State-of-the-art review of advanced electrospun nanofiber yarn-based textiles for biomedical applications

Wu, Shaohua; Dong, Ting; Li, Yiran; Sun, Mingchao; Qi, Ye; Liu, Jiao; Kuss, Mitchell; Chen, Shaojuan; Duan, Bin

doi:10.1016/j.apmt.2022.101473

Cited by 112 publications

(113 citation statements)

References 232 publications

(241 reference statements)

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“…Porous nanofiber prepared by electrospinning have the advantages of high specific surface area, high porosity, and high adsorption [ 27 ]. It is widely used in filtration, sensors, and adsorption [ 28 , 29 ]. A variety of polymers such as polycaprolactone, polystyrene, and PLA can be obtained by electrostatic spinning [ 30 , 31 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Biodegradable Poly(L-lactic acid) Nanofiber Membranes as Highly Porous Oil Sorbent Nanomaterials

Yang

Lu³

et al. 2022

Nanomaterials

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Crude oil spills seriously harm the ocean environment and endanger the health of various animals and plants. In the present study, a totally biodegradable polymer, poly(L-lactic acid) (PLLA), was employed to fabricate highly porous oil absorbent nanofibrous materials by using a combination of electrospinning technique and subsequent acetone treatment. We systematically investigated how the electrospinning parameters affected formation of the porous structure of PLLA nanofibers and demonstrated that PLLA nanofibers with decreased and uniform diameter and improved porosity could be rapidly prepared by adjusting solution parameters and spinning parameters. We also demonstrated that the acetone treatment could obviously enhance the pore diameter and specific surface area of as-optimized electrospun PLLA nanofibers. The acetone treatment could also improve the hydrophobic property of as-treated PLLA nanofiber membranes. All these led to a significant increase in oil absorption performance. Through our research, it was found that the oil absorption of PLLA nanofiber membrane increased by more than double after being treated with acetone and the oil retention rate was also improved slightly.

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Section: Introductionmentioning

confidence: 99%

Electrospun Biodegradable Poly(L-lactic acid) Nanofiber Membranes as Highly Porous Oil Sorbent Nanomaterials

Yang

Lu³

et al. 2022

Nanomaterials

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“…Regarding materials used for electrospinning, various polymers can be selected according to specific requirements of impaired skin. For example, the poly (lactic-co-glycolic acid), polycaprolactone and silk fibroin as scaffolds provide favorable mechanical properties, and materials like hyaluronic acid, chitosan and polyethylene oxide are polymers with antibacterial effects ( Wang et al, 2020a ; Ionescu et al, 2021 ; Luo et al, 2021 ; Sun et al, 2021 ; Wu et al, 2022 ; Zamboni et al, 2023 ). Besides, the alginate, poly (vinyl alcohol) and gelatin as absorbent polymers are selected to remove wound exudates and keep the wound moist ( Yang et al, 2021 ; Yang et al, 2022 ).…”

Section: Electrospinning Of Botanicals For Skin Wound Healingmentioning

confidence: 99%

Electrospinning of botanicals for skin wound healing

Guo

Wang

Song

et al. 2022

Front. Bioeng. Biotechnol.

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Being the first barrier between the human body and external environments, our skin is highly vulnerable to injuries. As one of the conventional therapies, botanicals prepared in different topical formulations have been applied as medical care for centuries. With the current increase of clinical requirements, applications of botanicals are heading towards nanotechnologies, typically fused with electrospinning that forms nanofibrous membranes suitable for skin wound healing. In this review, we first introduced the main process of wound healing, and then presented botanicals integrated into electrospun matrices as either loaded drugs, or carriers, or membrane coatings. In addition, by addressing functional features of individual botanicals in the healing of injured skin, we further discussed the bioactivity of botanical electrospun membranes in relevant to the medical issues solved in the process of wound healing. As achieved by pioneer studies, due to infrequent adverse effects and the diversity in resources of natural plants, the development of electrospun products based on botanicals is gaining greater attention. However, investigations in this field have mainly focused on different methodologies used in the preparation of nanofibrous membranes containing botanicals, their translation into clinical practices remains unaddressed. Accordingly, we propose that potential clinical applications of botanical electrospun membranes require not only the further expansion and understanding of botanicals, but also an establishment of standard criteria for the evaluation of wound healing and evolutions of technologies to support the large-scale manufacturing industry.

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“…As the control, the diameters of fibers generated from electrospinning are located in the same rang with the native collagen fibrils in skin tissues [ 13 ]. Many existing studies have demonstrated that the electrospinning nanofibers could promote cell attachment, the proliferation of human dermal fibroblasts in vitro, and the acceleration of wound healing and skin regeneration in vivo [ 14 ]. Importantly, electrospinning-based nanofibers are always collected into nonwoven mat-like structure, which has been demonstrated to possess great air and moisture permeability, as well as excellent pathogen barrier properties [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Chitosan–Polyvinyl Alcohol Nanofiber Dressings Loaded with Bioactive Ursolic Acid Promoting Diabetic Wound Healing

Zhao

et al. 2022

Nanomaterials

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The design and development of novel dressing materials are urgently required for the treatment of chronic wounds caused by diabetic ulcers in clinics. In this study, ursolic acid (UA) extracted from Chinese herbal plants was encapsulated into electrospun nanofibers made from a blend of chitosan (CS) and polyvinyl alcohol (PVA) to generate innovative CS-PVA-UA dressings for diabetic wound treatment. The as-prepared CS-PVA-UA nanofiber mats exhibited randomly aligned fiber morphology with the mean fiber diameters in the range of 100–200 nm, possessing great morphological resemblance to the collagen fibrils which exist in the native skin extracellular matrix (ECM). In addition, the CS-PVA-UA nanofiber mats were found to possess good surface hydrophilicity and wettability, and sustained UA release behavior. The in vitro biological tests showed that the high concentration of UA could lead to slight cytotoxicity. It was also found that the CS-PVA-UA nanofiber dressings could significantly reduce the M1 phenotypic transition of macrophages that was even stimulated by lipopolysaccharide (LPS) and could effectively restore the M2 polarization of macrophages to shorten the inflammatory period. Moreover, the appropriate introduction of UA into CS-PVA nanofibers decreased the release levels of TNF-α and IL-6 inflammatory factors, and suppressed oxidative stress responses by reducing the generation of reactive oxygen species (ROS) as well. The results from mouse hepatic hemorrhage displayed that CS-PVA-UA nanofiber dressing possessed excellent hemostatic performance. The in vivo animal experiments displayed that the CS-PVA-UA nanofiber dressing could improve the closure rate, and also promote the revascularization and re-epithelization, as well as the deposition and remodeling of collagen matrix and the regeneration of hair follicles for diabetic wounds. Specifically, the mean contraction rate of diabetic wounds using CS-PVA-UA nanofiber dressing could reach 99.8% after 18 days of treatment. In summary, our present study offers a promising nanofibrous dressing candidate with multiple biological functions, including anti-inflammation, antioxidation, pro-angiogenesis, and hemostasis functions, for the treatment of hard-to-heal diabetic wounds.

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State-of-the-art review of advanced electrospun nanofiber yarn-based textiles for biomedical applications

Cited by 112 publications

References 232 publications

Electrospun Biodegradable Poly(L-lactic acid) Nanofiber Membranes as Highly Porous Oil Sorbent Nanomaterials

Electrospun Biodegradable Poly(L-lactic acid) Nanofiber Membranes as Highly Porous Oil Sorbent Nanomaterials

Electrospinning of botanicals for skin wound healing

Electrospun Chitosan–Polyvinyl Alcohol Nanofiber Dressings Loaded with Bioactive Ursolic Acid Promoting Diabetic Wound Healing

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