed a multifunctional 2D nanoplatform BP/Pd-FPEI-CpG based on BP/palladium. The BP/Pd-FPEI-CpG nanoplatform combined three tumor treatment modes of photothermal (PTT)/photodynamic (PDT)/chemodynamic (CDT), and the results showed that the multimodal tumor combination therapy of BP/Pd-FPEI-CpG nanoplatform had a notable improvement in the effect of tumor treatment.…”

Section: Synergistic Therapymentioning

confidence: 99%

“…[ 135 ] This treatment method can improve the success rate of treatment, reduce the toxic and side effects of drugs, and also cut down the treatment time. [ 136 ] Fu et al. [ 137 ] constructed a multifunctional 2D nanoplatform BP/Pd‐FPEI‐CpG based on BP/palladium.…”

Section: Synergistic Therapymentioning

confidence: 99%

Post‐Graphene 2D Materials: Structures, Properties, and Cancer Therapy Applications

Kuang,

Hui,

Chen

et al. 2023

Adv Healthcare Materials

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Cancer is one of the most serious diseases challenging human health and life span. Cancer has claimed millions of lives worldwide. Early diagnosis and effective treatment of cancer are very important for the survival of patients. In recent years, two‐dimensional (2D) nanomaterials have shown great potential in development of anticancer treatment by combining their inherent physicochemical properties after surface modification. 2D nanomaterials have attracted great interest due to their unique nanosheet structure, large surface area, and extraordinary physicochemical properties. This article reviews the advantages and application status of emerging 2D nanomaterials for targeted tumor synergistic therapy comparing with traditional therapeutic strategies. In order to investigate novel potential anticancer strategies, this paper focuses on the surface modification, cargo delivery capability and unique optical properties of emerging 2D nanomaterials. Finally, the current problems and challenges in cancer treatment are summarized and prospected.This article is protected by copyright. All rights reserved

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State-of-the-art: MXene structures in nano-oncology

Cited by 8 publications

References 140 publications

Efficacy of Antineoplastic Nanocarriers on 3D Oral Cancer Spheroids

Efficacy of Antineoplastic Nanocarriers on 3D Oral Cancer Spheroids

Recent advances using MXenes in biomedical applications

Post‐Graphene 2D Materials: Structures, Properties, and Cancer Therapy Applications

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