State of the Art Pharmacological Therapy for Atrial Fibrillation

Канорский, С. Г.; Коваленко, Ю. С.

doi:10.15829/1560-4071-2017-7-171-177

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…У лиц старше 40 лет риск развития ФП составляет 25% [3]. Несмотря на активно внедряющиеся в медицинскую практику хирургические методы лечения аритмий, медикаментозное лечение остается на первом месте [4][5][6]. В связи с этим продолжается разработка неинвазивных методик, повышающих точность клинической диагностики и эффективность подбора лечебных схем.…”

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Analysis of the Results of Five Year Patients Follow-Up in Paroxysmal Atrial Fibrillation Treated With Antiarrhythmics

Rybakova¹,

Столярова²,

Назаркина³

et al. 2018

Russ J Cardiol

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Aim.To analyze the results of 5-year follow-up of the paroxysmal atrial fibrillation patients (PAF) taking antiarrhythmic therapy (AAT)Material and methods.Patients (n=500) were selected to 11 groups: I — healthy, II — controls, III-XI — PAF taking AAT. The baseline parameters of heart rate variability (HRV) were assessed during 5-year follow-up.Results.Decrease of SDNN does 1,9 times increase the risk of AF development during the first 3 months from preventive AAT start. Decrease of RMSSD does 3,9 times increase the risk of AF during the first 2 weeks, and 1,9 times — 3 months; decrease of Delta X increases the risk of AF 3,9 times during 2 weeks, 2 times — during 3 months, 1,4 times — during 6 months, 1,3 times — during 12 months and 3 years. Increase of Amo does 1,8 times increase the risk of AF during first 3 months. If there was baseline decrease of Delta X and RMSSD, then within 2 weeks the AF paroxysm developed in 7,9% patients, and in 3 months — 15,9% patients. With the decrease of Delta X and RMSSD, in combination with low SDNN, the probability of sinus rhythm retention during 1 year is 51,2%.Conclusion.PAF patients taking preventive AAT demand for ECG assessment of HRV parameters no less than once per 3 months.

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Analysis of the Results of Five Year Patients Follow-Up in Paroxysmal Atrial Fibrillation Treated With Antiarrhythmics

Rybakova¹,

Столярова²,

Назаркина³

et al. 2018

Russ J Cardiol

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Pharmacokinetics Study of the Long-acting Antiarrhythmic Drug of Lappaconitine Hydrobromide (Allaforte®, JSC "Pharmcenter VILAR", Russia)

Archakova

Bagaeva

Komarov

et al. 2022

Razrabotka i registraciâ lekarstvennyh sredstv

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Introduction. Allaforte® (JSC "Pharmcenter VILAR", Russia) is an antiarrhythmic long-acting drug. The dosage form of the drug Allaforte® provides a decrease in the frequency of taking the drug and also reduces the risk of side effects. It is relevant when taking antiarrhythmic drugs of the IC class. However, the pharmacokinetics of this drug has not been studied on humans. Therefore, it is important to fully study the pharmacokinetics to ensure the maximum efficacy and safety of arrhythmia therapy.Aim. The aim is pharmacokinetics study of long-acting antiarrhythmic drug Allaforte® (JSC "Pharmcenter VILAR", Russia), 25 mg. Materials and methods. Concentration of lappaconitine and its active metabolite N-desacetyllappaconitine in human plasma determinates by high performance liquid chromatography with tandem mass-spectrometry. Pharmacokinetic parameters calculated by R Project 3.5.1 software (package «bear», version 2.8.3-2), originally created by Hsin-ya Lee and Yung-jin Lee, Taiwan.Results and discussion. Pharmacokinetic parameters of lappaconitine and N-desacetyllappaconitine were calculated. Averaged pharmacokinetic profiles (in linear and semi-log scale) of lappaconitine and N-desacetyllappaconitine after single administration under fasting were built. The means of the maximum concentrations (Cmax) determined in the blood plasma of volunteers after single administration Allaforte® are 5.09 ± 4.07 ng/ml for lappaconitine and 11.66 ± 6.21 ng/ml for N-deacetyllappaconitine (Mean ± SD). The peak time of the maximum concentrations (Tmax) is 4.43 ± 3.54 hours for lappaconitine and 4.04 ± 2.18 hours for N-deacetyllappaconitine. The means of the areas under the curve plasma concentration – time from 0 to 48 hours (AUC0-t) and under the curve plasma concentration–time from zero to infinity (AUC0-∞) of Allaforte® is 42.96 ± 34.48 ng ∙ h/ml and 71.24 ± 43.20 ng ∙ h/ml for lappaconitine; 167.42 ± 114.41 ng ∙ h/ml and 189.42 ± 115.20 ng ∙ h/ml for N-deacetyllappaconitine. Allaforte® was eliminated from blood plasma with means of terminal half-life (T1/2) 8.45 ± 5.10 hours for lappaconitine and 9.04 ± 2.57 hours for N-deacetyllappaconitine.Conclusion. Pharmacokinetics study of long-acting antiarrhythmic drug Allaforte® (JSC "Pharmcenter VILAR", Russia) after single administration was researched. Results of the study allows to conduct an effective therapy of arrhythmia by study drug and minimize side effects.

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State of the Art Pharmacological Therapy for Atrial Fibrillation

Cited by 2 publications

References 38 publications

Analysis of the Results of Five Year Patients Follow-Up in Paroxysmal Atrial Fibrillation Treated With Antiarrhythmics

Analysis of the Results of Five Year Patients Follow-Up in Paroxysmal Atrial Fibrillation Treated With Antiarrhythmics

Pharmacokinetics Study of the Long-acting Antiarrhythmic Drug of Lappaconitine Hydrobromide (Allaforte®, JSC "Pharmcenter VILAR", Russia)

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