State of the art of intraocular lens manufacturing

Yu, Nan; Wu, Bing; Zeng, Lan; Cheng, Ying

doi:10.1007/s00170-018-2274-5

Cited by 26 publications

(23 citation statements)

References 135 publications

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“…This suggests that the use of a similar technique could be employed on a pre-hydrated CL material. The usage of such precision manufacturing techniques to intraocular lens manufacturing was also reported [232]. All of these techniques are subject to the effect which the resulting material will have on the ocular environment, such as the effect on the tear film, protein deposition, optical properties, etc.…”

Section: Manufacturing Perspectivesmentioning

confidence: 99%

Contact Lens Materials: A Materials Science Perspective

2019

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More is demanded from ophthalmic treatments using contact lenses, which are currently used by over 125 million people around the world. Improving the material of contact lenses (CLs) is a now rapidly evolving discipline. These materials are developing alongside the advances made in related biomaterials for applications such as drug delivery. Contact lens materials are typically based on polymer- or silicone-hydrogel, with additional manufacturing technologies employed to produce the final lens. These processes are simply not enough to meet the increasing demands from CLs and the ever-increasing number of contact lens (CL) users. This review provides an advanced perspective on contact lens materials, with an emphasis on materials science employed in developing new CLs. The future trends for CL materials are to graft, incapsulate, or modify the classic CL material structure to provide new or improved functionality. In this paper, we discuss some of the fundamental material properties, present an outlook from related emerging biomaterials, and provide viewpoints of precision manufacturing in CL development.

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Section: Manufacturing Perspectivesmentioning

confidence: 99%

Contact Lens Materials: A Materials Science Perspective

2019

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“…PMMA IOLs were the first implantable material used in the early generation of IOL technology by Ridley [64]. The biostability, low inflammatory response, compatibility with injection moulding protocols, and refractive index of 1.49 made PMMA the preferred material over glass [63,65,66]. Nevertheless, the rigidity, intolerance to elevated pressure levels, lower biocompatibility relative to silicone and acrylic, and brittleness of PMMA has led to the replacement of PMMA with more flexible materials.…”

Section: Lens Materialsmentioning

confidence: 99%

Factors Affecting Posterior Capsule Opacification in the Development of Intraocular Lens Materials

Cooksley

Lacey²,

Dymond

et al. 2021

Pharmaceutics

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Posterior capsule opacification (PCO) is the most common complication arising from the corrective surgery used to treat cataract patients. PCO arises when lens epithelial cells (LEC) residing in the capsular bag post-surgery undergo hyper-proliferation and transdifferentiation into myofibroblasts, migrating from the posterior capsule over the visual axis of the newly implanted intraocular lens (IOL). The developmental pathways underlying PCO are yet to be fully understood and the current literature is contradictory regarding the impact of the recognised risk factors of PCO. The aim of this review is firstly to collate the known biochemical pathways that lead to PCO development, providing an up-to-date chronological overview from surgery to established PCO formation. Secondly, the risk factors of PCO are evaluated, focussing on the impact of IOLs’ properties. Finally, the latest experimental model designs used in PCO research are discussed to demonstrate the ongoing development of clinical PCO models, the efficacy of newly developed IOL technology, and potential therapeutic interventions. This review will contribute to current PCO literature by presenting an updated overview of the known developmental pathways of PCO, an evaluation of the impact of the risk factors underlying its development, and the latest experimental models used to investigate PCO. Furthermore, the review should provide developmental routes for research into the investigation of potential therapeutic interventions and improvements in IOL design in the aid of preventing PCO for new and existing patients.

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“…The incidence rate of PCO can be lowered through an appropriate design of the implanted IOLs. Several studies focused on the influence of the lens material [ 155 ], edge squareness, and surface modifications [ 156 , 157 ] in order to inhibit cell adhesion and proliferation on the device. Square edges, in particular, inhibit the migration of epithelial cells to the optic part of the IOL, thus preventing the pathology [ 158 ].…”

Section: Lenses For Ocular Diseasesmentioning

confidence: 99%

Therapeutic Ophthalmic Lenses: A Review

2020

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An increasing incidence of eye diseases has been registered in the last decades in developed countries due to the ageing of population, changes in lifestyle, environmental factors, and the presence of concomitant medical conditions. The increase of public awareness on ocular conditions leads to an early diagnosis and treatment, as well as an increased demand for more effective and minimally invasive solutions for the treatment of both the anterior and posterior segments of the eye. Despite being the most common route of ophthalmic drug administration, eye drops are associated with compliance issues, drug wastage by lacrimation, and low bioavailability due to the ocular barriers. In order to overcome these problems, the design of drug-eluting ophthalmic lenses constitutes a non-invasive and patient-friendly approach for the sustained drug delivery to the eye. Several examples of therapeutic contact lenses and intraocular lenses have been developed, by means of different strategies of drug loading, leading to promising results. This review aims to report the recent advances in the development of therapeutic ophthalmic lenses for the treatment and/or prophylaxis of eye pathologies (i.e., glaucoma, cataract, corneal diseases, or posterior segment diseases) and it gives an overview of the future perspectives and challenges in the field.

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State of the art of intraocular lens manufacturing

Cited by 26 publications

References 135 publications

Contact Lens Materials: A Materials Science Perspective

Contact Lens Materials: A Materials Science Perspective

Factors Affecting Posterior Capsule Opacification in the Development of Intraocular Lens Materials

Therapeutic Ophthalmic Lenses: A Review

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