State of the art – sirtuin 1 in kidney pathology – clinical relevance

Bazyluk, Angelika; Małyszko, Jolanta; Hryszko, Tomasz; Zbroch, Edyta

doi:10.1016/j.advms.2019.04.005

Cited by 12 publications

(9 citation statements)

References 126 publications

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“…Several studies have also established that SIRT1 activation significantly attenuates cell apoptosis. 14,18 In agreement, our results…”

Section: Discussionsupporting

confidence: 93%

“…This observation was supported by data showing higher cell apoptosis and renal pathological damage and renal dysfunction, and less cell viability in the EX group than in the PIO group. Several studies have also established that SIRT1 activation significantly attenuates cell apoptosis 14,18 . In agreement, our results indicated that PIO was protective on cisplatin‐treated samples and that this effect was achieved via SIRT1‐dependent suppression of cell apoptosis.…”

Section: Discussionsupporting

confidence: 89%

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Pioglitazone alleviates cisplatin nephrotoxicity by suppressing mitochondria‐mediated apoptosis via SIRT1/p53 signalling

Zhang

Zou

Cheng‐Jing³

et al. 2020

J Cellular Molecular Medi

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“…Several studies have also established that SIRT1 activation significantly attenuates cell apoptosis. 14,18 In agreement, our results…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 89%

Pioglitazone alleviates cisplatin nephrotoxicity by suppressing mitochondria‐mediated apoptosis via SIRT1/p53 signalling

Zhang

Zou

Cheng‐Jing³

et al. 2020

J Cellular Molecular Medi

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“…Additionally, metformin can affect the aging process via deacetylases. Previously, studies have reported that metformin can activate SIRT1 to improve renal outcomes, owing to the SIRT1 involvement in the pathogenesis of age-dependent and metabolic diseases [126]. Similarly, in cardiomyocytes, SIRT2 promotes AMPK activation by deacetylating kinase LKB1.…”

Section: Mechanisms Underlying the Anti-ageing Effect Of Metforminmentioning

confidence: 99%

Metformin: A Potential Candidate for Targeting Aging Mechanisms

Hu¹,

Xie²,

Xiao³

et al. 2021

Aging and disease

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Aging is a universal phenomenon in all biological organisms, defined by the loss of reproductive capacity and a progressive decline in fitness. In humans, aging is further associated with an increased incidence of disease conditions. The current aging population has become a primary public burden of the 21 st century. Therefore, to delay the aging process and maintain fitness in the aging population, the discovery of novel antiaging drugs remains an urgent need. In recent years, metformin, a widely used hypoglycemic drug, has attracted growing attention in the field of anti-aging research. Reportedly, numerous studies have indicated that metformin regulates aging-related pathways, possibly delaying the aging process by modulating these pathways. The elucidation of these anti-aging effects may provide insights into the age-retarding potential of metformin. The present review focuses on the predominant molecular mechanisms associated with aging, as well as the anti-aging effects of metformin.

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“…One of the molecules suggested as a target in the treatment of many diseases is the silent information regulator (SIRT1), a member of nicotinamide adenine dinucleotide-dependent histone deacetylase‎ that regulates various biological pathways by switching off the chromatin and suppressing transcription [ 11 ]. It is in relation to cellular energy metabolism, mitochondrial biogenesis, stress response, apoptosis, inflammation, and fibrosis [ 11 , 12 ]. A collection of evidence suggests that SIRT1 plays a role in protecting cellular stress in kidney disease [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

The effects of two different dietary regimens during exercise on outcome of experimental acute kidney injury

et al. 2022

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Background Acute kidney injury (AKI) is a syndrome characterized by rapid loss of excretory function of kidney. Both exercise and some diets have been shown to increase silent information regulator (SIRT1) expression leading to reduction of kidney injury. In this study, the effect of two different diets during exercise on kidney function, oxidative stress, inflammation and also SIRT1 in AKI was investigated. Materials and methods A number of rats were randomly divided into four groups; control without exercise, control with exercise, exercise + calorie restriction (CR), and exercise + time restriction (TR). Each group was divided into two subgroups of without AKI and with AKI (six rats in each group). Endurance exercise and diets were implemented before AKI. Serum urea and creatinine, urinary albumin, kidney malondialdehyde (MDA), total antioxidant capacity (TAC), transforming growth factor (TGF-β1), and SIRT1 levels, glomerular filtration rate (GFR) and relative kidney weight were measured before and 24 h after AKI induction. Results After induction of kidney injury, serum urea and creatinine, urinary albumin, kidney MDA and TGF-β1 levels increased in rats with both previous exercise and no previous exercise, while GFR, and kidney TAC and SIRT1 levels significantly decreased. These changes after AKI were less in the group with previous exercise than in the group that had no exercise (p <0.001). The TR diet during exercise caused a less increase in serum urea (p <0.01) and creatinine (p <0.01), and urinary albumin (p <0.001) levels after the injury compared to the just exercise group. Also, both CR and TR diets during exercise caused less change in MDA (p <0.001) and TAC (p <0.05, p <0.001, respectively) levels compared to just exercise group. Conclusions The results showed that exercise alone had no effect on preventing function impairment of kidney, oxidative stress, inflammation and also SIRT1 alteration following AKI, although these indexes were less among those with exercise than those without exercise. However, when the CR and TR diets were implemented during exercise, strong renoprotective effects appeared, and the protective effect of TR diet was greater.

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State of the art – sirtuin 1 in kidney pathology – clinical relevance

Cited by 12 publications

References 126 publications

Pioglitazone alleviates cisplatin nephrotoxicity by suppressing mitochondria‐mediated apoptosis via SIRT1/p53 signalling

Pioglitazone alleviates cisplatin nephrotoxicity by suppressing mitochondria‐mediated apoptosis via SIRT1/p53 signalling

Metformin: A Potential Candidate for Targeting Aging Mechanisms

The effects of two different dietary regimens during exercise on outcome of experimental acute kidney injury

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