State‐of‐the‐art staging in prostate cancer

Wilkinson, B.A.; Hamdy, Freddie C.

doi:10.1046/j.1464-410x.2001.02146.x

Cited by 41 publications

(25 citation statements)

References 58 publications

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“…Clinical details recorded included age, stage as described by Wilkinson and Hamdy (2001), tumour grade as defined by Chodak et al (1994), circulating concentrations of PSA and haemoglobin at diagnosis, and subsequent treatment.…”

Section: Patientsmentioning

confidence: 99%

The relationship between T-lymphocyte subset infiltration and survival in patients with prostate cancer

et al. 2004

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The relationship between tumour stage, T-lymphocyte subset infiltration and survival was examined in patients with prostate cancer (n ¼ 80). On multivariate analysis PSA (HR 2.47, 95% CI 1.27 -4.83, P ¼ 0.008) and CD4 þ T-lymphocyte count (HR 2.29, 95% CI 1.25 -4.22, P ¼ 0.008) had independent significance. Increased CD4 þ T-lymphocyte infiltration within the tumour was stage independent and associated with poor outcome in patients with prostate cancer.

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Section: Patientsmentioning

confidence: 99%

The relationship between T-lymphocyte subset infiltration and survival in patients with prostate cancer

et al. 2004

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“…In up to 51% of procedures, this can lead to postoperative complications such as lymphoceles, injuries to the obturator nerve and/or the ureter, and lymphedema of the lower extremity. 2,3 Surgical pelvic lymphadenectomy procedures such as extended pelvic lymphadenectomy [4][5][6] can be improved by relying on better surgical guidance toward the tumor draining lymphatic tract and LN(s). Ideally, an intraoperative imaging approach enables the surgeon to visualize and excise the tumor draining LNs accurately, which may shorten overall procedure time and decrease complication levels.…”

Section: Introductionmentioning

confidence: 99%

Tracer-cocktail injections for combined pre- and intraoperative multimodal imaging of lymph nodes in a spontaneous mouse prostate tumor model

et al. 2011

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Abstract. To improve surgical guidance toward prostate draining lymph nodes, we investigate the potential of intraoperative fluorescence imaging and combined pre-and intraoperative multimodality imaging approaches. Transgenic adenocarcinoma mouse prostate mice with spontaneous prostate tumors are injected intratumorally with: 1. a cocktail of patent blue (Pb) and indocyanine green (ICG); 2. a cocktail of albumin radiocolloids ( 99m TcNanoColl), Pb, and ICG; or 3. a cocktail of radiolabeled albumin ( 99m Tc-Vasculosis), Pb, and ICG. The distribution of these imaging agents over the lymph nodes (LNs) are studied at different time points after injection. We find that at 60-min postinjection, ICG significantly improves the detection of the LNs compared to Pb, 53 versus 7%, respectively. Moreover, a cocktail of ICG and 99m Tc-NanoColl improves the fluorescent detection rate to 86%, equalling that of the clinically applied 99m Tc-NanoColl. A similar overlap is observed in our initial clinical pilot data. Fluorescent detection of the LNs using a ICG with 99m Tc-Vasculosis gives similar results as "free" ICG (58%; 60 min). A 99m Tc-NanoColl, Pb, and cocktail ICG enriches the standard 99m Tc-NanoColl approach by adding optical detection of the sentinel lymph nodes. Furthermore, this approach improves fluorescent-based guidance and enables both accurate surgical planning and intraoperative detection, based on a single injection. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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“…Na década passada, nos Estados Unidos (1994), 50% a 60% dos pacientes com câncer de prós-tata tinham metástases ósseas ao serem diagnosticados (5) . A disseminação dos programas para detecção precoce e a introdução do teste de PSA têm aumentado a taxa de diagnóstico em fases mais iniciais (3,5) .…”

Section: Câncer De Próstataunclassified

“…Foi primeiramente isolado em 1979 (3) . No iní-cio dos anos 90 ganhou popularidade como o marcador tumoral mais importante no manuseio do câncer de próstata.…”

Section: Antígeno Prostático Específicounclassified

“…Um estudo multicêntrico de 4.133 homens mostrou uma relação linear entre os níveis aumentados de PSA e a presença de doença extraprostática: 64% dos que apresentavam níveis < 4 µg/l e somente 9% dos que apresentavam PSA sérico > 50 µg/l tinham doença confinada ao órgão (3) . O advento do PSA sérico e a implementação dos programas de "screening" para detecção precoce do câncer de próstata têm determinado mudanças no estágio patológico em que o diagnóstico é realizado.…”

Section: Antígeno Prostático Específicounclassified

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Cintilografia óssea no câncer de próstata

Abreu

Chaves²,

Soares³

et al. 2005

Radiol Bras

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Este estudo propõe-se a revisar os aspectos de indicação da cintilografia óssea no estadiamento e acompanhamento dos pacientes com câncer de próstata. Os autores fazem um levantamento da literatura e analisam os critérios de indicação do exame, comparando-o com outras modalidades propedêuticas na avaliação desses pacientes. As aplicações da cintilografia óssea no câncer de próstata são estabelecidas segundo os novos parâmetros descritos na literatura, levando em conta, ainda, a relação custo/benefício. Unitermos: Cintilografia óssea; Câncer de próstata.Bone scintigraphy in patients with prostate cancer. The aim of this study is to look over the indications for bone scintigraphy in the staging and follow-up of patients with prostate cancer. The authors reviewed the literature on the subject and analyzed the criteria used for indication of this test, and compared it with other methods for the evaluation of patients with this condition. Clinical applications of bone scintigraphy in prostate cancer are established according to new parameters described in the literature, also taking into consideration its cost-effectiveness.

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State‐of‐the‐art staging in prostate cancer

Cited by 41 publications

References 58 publications

The relationship between T-lymphocyte subset infiltration and survival in patients with prostate cancer

The relationship between T-lymphocyte subset infiltration and survival in patients with prostate cancer

Tracer-cocktail injections for combined pre- and intraoperative multimodal imaging of lymph nodes in a spontaneous mouse prostate tumor model

Cintilografia óssea no câncer de próstata

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